Results 81 to 90 of about 278,919 (188)

Research progress on immune checkpoint inhibitors in intrahepatic cholangiocarcinoma

Annals of Medicine
Background Intrahepatic cholangiocarcinoma (ICC) is a relatively uncommon but lethal neoplasm of the biliary tract. Evolving immunotherapy has important implications for the treatment of ICC.
Ziwen Yin, Lin Zhang, Jiexu Li, Haiyang Tan, Bingqi Ma   +4 more
doaj   +1 more source

JAK2 46/1 (GGCC) Haplotype: A Biomarker for Oncogenesis, Risk Stratification, and Drug Resistance in Myeloproliferative Neoplasms

Background: The JAK2 46/1 ("GGCC") haplotype, is an inherited genetic variation within the JAK2 gene locus that has become a focal point in research related to oncogenesis, particularly in myeloproliferative neoplasms (MPNs). Methods: We conducted a narrative review of landmark discoveries in hematological malignancies and JAK2 ...
Michela Perrone, Sara Sergio, Beatrice Pranzo, Amalia Tarantino, Giuseppina Loglisci, Rosella Matera, Davide Seripa, Michele Maffia, Nicola Di Renzo   +8 more
openaire   +1 more source

Non-coding RNA transcripts, incredible modulators of cisplatin chemo-resistance in bladder cancer through operating a broad spectrum of cellular processes and signaling mechanism

Non-coding RNA Research
Bladder cancer (BC) is a highly frequent neoplasm in correlation with significant rate of morbidity, mortality, and cost. The onset of BC is predominantly triggered by environmental and/or occupational exposures to carcinogens, such as tobacco. There are
Mehrdad Hashem, Elaheh Mohandesi Khosroshahi, Melika Aliahmady, Morvarid Ghanei, Yasamin Soofi Rezaie, Yasamin alsadat Jafari, Fatemeh rezaei, Ramtin Khodaparast eskadehi, Kimia Kia Kojoori, faranak jamshidian, Noushin Nabavi, Mohsen Rashidi, Farzaneh Hasani Sadi, Afshin Taheriazam, Maliheh Entezari   +14 more
doaj   +1 more source

Epigenetic dispositions in ovarian clear cell carcinoma: a nexus of genomic, epigenetic, and metabolic alterations

Academia Oncology
Ovarian clear cell carcinoma (CCC) is a highly aggressive malignancy characterized by poor prognosis due to its resistance to chemotherapy, particularly in the advanced stages.
Ken Yamaguchi, Mengxin Jiang, Taito Miyamoto, Rin Mizuno, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Junzo Hamanishi, Yuko Hosoe, Tsukasa Baba, Noriomi Matsumura, Ikuo Konishi, Shingo Fujii, Masaki Mandai   +13 more
doaj   +1 more source

Evaluation of the activity of the immune system and age-related tissue markers in Turquoise killifish \ud (Nothobranchius furzeri, Jubb 1971) \ud and their role in cell ageing\ud [PDF]

, 2010
Currently the Turquoise Killifish is considered the best animal model suitable for aging research. \ud This annual fish, from south east Africa, shows an exceptionally adaptive behaviour to dry periods: indeed, due to this extreme environmental ...
Di Cicco, Emiliano, Rossi, Giacomo
core  

Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma. [PDF]

, 2019
BackgroundPlexiform fibromyxoma (PF) is a rare gastric tumor often confused with gastrointestinal stromal tumor. These so-called "benign" tumors often present with upper GI bleeding and gastric outlet obstruction.
Banerjee, Sudeep, Burgoyne, Adam M, Corless, Christopher L, Davis, Jessica L, Miettinen, Markku M, Noh, Sangkyu, Sicklick, Jason K, Tang, Chih-Min, Ustoy, Rowan, Yebra, Mayra   +9 more
core   +1 more source

Nanoplatform-based theranostics in glioblastoma: A promising frontier for precision oncology

Nano Trends
Glioblastoma (GBM) is the most aggressive primary brain neoplasm, characterized by a poor prognosis and resistance to standard treatments. The tumor's infiltrative characteristics and the tight blood-brain barrier (BBB) impede effective therapy.
Kesavarajan Govindarajan Karthikeyan, Balamurali Venkatesan, Natarajan Vaghesan, Pavithra Selvan, Sakthinarenderan Saikumar   +4 more
doaj   +1 more source

Brain metastasis-associated cancer fibroblasts drive tumor progression and therapeutic resistance through IL26 and CX3CL1 signaling in non-small-cell lung cancer

Experimental Hematology & Oncology
Brain metastases (BM) from non-small cell lung cancer (NSCLC) represent a significant clinical challenge, characterized by poor prognosis and treatment resistance.
S. M. Abdus Salam, Eshrat Jahan, Eun-Jung Ahn, Sung Sun Kim, Yeong Jin Kim, Sue Jee Park, Tae-Young Jung, In-Young Kim, Shin Jung, Roo Ji Lee, Jae-Hyuk Lee, Joon Haeng Rhee, Kyung Keun Kim, Min-Hee Yi, Kyung-Hwa Lee, Kyung-Sub Moon   +15 more
doaj   +1 more source

Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation

Oral Oncology Reports
Oral squamous cell carcinoma (OSCC) is a highly aggressive neoplasm of the surface epithelium that arises from the mucosal lining of the mouth. The poor prognosis can be attributed to the complex tumor microenvironment (TME) in OSCC, which is crucial for
Nitesh Buldak, Vishnu Priya Veeraraghavan, Ullas Mony   +2 more
doaj   +1 more source

Iatrogenic Alterations of Immunologic Surveillance in Man and Their Influence on Malignancy [PDF]

, 1971
Agosin M., Albert D., Alford T. C, Allison A. C, Alpert E., Alpert M. E., Anigsten L., Bach F. H., Baserga R., Bekkum D. W., Berman C., Bortin M. M., Bremberg S., Burnet F. M., Burnet F. M., Burnet F. M., Burnet F. M., Casey T. P., Davis R. C., Dent P. B., Deodhar S. D., Doak P. B., Doll R., Epstein R. B., Fisher E. R., Foley E. J., Foley E. J., Fortner J. G., Grant G. A., Gustafson E. G., Hellman K., Hirsch M. S., Huber J., Immunology and Cancer, Isojima S., Jensen C O., Kay S., Law L. W., MacLean L. D., Mandel M.A., Marchioro T. L., Martin D. C, Martinez C, Mathe G., Mathe G., McIntosh D. A., McKhann C. F., Miller J. F. A. P., Moore G. E., Muizniks H. W., Page A. R., Penn I., Penn I., Penn I., Penn I., Prehn R. T., Pritzker K. P. H., Rabbat A. G., Santos G. W., Santos G. W., Schwartz R., Simmons R. L., Sjogren H. O., Snell G. D., Southam C. M., Speck B., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Tallent M. B., Thomas L., Toolan H.W., Tunner W. S., Tyler A., Vredevoe D. L., Weiler E., Wilson R. E., Zukoski C. F., Zukoski C. F.   +85 more
core   +1 more source