Results 71 to 80 of about 4,670,790 (255)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Population-Wide Emergence of Antiviral Resistance during Pandemic Influenza [PDF]

, 2008
Background: The emergence of neuraminidase inhibitor resistance has raised concerns about the prudent use of antiviral drugs in response to the next influenza pandemic.
Wu, Jianhong, Röst, Gergely, Moghadas Seyed M., Jianhong Wu, Christopher S Bowman, Wu Jianhong, Bowman, Christopher S., Galvani, Alison P., R\uf6st, Gergely, Moghadas, Seyed M., Gergely Röst, Seyed M Moghadas, Bowman Christopher S., Röst Gergely   +13 more
core   +2 more sources

Molecular Profiles of Multiple Antimalarial Drug Resistance Markers in Plasmodium falciparum and Plasmodium vivax in the Mandalay Region, Myanmar

Microorganisms, 2022
Emergence and spreading of antimalarial drug resistant malaria parasites are great hurdles to combating malaria. Although approaches to investigate antimalarial drug resistance status in Myanmar malaria parasites have been made, more expanded studies are
Hương Giang Lê, Haung Naw, Jung-Mi Kang, Tuấn Cường Võ, Moe Kyaw Myint, Zaw Than Htun, Jinyoung Lee, Won Gi Yoo, Tong-Soo Kim, Ho-Joon Shin, Byoung-Kuk Na   +10 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine. [PDF]

, 2015
BACKGROUND: In Nigeria, despite the change in National malaria drug policy to artemisinin combination therapy (ACT) in 2005 due to widespread chloroquine resistance, chloroquine (CQ) is still widely used in the treatment of malaria because it is cheap ...
Sutherland, Colin J, Oladipo, Oladosu O, Wellington, Oyibo A   +2 more
core   +1 more source

Leprosy Drug Resistance Surveillance in Colombia: The Experience of a Sentinel Country.

PLoS Neglected Tropical Diseases, 2016
An active search for Mycobacterium leprae drug resistance was carried out, 243 multibacillary patients from endemic regions of Colombia were included from 2004 to 2013 in a surveillance program. This program was a World Health Organization initiative for
Camilo Beltrán-Alzate, Fernando López Díaz, Marcela Romero-Montoya, Rama Sakamuri, Wei Li, Miyako Kimura, Patrick Brennan, Nora Cardona-Castro   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

HIV Drug Resistance (HIVDR) in Antiretroviral Therapy-Naïve Patients in Tanzania not Eligible for WHO Threshold HIVDR Survey is Dramatically High. [PDF]

, 2011
The World Health Organization (WHO) has recommended guidelines for a HIV drug resistance (HIVDR) survey for resource-limited countries. Eligibility criteria for patients include age below 25 years in order to focus on the prevalence of transmitted HIVDR (
Majinge, Charles, Mildner Miriam, Hartwig Klinker, Kasang Christa, Stich, August, Jacobs, Graeme Brendon, Graeme B Jacobs, Mildner, Miriam, Kalluvya, Samuel, Hensel, Irina, Gert van Zyl, Kongola Gilbert, Kalluvya Samuel, Hensel Irina, Mlewa, Mathias, Klinker, Hartwig, van Zyl, Gert, Miriam Mildner, van Zyl Gert, Christa Kasang, Mathias Mlewa, Wolfgang Preiser, Stich August, Bodem Jochen, Preiser, Wolfgang, Anne Horn, Klinker Hartwig, Eleni Koutsilieri, Kasang, Christa, Jacobs, Graeme B, Jochen Bodem, Scheller Carsten, Scheller, Carsten, Weissbrich Benedikt, Jacobs, Graeme B., Mlewa Mathias, Jacobs Graeme B., Koutsilieri, Eleni, Preiser Wolfgang, Charles Majinge, Koutsilieri Eleni, Irina Hensel, Rethwilm, Axel, Gilbert Kongola, Axel Rethwilm, Kongola, Gilbert, Horn Anne, Majinge Charles, August Stich, Horn, Anne, Bodem, Jochen, Mllewa, Mathias, Graeme B. Jacobs, Samuel Kalluvya, Carsten Scheller, Rethwilm Axel, Benedikt Weissbrich, Weissbrich, Benedikt   +57 more
core   +2 more sources

Detection of Hepatitis B Virus Drug Resistance Mutations by Pyrosequencing Method

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2018
Introduction: The development of drug resistance mutations to nucleos(t)ide analogues during long-term therapy for chronic hepatitis B virus (HBV) infection is a major problem that may lead to treatment failure.
Mehmet ÇİMENTEPE, Deniz YILDIRIM, Süheyla KÖMÜR, Buket ŞEFLEK, Deniz ÖZDOĞRU SAĞDIÇ, Fügen YARKIN   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source