Results 101 to 110 of about 4,670,790 (255)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Low-cost rapid detection of rifampicin resistant tuberculosis using bacteriophage in Kampala, Uganda. [PDF]

, 2007
BACKGROUND: Resistance to anti-tuberculosis drugs is a serious public health problem. Multi-drug resistant tuberculosis (MDR-TB), defined as resistance to at least rifampicin and isoniazid, has been reported in all regions of the world.
Traore, Hamidou, Hamidou Traore, Jones-Lopez, Edward C, McNerney, Ruth, Eisenach Kathleen D, Joloba, Moses L, Jones-Lopez Edward C, Roy D Mugerwa, Smith, Peter G, Mugerwa, Roy D, Ogwang Sam, Smith Peter G, Moses L Joloba, Mallard, Kim, Kathleen D Eisenach, Jerrold J Ellner, Ellner, Jerrold J, Eisenach, Kathleen D, Ogwang, Sam, Mugerwa Roy D, Kayes, Susan, McNerney Ruth, Edward C Jones-Lopez, Kalpana Narayan, Ruth McNerney, Peter G Smith, Sam Ogwang, Susan Kayes, Joloba Moses L, Narayan, Kalpana, Francis Mumbowa, Narayan Kalpana, Ellner Jerrold J, Mumbowa, Francis, Kayes Susan, Kim Mallard, Traore Hamidou, Mumbowa Francis, Mallard Kim   +38 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Antiretroviral drug resistance mutations among patients failing first-line treatment in Hanoi, Vietnam

, 2019
Tran Viet Tien,1 Dinh Cong Pho,2 Le Thu Hong,3 Hien Pham Ba,4 Le Van Nam,1 Pham Ngoc Hung5,61Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, Hanoi City, Vietnam; 2Faculty of Medicine, Vietnam Military ...
Hong LT, Nam LV, Ba HP, Pho DC, Hung PN, Tien TV   +5 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Detection of BCR-ABL kinase domain mutations in CD34+ cells from newly diagnosed chronic phase CML patients and their association with imatinib resistance [PDF]

, 2011
BCR-ABL kinase domain (KD) mutations, the most common cause of imatinib resistance, are infrequently detected in newly diagnosed chronic-phase chronic myeloid leukemia (CP-CML) patients.
Riaz ul-Haq, Abdul Qayyum, Mubashar Naqvi, Tariq Gill, Muhammad Khalid, Ammara Tahir, Abid Jamil, Ahmad Khalid, Mahwish Khan, Muhammad Ferhan, Ijaz Shah, Abid Taj, Weng Qin, Mudassar Iqbal, Muhammad Abbad, Aamer Aleem, Tanveer Akhtar, Zafar Iqbal, Najeeb ur-Rehman, Shahid Baig   +19 more
core  

Molecular footprint of drug-selective pressure in a human immunodeficiency virus transmission chain [PDF]

, 2005
Known human immunodeficiency virus (HIV) transmission histories are invaluable models for investigating the evolutionary and transmission dynamics of the virus and to assess the accuracy of phylogenetic reconstructions.
A.-M. Vandamme, Lemey, P, A. Rambaut, Dumont, Stephanie, S. Dumont, Van Wijngaerden, Eric, Vandamme, A M, K. Van Laethem, Rambaut, Andrew, Vermeulen, Steve, S. Vermeulen, E. Van Wijngaerden, Dumont, S, Vandamme, Anne-Mieke, P. Lemey, Rambaut, A, Van Laethem, Kristel, Lemey, Philippe, I. Derdelinckx, Van Wijngaerden, E, Derdelinckx, Inge, Vermeulen, S, Van Laethem, K, Derdelinckx, I   +23 more
core   +1 more source