Results 171 to 180 of about 1,604,042 (306)

Retraction Note: Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1/VE-cadherin pathway

Cell Death and Disease
Ting Xiao, Weilong Zhong, Jianmin Zhao, Baoxin Qian, Huijuan Liu, Shuang Chen, Kailiang Qiao, Yueyang Lei, Shumin Zong, Hongzhi Wang, Yuan Liang, Heng Zhang, Jing Meng, Honggang Zhou, Tao Sun, Yanrong Liu, Cheng Yang   +16 more
doaj   +1 more source

Predicted peptide scaffolds for drug screening in endometrial cancer organoids. [PDF]

Sci Rep
Zhang M, Wan Y, Li D.
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Benchmarking porcine pancreatic ductal organoids for drug screening applications. [PDF]

EMBO Mol Med
Karampelias C, Yang K, Farkas FJ, Sterr M, Molina van Den Bosch M, Renner S, Fuß J, von Toerne C, Franzenburg S, Kin T, Wolf E, Kemter E, Lickert H.   +12 more
europepmc   +1 more source

Antineoplastic Drug Screening [PDF]

JNCI Journal of the National Cancer Institute, 1992
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Development, Expansion, and Histological Characterization of Patient-Derived Liver Organoids for Drug Screening and Disease Modeling. [PDF]

Bio Protoc
De Siervi S, Mantovani S, Oliviero B, Mondelli MU, Di Noia M, Soldani C, Franceschini B, De Luca F, Maestri M, Corallo S, Lolicato M, Cannito S, Turato C.   +12 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Individualized drug screening in cholangiocarcinoma using organoid models and patient-derived tumor xenograft. [PDF]

BMC Cancer
Han P, Zhu L, Tong W, Liu S, Xu Y, Wang L, Wang T, Zhao T, Miao Y, Chi H, Cui T, Wang Z, Yang L, Zhang Y.   +13 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source