Results 121 to 130 of about 5,086,971 (309)
Turkish Journal of Hematology, 2017 Objective: Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disease in adults. The aim of this study is to find out if the extent of proliferation centers or the immunohistochemical expression of p53 is related to disease ...
İbrahim Kulaç +4 more
doaj +1 more source
Drug resistance in tuberculosis [PDF]
European Respiratory Journal, 2005 A drug-resistant strain ofMycobacterium tuberculosisis defined as one differing from the tight distribution of wild strains that have not come into contact with the drug concerned.Sensitivity tests are performed by the absolute concentration method, the resistance ratio method or the proportion method. The hypothesis underlying the proportion method is
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Zinc pyrithione impairs iron-sulfur cluster biogenesis in Mycobacterium tuberculosis
BMC MicrobiologyBackground Tuberculosis remains a major global health threat, especially with the increasing prevalence of drug-resistant Mycobacterium tuberculosis (Mtb). There is an urgent need to develop new antibiotics with novel mechanisms of action.
Lu Wang +6 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Comparative genomic analyses of Escherichia coli ST405 strains from Pakistan
mSystemsEscherichia coli sequence type (ST) 405, a high-risk international clone, has emerged as a critical lineage for the dissemination of antibiotic resistance genes (ARGs), including the blaNDM-5 gene.
Nam-Hoon Kim +11 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
BMC Veterinary ResearchBackground The global spread of multidrug-resistant (MDR) bacteria prompts the exploration of innovative antimicrobial strategies. Phage lysins—peptidoglycan hydrolases known for species-specific activity and low resistance potential—offer promising ...
Jiaqi Zhao +8 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source