Results 51 to 60 of about 1,025,188 (216)
Molecules, 2021 A series of novel functionalized methyl 3-(hetero)arylthieno[3,2-b]pyridine-2-carboxylates 2a–2h were synthesized by C-C Pd-catalyzed Suzuki-Miyaura cross-coupling of methyl 3-bromothieno[3,2-b]pyridine-2-carboxylate with (hetero)aryl pinacol boranes ...
Bruna R. Silva +5 more
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Trends in Parasitology, 2005 In the past 21 years, a modest increase in the range of antimalarial drugs approved for clinical use has been complemented by a more impressive expansion in the analysis and understanding of the molecular mechanisms underlying resistance to these agents.
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BMJ, 2007 HIV has an impressive ability to replicate, mutate, and diversify, so developing drugs or vaccines that can fully contain the virus is a challenge. The only consistently successful way to prevent replication of HIV is to administer a potent combination regimen that contains at least two and preferably three antiretroviral drugs.
Steven G. Deeks, Hiroyu Hatano
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Frontiers in MicrobiologyBackgroundRifampicin (RIF) is a key first-line drug used to treat tuberculosis, a primarily pulmonary disease caused by Mycobacterium tuberculosis. RIF resistance is caused by mutations in rpoB, at the cost of slower growth and reduced transcription ...
Derek Conkle-Gutierrez +7 more
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Drug resistance in malaria [PDF]
British Medical Bulletin, 1998 Drug resistance in malaria is now widespread and in many parts of the world is making treatment increasingly difficult. This article reviews current knowledge of the mechanisms and extent of resistance of Plasmodium falciparum and P. vivax to the available antimalarial drugs, and the recommendations for treating malaria in regions where resistance is ...
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MicroRNA and drug resistance [PDF]
Cancer Gene Therapy, 2010 Chemotherapy is the preferred treatment for malignancies. However, a successful long-term use of chemotherapy is often prevented by the development of drug resistance. Many mechanisms such as gene mutation, DNA methylation and histone modification have important roles in the resistance of cancer cells to chemotherapeutic agents.
C Ji, J Ma, C Dong
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Journal of Enzyme Inhibition and Medicinal ChemistryThe urgent demand for effective countermeasures against metallo-β-lactamases (MBLs) necessitates development of novel metallo-β-lactamase inhibitors (MBLIs).
Jung Hun Lee +7 more
doaj +1 more source
Frontiers in Microbiology, 2018 Tuberculosis (TB) recurrence can result from either relapse of an original infection or exogenous reinfection with a new strain of Mycobacterium tuberculosis (MTB).
Zhaojing Zong +9 more
doaj +1 more source
Using machine learning and big data to explore the drug resistance landscape in HIV.
PLoS Computational Biology, 2021 Drug resistance mutations (DRMs) appear in HIV under treatment pressure. DRMs are commonly transmitted to naive patients. The standard approach to reveal new DRMs is to test for significant frequency differences of mutations between treated and naive ...
Luc Blassel +6 more
doaj +1 more source
HIV drug resistance: problems and perspectives [PDF]
arXiv, 2012 Access to combination antiretroviral treatment (ART) has improved greatly over recent years. At the end of 2011, more than eight million HIV infected people were receiving antiretroviral therapy in low-income and middle-income countries. ART generally works well in keeping the virus suppressed and the patient healthy.
arxiv