Results 151 to 160 of about 835,419 (313)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Benchmarking porcine pancreatic ductal organoids for drug screening applications. [PDF]

EMBO Mol Med
Karampelias C, Yang K, Farkas FJ, Sterr M, Molina van Den Bosch M, Renner S, Fuß J, von Toerne C, Franzenburg S, Kin T, Wolf E, Kemter E, Lickert H.   +12 more
europepmc   +1 more source

How Phenotypic Screening Influenced Drug Discovery: Lessons from Five Years of Practice [PDF]

, 2017
Dorothea Haasen, Ulrich Schopfer, Christophe Antczak, Chantale T. Guy, Florian Fuchs, Paul M. Selzer   +5 more
openalex   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

A vascularized 3D bioengineered lung tumor model for anticancer drug screening. [PDF]

Cancer Cell Int
Wang M, Ye Y, Yuan R, Zheng X, Li X, Han Y, Guo L, Lei T, Wang X.   +8 more
europepmc   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Microfluidic Perfusable Pathological Vasculature for Atherosclerosis Drug Screening. [PDF]

Research (Wash D C)
Liu J, Zhu M, Bai N, Huang N, Zhang W, Yang Z, Wang Y.   +6 more
europepmc   +1 more source

Potential of FTIR-Spectroscopy for Drugs Screening against Helicobacter pylori [PDF]

, 2020
Pedro Sampaio, Cecília R. C. Calado
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Screening stabilisers for cyanoenone triterpenoid TX101 in rat plasma samples by simultaneous analysis of parent drug and the epoxidation product [PDF]

Lynn Tian, Qingguo Tian, Edward Tamer
openalex   +1 more source