Results 61 to 70 of about 1,025,188 (216)
Critical behavior of an epidemic model of drug resistant diseases [PDF]
, 2003 In this work, we study the critical behavior of an epidemic propagation model that considers individuals that can develop drug resistance. In our lattice model, each site can be found in one of four states: empty, healthy, normally infected (not drug resistant) and strain infected (drug resistant) states.
arxiv +1 more source
Turkish Journal of Hematology, 2017 Objective: Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disease in adults. The aim of this study is to find out if the extent of proliferation centers or the immunohistochemical expression of p53 is related to disease ...
İbrahim Kulaç +4 more
doaj +1 more source
Slowing evolution is more effective than enhancing drug development for managing resistance [PDF]
arXiv, 2013 Drug resistance is a serious public health problem that threatens to thwart our ability to treat many infectious diseases. Repeatedly, the introduction of new drugs has been followed by the evolution of resistance. In principle there are two ways to address this problem: (i) enhancing drug development, and (ii) slowing drug resistance.
arxiv
Journal of Cardiothoracic SurgeryBackground The gastric conduit is the most commonly used replacement organ for reconstruction after minimally invasive McKeown esophagectomy. Although the optimal route of gastric conduit remains controversial, the posterior mediastinal route is ...
Zhaoyang Yan +8 more
doaj +1 more source
Standing genetic variation and the evolution of drug resistance in HIV [PDF]
, 2011 Drug resistance remains a major problem for the treatment of HIV. Resistance can occur due to mutations that were present before treatment starts or due to mutations that occur during treatment. The relative importance of these two sources is unknown.
arxiv +1 more source
VirulenceOver the last decade, there has been a steady increase in HIV-1 prevalence in Mizoram, India. Importantly, this increase in HIV-1 prevalence is not only limited to the key population groups such as female sex workers (FSWs) or people who inject drugs ...
Komal Raskar +8 more
doaj +1 more source
Prospect for application of mathematical models in combination cancer treatments [PDF]
arXiv, 2020 The long-term efficacy of targeted therapeutics for cancer treatment can be significantly limited by the type of therapy and development of drug resistance, inter alia. Experimental studies indicate that the factors enhancing acquisition of drug resistance in cancer cells include cell heterogeneity, drug target alteration, drug inactivation, DNA damage
arxiv
Clonal Diversity at Cancer Recurrence [PDF]
arXiv, 2021 Despite initial success, cancer therapies often fail due to the emergence of drug-resistant cells. In this study, we use a mathematical model to investigate how cancer evolves over time, specifically focusing on the state of the tumor when it recurs after treatment.
arxiv
Enzymatic Studies on the Mechanism of the Resistance of Pneumococcus to Drugs [PDF]
, 1948 M. G. Sevag, Joseph S. Gots
openalex +3 more sources
Convection shapes the trade-off between antibiotic efficacy and the selection for resistance in spatial gradients [PDF]
, 2017 Since penicillin was discovered about 90 years ago, we have become used to using drugs to eradicate unwanted pathogenic cells. However, using drugs to kill bacteria, viruses or cancer cells has the serious side effect of selecting for mutant types that survive the drug attack.
arxiv +1 more source