Results 221 to 230 of about 4,103,638 (290)

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Sequencing asymmetry: the case for caution before first-line pirtobrutinib in chronic lymphocytic leukemia. [PDF]

Ann Hematol
Chen B, Qian S.
europepmc   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Time-Resolved Network Entropy Analysis Identifies a CTNND1-VAV3 Subnetwork in Gefitinib-Resistant NSCLC. [PDF]

Int J Mol Sci
Tsakona DC, Papanikolaou NA.
europepmc   +1 more source

Iterative Selection of DNA Nanostructures for Cellular Uptake

Advanced Materials, EarlyView.
DNA nanostructures are promising cell targeting delivery vehicles for therapeutics, but the targeting behavior is not fully understood. In this study, libraries of DNA nanostructures that can be amplified and sequenced are combined with cellular uptake as a selection pressure to iteratively refine DNA structures taken up in cells to better understand ...
Anjali Rajwar, Lisa Eichhorn, Jakub Palacka, Sandra Ly, Erik Benson   +4 more
wiley   +1 more source

Mechanisms of Resistance to MEK Inhibitors (RAS-MAPK Pathway) in Malignant Peripheral Nerve Sheath Tumors and Their Precursor Lesions (Plexiform Neurofibromas) Associated with Neurofibromatosis Type 1. [PDF]

Cancers (Basel)
Sologov SI, Sologova D, Dubinin D, Anikin G, Bekhorashvili N, Rayisyan M, Krylova E, Yarkova M, Grigorevskikh EM, Smolyarchuk E, Sologova S.   +10 more
europepmc   +1 more source

Synchronized Ablation of Multifocal Tumors Enabled by Multi‐Channel Lanthanide Nanocomposites

Advanced Materials, EarlyView.
A multi‐channel lanthanide nanocomposite enables orthogonal monitoring of tumor pH, glutathione, and temperature to guide customized therapy. Real‐time luminescence readouts determine a single irradiation protocol that synchronizes drug release and photothermal treatment, allowing efficient ablation of multifocal tumors while minimizing overtreatment ...
Fang Li, Zheng Wei, Francesco G. Mutti, Hong Zhang, Felix F. Loeffler, Yuxin Liu, Xingjun Zhu   +6 more
wiley   +1 more source

Exosome-delivered pepDCBLD2 promotes glucose metabolism to induce chemoresistance in colon cancer. [PDF]

J Transl Med
Wang X, Yang J, Yang H, Xu Y, Wang H, Sun M, Gao M, Wang Y, Zhang H.   +8 more
europepmc   +1 more source

Advances in Halide Perovskites for Photon Radiation Detectors

Advanced Materials Technologies, EarlyView.
This work highlights recent progress in perovskite‐based photon radiation detectors, covering organic–inorganic hybrid, inorganic, lead‐free double, and vacancy‐ordered halide perovskites. Their detection performance is compared, material‐specific advantages and challenges are examined, and provides insight into current limitations and future ...
Liangling Wang, Jieqi Wang, Xiaojun Cui, Carsten Ronning   +3 more
wiley   +1 more source

HIF1A⁺CSF3R⁺ neutrophils-dominated hypoxic niche induced metabolic reprogramming for neoadjuvant therapy resistance in NSCLC. [PDF]

J Immunother Cancer
Zhou Y, Liu Z, Kaysar P, Han Y, Ma Y, Yu X, Ni B, Chen Z, Xie Y, Zhang H, Li Y.   +10 more
europepmc   +1 more source