Results 41 to 50 of about 1,255,487 (165)

Relapse Versus Reinfection of Recurrent Tuberculosis Patients in a National Tuberculosis Specialized Hospital in Beijing, China

Frontiers in Microbiology, 2018
Tuberculosis (TB) recurrence can result from either relapse of an original infection or exogenous reinfection with a new strain of Mycobacterium tuberculosis (MTB).
Zhaojing Zong, Fengmin Huo, Jin Shi, Wei Jing, Yifeng Ma, Qian Liang, Guanglu Jiang, Guangming Dai, Hairong Huang, Yu Pang   +9 more
doaj   +1 more source

TP53 Staining in Tissue Samples of Chronic Lymphocytic Lymphoma Cases: An Immunohistochemical Survey of 51 Cases

Turkish Journal of Hematology, 2017
Objective: Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disease in adults. The aim of this study is to find out if the extent of proliferation centers or the immunohistochemical expression of p53 is related to disease ...
İbrahim Kulaç, Çetin Demir, Yahya Büyükaşık, Tezer Kutluk, Aysegül Üner   +4 more
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Antimalarial drug resistance [PDF]

Journal of Clinical Investigation, 2004
Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill between one and two million people, mainly children, each year. Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for a recent increase in malaria-related mortality, particularly in Africa.
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HIV Drug Resistance

New England Journal of Medicine, 2004
Combinations of antiretroviral drugs have proven remarkably effective in controlling the progression of HIV disease and prolonging survival, but these benefits can be compromised by the development of drug resistance. About 50 percent of patients receiving antiretroviral therapy in the United States are estimated to harbor viruses that express ...
François, Clavel, Allan J, Hance
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Efficacy of carrimycin against Mycobacterium avium complex in vitro and in vivo

Microbiology Spectrum
Mycobacterium avium complex (MAC) is one of the principal pathogenic strains among nontuberculous mycobacteria. Current antibiotics have poor microbiological responses, and repurposed antibiotics are a way to meet clinical needs.
Zimo Wang, Xiaodong Li, Weiyan Zhang, Lei Fu, Xinda Li, Xiaoyou Chen, Yu Lu   +6 more
doaj   +1 more source

Quantitative analysis of the lysine acetylome reveals the role of SIRT3-mediated HSP60 deacetylation in suppressing intracellular Mycobacterium tuberculosis survival

Microbiology Spectrum
Protein acetylation and deacetylation are key epigenetic modifications that regulate the initiation and development of several diseases. In the context of infection with Mycobacterium tuberculosis (M.
Chuanzhi Zhu, Yuheng Duan, Jing Dong, Hongyan Jia, Lanyue Zhang, Aiying Xing, Zihui Li, Boping Du, Qi Sun, Yinxia Huang, Zongde Zhang, Liping Pan   +11 more
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The pharmacokinetics (PK) / pharmacodynamics (PD) of pretomanid, delamanid and bedaquiline in the BALB/c mouse model of central nervous system tuberculosis

BMC Infectious Diseases
Background Central nervous system tuberculosis (CNS-TB) is one of the most destructive diseases with high morbidity and mortality worldwide. The present study aimed to assess the effect of three anti-tuberculosis drugs, pretomanid (PA-824), delamanid ...
Hui Zhu, Yangxue Ye, Lei Fu, Weiyan Zhang, Bin Wang, Xi Chen, Yu Lu   +6 more
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Zinc pyrithione impairs iron-sulfur cluster biogenesis in Mycobacterium tuberculosis

BMC Microbiology
Background Tuberculosis remains a major global health threat, especially with the increasing prevalence of drug-resistant Mycobacterium tuberculosis (Mtb). There is an urgent need to develop new antibiotics with novel mechanisms of action.
Lu Wang, Xuelin Wang, Lingling Xu, Bin Wang, Deqian Ji, Yangxue Ye, Yu Lu   +6 more
doaj   +1 more source

Machine learning reveals targets of Gnaphalium hypoleucum DC. flavonoids against rheumatoid arthritis through gut microbiota and anti-inflammation

Frontiers in Immunology
BackgroundRheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and gut microbiota dysbiosis. Gnaphalium hypoleucum DC.
Yu-Long Li, Zi-Yong Chu, Ding-Hui Xu, Ding-Hui Xu, Shu-Yun Wei, Ya-Si Nong, Xiao-Xi Luo, Yi-Jing Wang, Hong Zeng   +8 more
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Introduction: Drug Resistance [PDF]

Chemical Reviews, 2021
Nese Kurt Yilmaz, Celia A. Schiffer
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