Results 101 to 110 of about 8,375,389 (400)

Antimalarial Drug Resistance and Novel Targets for Antimalarial Drug Discovery

Infection and Drug Resistance, 2020
Malaria is among the most devastating and widespread tropical parasitic diseases in which most prevalent in developing countries. Antimalarial drug resistance is the ability of a parasite strain to survive and/or to multiply despite the administration ...
Melkamu Adigo Shibeshi, Zemene Demelash Kifle, Seyfe Asrade Atnafie   +2 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Potential of nanopore sequencing for tuberculosis diagnosis and drug resistance detection

BMC Infectious Diseases
Objectives This study evaluates the effectiveness of nanopore sequencing for accurate detection of Mycobacterium tuberculosis pathogens and drug resistance mutations in clinical specimens.
Fei Ren, JinBao Ma, LiYun Dang, AiFang Li, GuoLian Zhao, Yun Qi, You Xu, Han Yang, JianYing Li   +8 more
doaj   +1 more source

Using machine learning and big data to explore the drug resistance landscape in HIV.

PLoS Computational Biology, 2021
Drug resistance mutations (DRMs) appear in HIV under treatment pressure. DRMs are commonly transmitted to naive patients. The standard approach to reveal new DRMs is to test for significant frequency differences of mutations between treated and naive ...
Luc Blassel, Anna Tostevin, Christian Julian Villabona-Arenas, Martine Peeters, Stéphane Hué, Olivier Gascuel, UK HIV Drug Resistance Database   +6 more
doaj   +1 more source

Phenotypic Characterization and Heterogeneity among Modern Clinical Isolates of Acinetobacter baumannii

Microbiology Spectrum, 2023
Acinetobacter baumannii is an opportunistic pathogenic bacterium prioritized by WHO and CDC because of its increasing antibiotic resistance. Heterogeneity among strains represents the hallmark of A. baumannii bacteria.
Adam Valcek, Chantal Philippe, Clémence Whiteway, Etienne Robino, Kristina Nesporova, Mona Bové, Tom Coenye, Tim De Pooter, Wouter De Coster, Mojca Strazisar, Charles Van der Henst   +10 more
doaj   +1 more source

Saleability of Anti-malarials in Private Drug Shops in Muheza, Tanzania: A Baseline study in an era of assumed Artemisinin Ccombination Therapy (ACT). [PDF]

, 2011
Artemether-lumefantrine (ALu) replaced sulphadoxine-pymimethamine (SP) as the official first-line anti-malarial in Tanzania in November 2006. So far, artemisinin combination therapy (ACT) is contra-indicated during pregnancy by the national malaria ...
AM Rønn, B Wasunna, C Goodman, C Goodman, DS Tarimo, DS Tarimo, FM Ringsted, Frank M Ringsted, Ib C Bygbjerg, Isolide S Massawe, J Eriksen, M Alifrangis, M Alifrangis, Martha M Lemnge, Ministry of Health and Social Welfare URoT, MM Lemnge, MS Alilio, S Alba, S Alba, SE Nsimba, SE Nsimba, SE Nsimba, United Republic of Tanzania, VR Kamat, WE Harrington, World Health Organization, Z Premji   +26 more
core   +4 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Identification of Mycobacterium tuberculosis intracellular survival-related virulence factors via CRISPR-based eukaryotic-like secretory protein mutant library screen

Microbiology Spectrum
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains a serious infectious disease posing significant global health challenges. A critical evolutionary feature of M.tb is its genome encoding a set of eukaryotic-like secretory proteins ...
Weiyi Liu, Yingchao Wang, Jiayuan Zhao, Xinyue Zhang, Zihui Li, Hongyan Jia, Chuanzhi Zhu, Lanyue Zhang, Liping Pan, Zongde Zhang   +9 more
doaj   +1 more source

The spread of antimalarial drug resistance: A mathematical model with practical implications for ACT drug policies [PDF]

, 2008
Most malaria-endemic countries are implementing a change in antimalarial drug policy to artemisinin combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Arjen Dondorp, Ian Hastings, Nicholas Day, Nicholas White, Shunmay Yeung, Wirichada Pongtavornpinyo   +5 more
core   +1 more source

Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter [PDF]

, 1967
Adverse side effects of cancer agents are of great concern in the context of childhood tumors where they can reduce the quality of life in young patients and cause life-long adverse effects.
Brunak, Søren, Halasz, Melinda, Huber, Kilian V.M., Kolch, Walter, Papamarkou, Theodore, Radic-Sarikas, Branka, Superti-Furga, Giulio, Tsafou, Kalliopi P., Winter, Georg E.   +8 more
core   +3 more sources