Results 21 to 30 of about 1,620,706 (306)
In Vitro Screening Test Using Leishmania Promastigotes Stably Expressing mCherry Protein [PDF]
, 2014 Transgenic Leishmania major and Leishmania donovani axenic promastigotes constitutively expressing mCherry were used for in vitro antileishmanial drug screening. This method requires minimal sample manipulation and can be easily adapted to automatic drug
Miguel A. Morales, Vacchina, Paola
core +2 more sources
In Silico screening of nonsteroidal anti-inflammatory drugs and their combined action on Prostaglandin H Synthase-1 [PDF]
, 2010 The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective ...
Demin, Oleg +5 more
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An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z [PDF]
, 2019 The classical form of α1-antitrypsin deficiency (ATD) is characterized by intracellular accumulation of the misfolded variant α1-antitrypsin Z (ATZ) and severe liver disease in some of the affected individuals.
Andrew S. Chu (6256490) +12 more
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Molecules, 2015 Deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, was isolated from Anthriscus sylvestris, and a few studies have reported its anti-cancer effect. However, the in vivo antitumor efficacy of DPT is currently indeterminate.
Yu-Rong Wang +6 more
doaj +1 more source
Foods, 2022 Hyperuricemia (HUA), characterized by abnormal serum uric acid (UA) levels, is recognized as an important risk factor for hyperuricemic nephropathy (HN), which is strongly linked to gut microbiota.
Yongmei Li +8 more
doaj +1 more source
Nature Communications, 2021 Inhibitor of Differentiation 1 (ID1) is an oncogene for colorectal cancer. Here, the authors show a complex interplay between nuclear receptor Nur77 and Transforming Growth Factor-β (TGFβ) to regulate ID1 expression at both transcriptional and post ...
Boning Niu +9 more
doaj +1 more source
Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition [PDF]
, 2018 The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile.
Chen, Yuan +5 more
core +1 more source
Apoptosis chip for drug screening [PDF]
, 2007 This thesis described the process of the development towards a microfluidic platform to perform apoptosis studies on chip in real-time at a single-cell ...
Wolbers, Floor
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
The Influence of CTAB-Capped Seeds and Their Aging Time on the Morphologies of Silver Nanoparticles
Nanoscale Research Letters, 2019 Contrast to the polydisperse nanorods formed by common seed-mediated growth method without the presence of cetyltrimethylammonium bromide (CTAB) in seed solution, we successfully obtained silver nanoparticles with different morphologies in the same ...
Wenxiu Jin +6 more
doaj +1 more source