Results 131 to 140 of about 8,234,457 (404)
Scientific ReportsWe present a rigorous validation strategy to evaluate the performance of Ultivue multiplex immunofluorescence panels. We have quantified the accuracy and precision of four different multiplex panels (three human and one mouse) in tumor specimens with ...
Sripad Ram +5 more
doaj +1 more source
BMJ Open, 2016 Objective Phase IV trials are often used to investigate drug safety after approval. However, little is known about the characteristics of contemporary phase IV clinical trials and whether these studies are of sufficient quality to advance medical ...
Xin-ji Zhang +5 more
semanticscholar +1 more source
Drug tolerability versus drug safety
Journal of Dermatological Treatment, 2023 Stuti Prajapati +2 more
openaire +3 more sources
Drug Possession Arrests Reported in Alaska, 1986–2017 [PDF]
, 2018 Underlying data is available in both Excel and PDF format. (Download below.)This fact sheet presents data on drug sale possession arrests reported by Alaska law enforcement agencies for the 32-year period 1986 to 2017. Overall, the drug possession arrest
Ervin, Benjamin
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What is the epidemiology of medication errors, error-related adverse events and risk factors for errors in adults managed in community care contexts? A systematic review of the international literature [PDF]
, 2018 © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.Objective To investigate the epidemiology of medication errors and ...
Aljadhey, Hisham +6 more
core +3 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Exploring BSEP Inhibition-Mediated Toxicity with a Mechanistic Model of Drug-Induced Liver Injury
Frontiers in Pharmacology, 2014 Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver.
Jeffrey L Woodhead +6 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
kurz und kn@pp news : Nr. 11 [engl. Fassung] [PDF]
, 2008 * Prize for excellent teaching * Drug prescription safety and renal failure * Prof. Gerlach on the Health Research Council of the German Ministry for Education and Research * Health in Old Age * DEGAM against IGeLn * A Meeting of
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source