Results 141 to 150 of about 1,288,674 (265)

Drug Resistance in Malaria [PDF]

BMJ, 1953
openaire   +3 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Border Region Surveillance of Malaria Drug Resistance, Northern Burundi, 2023-2024. [PDF]

Emerg Infect Dis
Niyomwungere D, Sinarinzi P, Caspar E, Thiebaut L, Strubel PE, Tibiri YNG, Ma L, Rurihafi J, Ndizeyimana P, Hakizimana P, Niyizompa N, Witonze A, Ndayiragije V, Ndayisenga F, Ndikumukiza M, Niyonkuru O, Niyonsaba JC, Bangirinama C, Bigirimana JL, Ntahondi N, Mugisha L, Nibakire M, Nzoyikorera N, Sinzinkayo D, Menard D, Nyandwi J.   +25 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Artificial Sweeteners Induce Bacterial Drug Resistance and Modulate Gene Expression. [PDF]

Infect Drug Resist
Jin X, Xu J, Cao Y, Dai Z, Wang R, Ge X, Cai R, Hu Z, Sun X, Chen J, Zhang L.   +10 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Candida Drug Resistance in Patients With Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis. [PDF]

Int Wound J
Ekvan MH, Sayyadi H, Alidadpour S, Karimi M, Getso MI, Ebrahimi AR, Mirpanahi M, Raiesi O.   +7 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Decoding Drug Resistance in Pancreatic Cancer: A Subcellular Structure Perspective. [PDF]

Biology (Basel)
Li X, Lyu H, Wu Y, Chen A, Wu G, Zhang R, Xiao S, Guo D, Zhang Q, Yan C, Tang J, Zhou C.   +11 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source