Results 11 to 20 of about 1,620,706 (306)

Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni [PDF]

, 2015
Schistosomiasis, one of the world's greatest neglected tropical diseases, is responsible for over 280,000 human deaths per annum. Praziquantel, developed in the 1970s, has high efficacy, excellent tolerability, few and transient side effects, simple ...
Altamura, Sergio, Bresciani, Alberto, Gennari, Nadia, GUIDI, ALESSANDRA, LALLI, CRISTIANA, Ruberti, Giovina   +5 more
core   +3 more sources

Ligand-based virtual screening using binary kernel discrimination [PDF]

, 2005
This paper discusses the use of a machine-learning technique called binary kernel discrimination (BKD) for virtual screening in drug- and pesticide-discovery programmes.
Beining Chen, Bender A, Bender A, Chido Mpanhanga, David J. Wilton, Harper G, Hert J, Holliday JD, Jérôme Hert, Klebe G, Peter Willett, Robert F. Harrison, Shemetulskis NE, Willett P, Wilton DJ   +14 more
core   +1 more source

IL6 supports long-term expansion of hepatocytes in vitro

Nature Communications, 2022
Hepatocytes are very difficult to expand in vitro. Here the authors discover that IL6 promotes long-term expansion (>30 passages) of primary mouse hepatocytes in vitro by converting the cells into hepatic progenitor cells, which maintain full capacity of
Ren Guo, Mengmeng Jiang, Gang Wang, Bing Li, Xiaohui Jia, Yan Ai, Shanshan Chen, Peilan Tang, Aijie Liu, Qianting Yuan, Xin Xie   +10 more
doaj   +1 more source

Identification of imidazo[4,5-c]pyridin-2-one derivatives as novel Src family kinase inhibitors against glioblastoma

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumour in the central nervous system (CNS). As the ideal targets for GBM treatment, Src family kinases (SFKs) have attracted much attention.
Lishun Zhang, Zichao Yang, Huiting Sang, Ying Jiang, Mingfeng Zhou, Chuan Huang, Chunhui Huang, Xiaoyun Wu, Tingting Zhang, Xingmei Zhang, Shanhe Wan, Jiajie Zhang   +11 more
doaj   +1 more source

Docking-based virtual screening of known drugs against murE of Mycobacterium tuberculosis towards repurposing for TB. [PDF]

, 2016
Repurposing has gained momentum globally and become an alternative avenue for drug discovery because of its better success rate, and reduced cost, time and issues related to safety than the conventional drug discovery process.
Brindha, Sridharan, Gnanadoss, John Joel, Sundaramurthi, Jagadish Chandrabose, Velmurugan, Devadasan, Vincent, Savariar   +4 more
core   +1 more source

Hypoglycemic effect of Camellia chrysantha extract on type 2 diabetic mice model

Bangladesh Journal of Pharmacology, 2017
The aim of this study was to investigate the hypoglycemic effect of Camellia chrysantha using type 2 diabetic mice model. The ethyl acetate/dichloromethane extract exhibited the most effective hypoglycemic effect.
Lai Wang, Debmalya Roy, Sen Sen Lin, Sheng Tao Yuan, Li Sun   +4 more
doaj   +1 more source

Estimating the cost-effectiveness of detecting cases of chronic hepatitis C infection on reception into prison [PDF]

, 2006
Background In England and Wales where less than 1% of the population are Injecting drug users (IDUs), 97% of HCV reports are attributed to injecting drug use. As over 60% of the IDU population will have been imprisoned by the age of 30 years, prison may
AJ Sutton, AJ Sutton, Andrew J Sutton, C Skipper, D Best, D de Angelis, EG Schlicting, GE Macalino, Health Protection Agency Centre for Infections, HM Treasury, HP Agency, JA Horne, K Roy, K Stein, L Curtis, L Weissing, LB Seeff, M Frischer, O Noel Gill, P Leal, P Mortimer, P Reuter, S Darke, W John Edmunds, W Limburg   +24 more
core   +5 more sources

SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model

Frontiers in Pharmacology, 2017
Intrahepatic cholestasis is a kind of clinical syndrome along with hepatotoxicity which caused by intrahepatic and systemic accumulations of bile acid. There are several crucial generating factors of the pathogenesis of cholestasis, such as inflammation,
Linxi Yu, Xiaoxin Liu, Zihang Yuan, Xiaojiaoyang Li, Hang Yang, Ziqiao Yuan, Lixin Sun, Luyong Zhang, Luyong Zhang, Luyong Zhang, Zhengzhou Jiang, Zhengzhou Jiang   +11 more
doaj   +1 more source

Urine Screening for Opiod and Illicit Drugs in the Total Joint Arthroplasty Population [PDF]

, 2020
Introduction. Recent studies have shown an increase in post-operative orthopaedic complications associated with pre-operative opioid use. It is, therefore, important to know if patients use opioids before scheduled surgery.
Bhargava, Tarun, Messamore, William, Schmanke, Ken, Trent, Jesse, Vopat, Matthew, Yang, Shang-You, Zackula, Rosey   +6 more
core   +2 more sources

Brevinin-2GHk, a Peptide Derived from the Skin of Fejervarya limnocharis, Inhibits Zika Virus Infection by Disrupting Viral Integrity

Viruses, 2021
Several years have passed since the Zika virus (ZIKV) pandemic reoccurred in 2015–2016. However, there is still a lack of proved protective vaccines or effective drugs against ZIKV.
Weichen Xiong, Jingyan Li, Yifei Feng, Jinwei Chai, Jiena Wu, Yunrui Hu, Maolin Tian, Wancheng Lu, Xueqing Xu, Min Zou   +9 more
doaj   +1 more source