Results 141 to 150 of about 2,311,261 (354)

HIV‐1 transmitted drug resistance surveillance: shifting trends in study design and prevalence estimates [PDF]

, 2020
Soo‐Yon Rhee, Seble Kassaye, Geoffrey Barrow, Jagadish Chandrabose Sundaramurthi, Michael R. Jordan, Robert W. Shafer   +5 more
openalex   +1 more source

Predicting drug resistance

eLife
A new approach helps examine the proportion of cancerous and healthy stem cells in patients with chronic myeloid leukemia and how this influences treatment outcomes.
Nicole S Arellano, Shannon E Elf
openaire   +3 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Relationship Between Drug Resistance and Death in HIV-Infected Patients Receiving Antiretroviral Therapy — 7 PLADs, China, 2010−2019 [PDF]

, 2021
Tianhao Zhang, Lingjie Liao, Yiming Shao, Yi Feng, Yuhua Ruan, Hui Xing   +5 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Hybrid sequencing of chromosome and plasmids from multidrug-resistant Escherichia coli isolated in Cambodia: Are megaplasmids vectors of antibiotic resistance genes?

Journal of Global Antimicrobial Resistance
Objectives: The prevalence of antimicrobial resistance (AMR) in Escherichia coli infections in Cambodia is high and increasing, yet data distinguishing plasmid- and chromosome-mediated AMR spread remain limited.
Ella Marcy, Sivhour Chiek, Mallorie Hidé, Savatey Hak, Chiva Ma, Meymey Lem, Gauthier Delvallez, Anne-Laure Bañuls, Sokleaph Cheng, Juliette Hayer   +9 more
doaj   +1 more source

Detection of the Resistance of Parasite to Sulfadoxine-pyrimethamine Drugs and msp-2 Genotyping as A Baseline in Developing Malaria Vaccine with Ionizing Radiation [PDF]

, 2019
Mukh Syaifudin, Harry Nugroho Eko Surniyantoro, Teja Kisnanto, Antonius Oktavian, Puji Budi Setia Asih   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Population genetic approaches to estimating the size of the HIV reservoir

Journal of Virus Eradication, 2015
J. Hattori, V. Boltz, W. Shao, M. Kearney, F. Maldarelli   +4 more
doaj   +1 more source

The alert for emergence of pig-associated MRSA ST 398 in multi-regions China

One Health
Livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA) lineage ST398 presents a notable public health risk through its transmission from pigs to humans.
Mingquan Cui, Hejia Wang, Ningning Han, Wenli Tang, Xiangbin Song   +4 more
doaj   +1 more source