Results 101 to 110 of about 8,234,457 (404)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Scientific Reports, 2022 The human mu rhythm has been suggested to represent an important function in information processing. Rodent homologue rhythms have been assumed though no study has investigated them from the cognitive aspect yet.
Diána Kostyalik +5 more
doaj +1 more source
Journal of Research in Pharmacy, 2023 The quality and efficacy of treatment in the healthcare industry have dramatically changed over the last century as a consequence of advancements in medical science, mass manufacturing of chemically synthesized pharmaceuticals, and technologies. However, due to the fact that natural treatments are more accessible but also less expensive than prescribed
openaire +3 more sources
Automated Detection of Systematic Off-label Drug Use in Free Text of Electronic Medical Records. [PDF]
, 2013 Off-label use of a drug occurs when it is used in a manner that deviates from its FDA label. Studies estimate that 21% of prescriptions are off-label, with only 27% of those uses supported by evidence of safety and efficacy.
Jung, Kenneth +2 more
core +2 more sources
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Drug Sale and Manufacture Arrests Reported in Alaska, 1986–2017 [PDF]
, 2018 Underlying data is available in both Excel and PDF format. (Download below.)This fact sheet presents data on drug sale and manufacture arrests reported by Alaska law enforcement agencies for the 32-year period 1986 to 2017.
Ervin, Benjamin
core
Towards a transparent, credible, evidence-based decision-making process of new drug listing on the Hong Kong Hospital Authority Drug Formulary: challenges and suggestions [PDF]
, 2017 The aim of this article is to describe the process, evaluation criteria, and possible outcomes of decision-making for new drugs listed in the Hong Kong Hospital Authority Drug Formulary in comparison to the health technology assessment (HTA) policy ...
Cheung, Bernard M.Y. +2 more
core +2 more sources
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Changing Course: A Review of the First Two Years of Drug Transfer Reform in Illinois [PDF]
, 2008 Provides an overview of data on automatic transfers of fifteen- and sixteen-year-olds charged with certain drug offenses to adult courts, of reform efforts to repeal the transfer law, and of the immediate impact on juvenile caseloads and public ...
Elizabeth Kooy
core
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source