Results 161 to 170 of about 7,313,278 (356)

Recombination Between a Thermosensitive Kanamycin Resistance Factor and a Nonthermosensitive Multiple-Drug Resistance Factor [PDF]

, 1969
Takeshi Yokota, Yoshiro Kanamaru, Reiko Mori, Tomoichiro Akiba   +3 more
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Commentary: Malaria elimination in India and regional implications

Frontiers in Microbiology, 2018
Kwang Seung Park, Sumera Kausar Malik, Jung Hee Lee, Asad Mustafa Karim, Asad Mustafa Karim, Sang Hee Lee   +5 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Characteristics and treatment outcomes of patients with multi-drug-resistant tuberculosis at Abbassia Chest Hospital

The Egyptian Journal of Bronchology
Background Multi-drug-resistant tuberculosis (MDR-TB) remains a significant health concern. This study analyzes patients admitted to Abbassia Chest Hospital, focusing on their characteristics, drug resistance patterns, treatment outcomes, and risk ...
Ibrahim Mostafa Mohamed Nofal, Hesham Atef AbdelHalim, Ashraf Abbass Almaraghy, Amr Mohammed Awad, Mohamed Ali Farrag   +4 more
doaj   +1 more source

Drug Resistance in Salmonella Typhimurium and its Implications [PDF]

, 1968
E. S. Anderson
openalex   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Studies on the antibacterial action of streptomycin against tubercle bacilli as a possible mitotic poison, with particular reference to the development of drug-resistance. Tuberculosis Division

, 1955
KOOMI KANAI
openalex   +2 more sources

IN VIVO TRANSMISSION OF DRUG RESISTANCE FACTORS BETWEEN STRAINS OF STAPHYLOCOCCUS AUREUS [PDF]

, 1967
Richard P. Novick, Stephen I. Morse
openalex   +1 more source