Results 101 to 110 of about 5,086,971 (309)

Understanding cisplatin resistance using cellular models [PDF]

, 2007
Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, M, Davey, Mary W., Davey, Mary W, Stordal, B, Britta Stordal, Mary Davey, Stordal, Britta, Stordal, B., Davey, M.   +8 more
core   +2 more sources

Efficacy of regimens targeting Mycobacterium abscessus in vitro and in vivo

BMC Microbiology
Background M. abscessus (Mabs) is one of the principal pathogenic strains among nontuberculous mycobacterial. Mabs infections pose a significant global public health challenge, leading to substantial morbidity and mortality. However, a standard treatment
Zimo Wang, Yangxue Ye, Weiyan Zhang, Bin Wang, Xiaoyou Chen, Yu Lu   +5 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa. [PDF]

, 2014
In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and
Martin Antonio, Odin Goovaerts (138054), Martin Gninafon, Lingoupou, Fanny M, Elie Nduwamahoro (672710), Juergen Noeske (672717), Alberto Piubello (672716), Ba, Fatoumata, Cécile Uwizeye (5661748), Elie Nduwamahoro, Martin Antonio (42317), Gehre, Florian, Oumou Sow (672713), Sow, Oumou, Dissou Affolabi (470788), Kristina Fissette (672709), Gninafon, Martin, Bouke C de Jong, Sarr, Marie, Dissou Affolabi, Uwizeye, Cécile, Alberto Piubello, Mebrat Ejo, Ejo, Mebrat, de Rijk, Pim, Fanny M Lingoupou, Kristina Fissette, Merle, Corinne, Leen Rigouts (62768), Nduwamahoro, Elie, Odin Goovaerts, Mamadou Dian Barry, Barry, Mamadou Dian, Martin Gninafon (561425), Affolabi, Dissou, Goovaerts, Odin, Marie Sarr, Florian Gehre, Pim de Rijk (377868), Noeske, Juergen, Oumou Sow, Cécile Uwizeye, Fanny M. Lingoupou (672711), Piero Olliaro (35337), Fissette, Kristina, Piubello, Alberto, Corinne Merle, Florian Gehre (182718), Mamadou Dian Barry (672712), Marie Sarr (672715), Rigouts, Leen, Piero Olliaro, Fatoumata Ba, Corinne Merle (514025), Mebrat Ejo (672708), Juergen Noeske, Fatoumata Ba (672714), de Jong, Bouke C, Pim de Rijk, Bouke C de Jong (378876), Olliaro, Piero, Leen Rigouts, Antonio, Martin   +62 more
core   +1 more source

Updated Erdman reveals tandem repeat copy number is phase-variable and impacts M. tuberculosis adaptation across evolutionary timescales

mSystems
High-quality reference genomes are essential for comparative genomics and accurate genotype-phenotype mapping. Here, we corrected the Mycobacterium tuberculosis Erdman strain reference genome (ErdmanTI) using ultra-deep HiFi sequencing.
Samuel J. Modlin, Nachiket Thosar, Paulina M. Mejía-Ponce, Raegan L. Lunceford, Gaelle Guiewi Makafe, Brian Weinrick, Faramarz Valafar   +6 more
doaj   +1 more source

Relapse Versus Reinfection of Recurrent Tuberculosis Patients in a National Tuberculosis Specialized Hospital in Beijing, China

Frontiers in Microbiology, 2018
Tuberculosis (TB) recurrence can result from either relapse of an original infection or exogenous reinfection with a new strain of Mycobacterium tuberculosis (MTB).
Zhaojing Zong, Fengmin Huo, Jin Shi, Wei Jing, Yifeng Ma, Qian Liang, Guanglu Jiang, Guangming Dai, Hairong Huang, Yu Pang   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Evolution of antibiotic resistance at non-lethal drug concentrations

, 2012
Human use of antimicrobials in the clinic, community and agricultural systems has driven selection for resistance in bacteria. Resistance can be selected at antibiotic concentrations that are either lethal or non-lethal, and here we argue that selection ...
Andersson, Dan I,, Hughes, Diarmaid,
core   +1 more source