Results 141 to 150 of about 8,989,140 (356)

Shedding Rights, Shredding Rights: A Critical Examination of Students\u27 Privacy Rights and the Special Needs Doctrine After Earls [PDF]

, 2002
On June 27, 2002, the United States Supreme Court held that all students participating in extracurricular activities in public schools may be subjected to random, suspicionless drug testing.
Penrose, Meg
core   +2 more sources

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Exploring BSEP Inhibition-Mediated Toxicity with a Mechanistic Model of Drug-Induced Liver Injury

Frontiers in Pharmacology, 2014
Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver.
Jeffrey L Woodhead, Kyunghee eYang, Scott Q Siler, Paul Brent Watkins, Kim L.R. Brouwer, Hugh A Barton, Brett A Howell   +6 more
doaj   +1 more source

Recent developments in using mechanistic cardiac modelling for drug safety evaluation

Drug Discovery Today, 2016
Highlights • Modelling and simulation can streamline decision making in drug safety testing.• Computational cardiac electrophysiology is a mature technology with a long heritage.• There are many challenges and opportunities in using in silico techniques ...
M. Davies, Ken Wang, Gary R. Mirams, A. Caruso, D. Noble, A. Walz, T. Lavé, F. Schuler, T. Singer, L. Polonchuk   +9 more
semanticscholar   +1 more source

Global Environmental Law: Food Safety & China [PDF]

, 2013
This article makes the case for food security law and policy as a component of global environmental law in recognition of the global economy, trade liberalization, and concerns for food safety and environmental harm. It further describes rule of law as a
Czarnezki, Jason J.
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Generation of cynomolgus monkey capsid-specific positive control cells for IFNγ ELISpot assays for adeno-associated gene therapy applications

Journal of Immunotoxicology
Cell-mediated immune (CMI) responses to adeno-associated virus (AAV) can lead to tissue damage and loss of therapeutic transgene expression. Identifying robust biomarkers and mechanisms of CMI can aid clinical practice and advancement of AAV gene ...
Sandra Casinghino, Karrie Tartaro, Jessica Anderson, Ravindra C. Kodihalli, Sophia G. Lee, Jessie Qian, Patricia A. Schneider, Richard Virgen-Slane, Laurence O. Whiteley, Thomas A. Lanz   +9 more
doaj   +1 more source

Overview of phase IV clinical trials for postmarket drug safety surveillance: a status report from the ClinicalTrials.gov registry

BMJ Open, 2016
Objective Phase IV trials are often used to investigate drug safety after approval. However, little is known about the characteristics of contemporary phase IV clinical trials and whether these studies are of sufficient quality to advance medical ...
Xin-ji Zhang, Yuan Zhang, X. Ye, Xiao-jing Guo, Tianyi Zhang, Jia He   +5 more
semanticscholar   +1 more source