Results 71 to 80 of about 1,025,188 (216)
Infectious Diseases and Therapy, 2020 Introduction To evaluate the value of the combination of computed tomography (CT)-guided percutaneous lung biopsy and Xpert MTB/RIF Ultra (Xpert-Ultra) in enhancing the differential diagnosis of tuberculosis.
Zhen Zhou +10 more
doaj +1 more source
Freshwater viral metagenome reveals novel and functional phage-borne antibiotic resistance genes
Microbiome, 2020 Background Antibiotic resistance developed by bacteria is a significant threat to global health. Antibiotic resistance genes (ARGs) spread across different bacterial populations through multiple dissemination routes, including horizontal gene transfer ...
Kira Moon +7 more
doaj +1 more source
Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model [PDF]
arXiv, 2014 Practically, all chemotherapeutic agents lead to drug resistance. Clinically, it is a challenge to determine whether resistance arises prior to, or as a result of, cancer therapy. Further, a number of different intracellular and microenvironmental factors have been correlated with the emergence of drug resistance.
arxiv
Microbiology SpectrumProtein acetylation and deacetylation are key epigenetic modifications that regulate the initiation and development of several diseases. In the context of infection with Mycobacterium tuberculosis (M.
Chuanzhi Zhu +11 more
doaj +1 more source
Susceptibility of Methicillin Resistant Staphylococcus aureus to Vancomycin using Liposomal Drug Delivery System [PDF]
arXiv, 2018 Staphylococcus aureus responsible for nosocomial infections is a significant threat to the public health. The increasing resistance of S.aureus to various antibiotics has drawn it to a prime focus for research on designing an appropriate drug delivery system.
arxiv
Using Genomics to Track Global Antimicrobial Resistance
Frontiers in Public Health, 2019 The recent advancements in rapid and affordable DNA sequencing technologies have revolutionized diagnostic microbiology and microbial surveillance. The availability of bioinformatics tools and online accessible databases has been a prerequisite for this.
Rene S. Hendriksen +5 more
doaj +1 more source
The WHO surveillance threshold and the emergence of drug-resistant HIV strains in Botswana [PDF]
arXiv, 2005 Background: Approximately 40% of adults in Botswana are HIV-infected. The Botswana antiretroviral program began in 2002 and currently treats 34,000 patients with a goal of treating 85,000 patients (~30% of HIV-infected adults) by 2009. We predict the evolution of drug-resistant strains of HIV that may emerge as a consequence of this treatment program ...
arxiv
Murine Leukemia Viruses: Objects and Organisms
Advances in Virology, 2011 Murine leukemia viruses (MLVs) are among the simplest retroviruses. Prototypical gammaretroviruses encode only the three polyproteins that will be used in the assembly of progeny virus particles.
Alan Rein
doaj +1 more source
Predicting trajectories and mechanisms of antibiotic resistance evolution [PDF]
arXiv, 2020 Bacteria evolve resistance to antibiotics by a multitude of mechanisms. A central, yet unsolved question is how resistance evolution affects cell growth at different drug levels. Here we develop a fitness model that predicts growth rates of common resistance mutants from their effects on cell metabolism. We map metabolic effects of resistance mutations
arxiv
mSphereSudapyridine (WX-081) is a structural analog of bedaquiline (BDQ), which shows anti-tuberculosis and non-tuberculous mycobacteria (NTM) activities but, unlike BDQ, did not prolong QT interval in animal model studies.
Luyao Zheng +8 more
doaj +1 more source