Results 81 to 90 of about 4,670,790 (255)

Drug resistance maps to guide intermittent preventive treatment of malaria in African infants. [PDF]

, 2011
Intermittent preventive treatment of infants (IPTi) with sulphadoxine pyrimethamine (SP) is recommended as an additional malaria control intervention in high transmission areas of sub-Saharan Africa, provided its protective efficacy is not compromised by
CALLY ROPER, Naidoo, Inbarani, Roper, Cally, INBARANI NAIDOO   +3 more
core   +1 more source

Large-scale genomic analysis of Mycobacterium tuberculosis reveals extent of target and compensatory mutations linked to multi-drug resistant tuberculosis

Scientific Reports, 2023
Resistance to isoniazid (INH) and rifampicin (RIF) first-line drugs in Mycobacterium tuberculosis (Mtb), together called multi-drug resistance, threatens tuberculosis control.
Gary Napier, Susana Campino, Jody E. Phelan, Taane G. Clark   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Kamugisha, Erasmus, Piola, Patrice, Faucher, Jean-François, El-Sayed, Badria, Houzé, Sandrine, Somé, A Fabrice, Sutherland, Colin, Checchi, Francesco, Plowe, Christopher, V, Sutherland, Colin J, Otienoburu, Sabina Dahlström, Berens-Riha, Nicole, Grivoyannis, Anastasia, Davis, Timothy ME, Björkman, Anders, Asaq Molecular Marker Study Group, Rosenthal, Philip, Eyase, Frederick, Malmberg, Maja, Kariuki, Simon, Mårtensson, Andreas,, Hamour, Sally, Ogutu, Bernhards, Davis, Timothy, Wong, Rina, Sibley, Carol Hopkins, Gadalla, Nahla B, Ngasala, Billy, Ménard, Didier, Oguike, Mary, Venkatesan, Meera, Arze, Cesar, Djimdé, Abdoulaye A, Baliraine, Frederick N, Fröberg, Gabrielle, Ursing, Johan, LeBras, Jacques, Desai, Meghna, Mårtensson, Andreas, Ouédraogo, Jean-Bosco, El-Sayed, Badria B, Mwai, Leah, Thwing, Julie, Kironde, Fred, Djimde, Abdoulaye, Price, Ric, Dorsey, Grant, Johnson, Jacob, Guérin, Philippe, Somé, A. Fabrice, Oguike, Alexis Nzila Mary, LeBras, Poul-Erik Kofoed Jacques, Moriera, Clarissa, Kiechel, Jean-René, Kofoed, Poul-Erik, Dahal, Prabin, Nsanzabana, Christian, Nzila, Alexis, Wong, Rina PM, Rosenthal, Philip J, Ademowo, George, Falade, Catherine, Nsobya, Samuel L, Schramm, Birgit, Zongo, Issaka, Gadalla, Nahla, Wong, Rina P M, Plowe, Christopher V, Eshetu, Teferi, Davis, Timothy M E, Dhorda, Meghna Desai Mehul, Plowe, Christopher,, Rombo, Lars,, Dhorda, Mehul, Stepniewska, Kasia, Adam, Ishag, Price, Ric N, Borrmann, Steffen, Nosten, Francois, Rombo, Lars, Baliraine, Frederick, Zeynudin, Ahmed, Nsobya, Samuel   +82 more
core   +1 more source

Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients

Retrovirology, 2012
Background The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free environment, and therefore are expected to ...
Theys Kristof, Deforche Koen, Vercauteren Jurgen, Libin Pieter, van de Vijver David AMC, Albert Jan, Åsjö Birgitta, Balotta Claudia, Bruckova Marie, Camacho Ricardo J, Clotet Bonaventura, Coughlan Suzie, Grossman Zehava, Hamouda Osamah, Horban Andrzei, Korn Klaus, Kostrikis Leondios G, Kücherer Claudia, Nielsen Claus, Paraskevis Dimitrios, Poljak Mario, Puchhammer-Stockl Elisabeth, Riva Chiara, Ruiz Lidia, Liitsola Kirsi, Schmit Jean-Claude, Schuurman Rob, Sönnerborg Anders, Stanekova Danica, Stanojevic Maja, Struck Daniel, Van Laethem Kristel, Wensing Annemarie MJ, Boucher Charles AB, Vandamme Anne-Mieke   +34 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Massively Parallel Profiling of HIV-1 Resistance to the Fusion Inhibitor Enfuvirtide

Viruses, 2019
Identifying drug resistance mutations is important for the clinical use of antivirals and can help define both a drug’s mechanism of action and the mechanistic basis of resistance. Resistance mutations are often identified one-at-a-time by studying
Adam S. Dingens, Dana Arenz, Julie Overbaugh, Jesse D. Bloom   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Intensity of transmission and spread of gene mutations linked to chloroquine and sulphadoxine-pyrimethamine resistance in falciparum malaria.

, 2003
The number of malaria parasite clones per infection-multiplicity of parasite clones-is affected by the transmission intensity, multiplicity increases with increasing transmission.
Hastings, Ian M, Langi, P., Talisuna, Ambrose O., Egwang, T.G., Mutabingwa, Theonest K., Speybroeck, Niko, Langi, P, Mutabingwa, T.K., Hastings, Ian, Talisuna, Ambrose O, Mutabingwa, Theonest K, Watkins, William W, Van Marck, E., Egwang, Thomas G, d' Alessandro, U., Egwang, TG, D'Alessandro, U., Egwang, T., Mutabingwa, T. K., Watkins, W.W., Langi, Peter, Mutabingwa, TK, Watkins, W. W., D'Alessandro, Umberto, Hastings, I. M., Hastings, IM, Speybroeck, N., Watkins, William W., Talisuna, A. O., Watkins, WW, Egwang, Thomas G., Van Marck, Eric, Talisuna, A.O., Van Marck, E, Talisuna, AO, Hastings, I.M.   +35 more
core   +1 more source