Results 71 to 80 of about 464,133 (328)

Patterns of Ruxolitinib Therapy Failure and Its Management in Myelofibrosis: Perspectives of the Canadian Myeloproliferative Neoplasm Group

JCO Oncology Practice, 2020
Ruxolitinib improves splenomegaly and other disease-related symptoms in patients with myelofibrosis, but over time, many patients lose this benefit. It is difficult to determine whether this is due to resistance or intolerance to the drug; thus, we have ...
Vikas Gupta, Sonia Cerquozzi, L. Foltz, C. Hillis, Rebecca Devlin, M. Elsawy, Kuljit Grewal, C. Hamm, C. McNamara, S. Sirhan, B. Leber   +10 more
semanticscholar   +1 more source

Adult T‐cell leukemia‐lymphoma acquires resistance to DNA demethylating agents through dysregulation of enzymes involved in pyrimidine metabolism

International Journal of Cancer, 2021
Adult T‐cell leukemia‐lymphoma (ATL) is an aggressive neoplasm derived from T‐cells transformed by human T‐cell lymphotropic virus‐1 (HTLV‐1). Recently, we reported that regional DNA hypermethylation in HTLV‐1‐infected T‐cells reflects the disease status
N. Yoshida-Sakai, Tatsuro Watanabe, Yuta Yamamoto, H. Ureshino, K. Kamachi, Y. Kurahashi, Y. Fukuda-Kurahashi, S. Kimura   +7 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Is porto sinusoidal vascular disease to be actively searched in patients with portal vein thrombosis? [PDF]

, 2019
Porto sinusoidal vascular liver disease (PSVD) and portal vein thrombosis (PVT) are distinct vascular liver diseases characterized, respectively, by an intrahepatic and a prehepatic obstacle to the flow in the liver portal system. PVT may also occur as a
D'Amati, G., Gioia, S., Nardelli, S., Ridola, L., Riggio, O.   +4 more
core   +1 more source

Transporter-Mediated Cellular Distribution of Tyrosine Kinase Inhibitors as a Potential Resistance Mechanism in Chronic Myeloid Leukemia

Pharmaceutics, 2023
Chronic myeloid leukemia (CML) is a hematologic neoplasm characterized by the expression of the BCR::ABL1 oncoprotein, a constitutively active tyrosine kinase, resulting in uncontrolled growth and proliferation of cells in the myeloid lineage.
Noor E. Verhagen, Jan B. Koenderink, Nicole M. A. Blijlevens, Jeroen J. W. M. Janssen, Frans G. M. Russel   +4 more
doaj   +1 more source

Drugs Resistance Analysis from Scarce Health Records via Multi-task Graph Representation [PDF]

arXiv, 2023
Clinicians prescribe antibiotics by looking at the patient's health record with an experienced eye. However, the therapy might be rendered futile if the patient has drug resistance. Determining drug resistance requires time-consuming laboratory-level testing while applying clinicians' heuristics in an automated way is difficult due to the categorical ...
arxiv  

Mir-217 Reverses the TKI Drug-Resistance of K562 Cells By the Downregulation of Heme Oxygenase-1

, 2015
Upregulation of Heme oxygenase-1 (HO-1) strengthens drug-resistance to apoptotic death in the several kinds of cancer cells. Our recent study shows the higher levels of HO-1 expression in the thyrosine kinase inhibitors (TKI) resistance K562 cell line ...
Jishi Wang, Chanjuan Wang, D. Ma, Q. Fang, M. Ren   +4 more
semanticscholar   +1 more source

Molecular biomarkers of leukemia: convergence-based drug resistance mechanisms in chronic myeloid leukemia and myeloproliferative neoplasms

Frontiers in Pharmacology
Leukemia represents a diverse group of hematopoietic neoplasms that can be classified into different subtypes based on the molecular aberration in the affected cell population. Identification of these molecular classification is required to identify specific targeted therapeutic approaches for each leukemic subtype.
Meike Kaehler, Nikolas von Bubnoff, Ingolf Cascorbi, Sivahari Prasad Gorantla   +3 more
openaire   +3 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source