Results 61 to 70 of about 7,313,278 (356)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Circulating Epstein-Barr virus DNA and cell-free DNA in pediatric lymphomas

The Turkish Journal of Pediatrics, 2020
Background and Objectives. Quantification of serum Epstein-Barr virus (EBV) DNA and/or cell-free total DNA (cf-DNA) may become valuable sources for prognosis evaluation and monitoring treatment response in lymphomas.
Bilgehan Yalçın, Tezer Kutluk, Serpil Kahraman Ağbaba, Çetin Demir, Beril Talim   +4 more
doaj   +1 more source

Targeting autophagy to overcome drug resistance: further developments

Journal of Hematology & Oncology, 2020
Inhibiting cell survival and inducing cell death are the main approaches of tumor therapy. Autophagy plays an important role on intracellular metabolic homeostasis by eliminating dysfunctional or unnecessary proteins and damaged or aged cellular ...
Haocai Chang, Zhengzhi Zou
semanticscholar   +1 more source

Glycosphingolipids and drug resistance

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006
Drug resistance, an all too frequent characteristic of cancer, represents a serious barrier to successful treatment. Although many resistance mechanisms have been described, those that involve membrane-resident proteins belonging to the ABC (ATP binding cassette) transporter superfamily are of particular interest.
Myles C. Cabot, Valérie Gouazé-Andersson   +1 more
openaire   +3 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Interred mechanisms of resistance and host immune evasion revealed through network-connectivity analysis of M. tuberculosis complex graph pangenome

mSystems
Mycobacterium tuberculosis complex successfully adapts to environmental pressures through mechanisms of rapid adaptation which remain poorly understood despite knowledge gained through decades of research.
Monica E. Espinoza, Ashley M. Swing, Afif Elghraoui, Samuel J. Modlin, Faramarz Valafar   +4 more
doaj   +1 more source

Phenotypic Characterization and Heterogeneity among Modern Clinical Isolates of Acinetobacter baumannii

Microbiology Spectrum, 2023
Acinetobacter baumannii is an opportunistic pathogenic bacterium prioritized by WHO and CDC because of its increasing antibiotic resistance. Heterogeneity among strains represents the hallmark of A. baumannii bacteria.
Adam Valcek, Chantal Philippe, Clémence Whiteway, Etienne Robino, Kristina Nesporova, Mona Bové, Tom Coenye, Tim De Pooter, Wouter De Coster, Mojca Strazisar, Charles Van der Henst   +10 more
doaj   +1 more source

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Molecular Cancer, 2019
Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion, metastasis and drug-resistance.
Ladan Mashouri, Hassan Yousefi, A. Aref, A. Ahadi, F. Molaei, S. Alahari   +5 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Phylodynamic analysis reveals CRF01_AE dissemination between Japan and neighboring Asian countries and the role of intravenous drug use in transmission. [PDF]

PLoS ONE, 2014
BACKGROUND: One major circulating HIV-1 subtype in Southeast Asian countries is CRF01_AE, but little is known about its epidemiology in Japan. We conducted a molecular phylodynamic study of patients newly diagnosed with CRF01_AE from 2003 to 2010 ...
Teiichiro Shiino, Junko Hattori, Yoshiyuki Yokomaku, Yasumasa Iwatani, Wataru Sugiura, Japanese Drug Resistance HIV-1 Surveillance Network   +5 more
doaj   +1 more source