Results 31 to 40 of about 3,703,394 (160)

Anticipated regret to increase uptake of colorectal cancer screening (ARTICS):a randomised controlled trial [PDF]

, 2015
Screening is important for early detection of colorectal cancer. Our aim was to determine whether a simple anticipated regret (AR) intervention could increase uptake of colorectal cancer screening. A randomised controlled trial of a simple, questionnaire-
Brownlee, Linda A., Steele, Robert J. C., O'Carroll, Ronan E., Steele, Robert, Chambers, Julie A., Chambers, Julie, Brownlee, Linda, Libby, Gillian, Steele, Robert J.C., O'Carroll, Ronan   +9 more
core   +1 more source

Prevalence and risk factors of syphilis infection among drug addicts [PDF]

, 2005
Background: Recent epidemiological data show an increased trend of official estimates for syphilis infection in the general population. Many of the infected cases remain undetected leaving an underestimation of the true prevalence of syphilis in the ...
Scherbaum, Norbert, Martin Reker, Reker, M, Baune, B., Norbert Scherbaum, Gerhard Reymann, Kuhlmann, T., Reymann, Gerhard, Bernhard T Baune, Reymann Gerhard, Reymann, G., Thomas Kuhlmann, Kuhlmann, T, Kuhlmann Thomas, Mikolajczyk Rafael, Kuhlmann, Thomas, Scherbaum, N., Reker Martin, Rafael Mikolajczyk, Baune Bernhard T, Mikolajczyk, R., Reker, M., Scherbaum Norbert, Scherbaum, N, Reker, Martin, Sherbaum, Norbert, Mikolajczyk, R, Mikolajczyk, Rafael T., Baune, BT, Reymann, G, Mikolajczyk, Rafael, Baune, Bernhard T.   +31 more
core   +2 more sources

Brazilian Green Propolis Extract Synergizes with Protoporphyrin IX-mediated Photodynamic Therapy via Enhancement of Intracellular Accumulation of Protoporphyrin IX and Attenuation of NF-κB and COX-2

Molecules, 2017
Brazilian green propolis (BGP) is noted for its impressive antitumor effects and has been used as a folk medicine in various cultures for many years. It has been demonstrated that BGP could enhance the cytotoxic effect of cytostatic drugs on tumor cells.
Cheng-Cheng Wang, Yu-Xuan Wang, Nian-Qin Yu, Die Hu, Xiao-Yan Wang, Xing-Guang Chen, You-Wei Liao, Jing Yao, Hao Wang, Ling He, Liang Wu   +10 more
doaj   +1 more source

Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1 axis ameliorates hepatosteatosis

Cell Death and Disease, 2023
Converting lipid disturbances in response to energy oversupply into healthy lipid homeostasis is a promising therapy to alleviate hepatosteatosis. Our clinical studies found that a further elevation of triglyceride (TG) in obese patients with the body ...
Yulian Chen, Huanguo Jiang, Zhikun Zhan, Jindi Lu, Tanwei Gu, Ping Yu, Weimin Liang, Xi Zhang, Shuwen Liu, Huichang Bi, Shilong Zhong, Lan Tang   +11 more
doaj   +1 more source

Nanobodies targeting the Epstein-Barr virus EBNA1 DNA binding domain inhibit tumor growth

Journal of Nanobiotechnology
Background The Epstein-Barr virus (EBV)-encoded nuclear antigen 1 (EBNA1) is a pivotal oncoprotein essential for maintaining viral latency, promoting cellular immortalization, and driving tumorigenesis in EBV-associated malignancies.
Fang Wu, Yuzhe Wu, Yongyue Han, Long Ma, Yuanwei Huang, Chiwei Peng, Jun Liu, Peixuan Gao, Wei Xu   +8 more
doaj   +1 more source

Antihyperuricemic effect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidase activity and urate transporter 1 expression in mice

Acta Pharmaceutica Sinica B, 2018
A mangiferin aglycon derivative J99745 has been identified as a potent xanthine oxidase (XOD) inhibitor by previous in vitro study. This study aimed to evaluate the hypouricemic effects of J99745 in experimental hyperuricemia mice, and explore the ...
Zhizhen Qin, Shoubao Wang, Yihuang Lin, Ying Zhao, Shengqian Yang, Junke Song, Tao Xie, Jinlong Tian, Song Wu, Guanhua Du   +9 more
doaj   +1 more source

Anti-Cancer Drug Screening with Microfluidic Technology

, 2021
The up-and-coming microfluidic technology is the most promising platform for designing anti-cancer drugs and new point-of-care diagnostics. Compared to conventional drug screening methods based on Petri dishes and animal studies, drug delivery in ...
Navid Kashaninejad, Milad Rismanian, Jamaati, H, Kashaninejad, N, Monjezi, M, Mojdeh Monjezi, Rismanian, M, Hamidreza Jamaati   +7 more
core   +1 more source

PPARα regulates YAP protein levels and activity by affecting its ubiquitination modification

BMC Biology
Background Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in liver physiological and pathological processes. Yes-associated protein (YAP) is a key effector in regulating cell growth and organ size.
Wenhong Zhou, Shuaishuai Zhang, Yao Chen, Ziqi Chen, Guofang Bi, Manlan Guo, Xiaowen Jiang, Xiao Yang, Jianhong Fang, Linhu Ye, Shicheng Fan, Huichang Bi   +11 more
doaj   +1 more source

Enhancing Multifunctional Drug Screening via Artificial Intelligence [PDF]

Computational drug screening is of fundamental importance in early-stage drug discovery. The current computational methods predict compound affinities to their targets based on docking or pharmacophore (PH4) hypotheses.
Dong, Junlin, Hu, Zhenquan, Lu, Tianle, Wang, Shiyu, Zhan, Wenjin, Wu, Chenyang, Yuan, Shuguang, Wang, Bing, Vogel, Horst, Xu, Marc   +9 more
core   +1 more source

Recommendations for a colorectal cancer screening programme in Ireland [PDF]

, 2008
In April 2007, the National Cancer Screening Service Board established an expert advisory group to study the medical and scientific evidence concerning screening for colorectal cancer and to make recommendations to the Board about the potential benefits ...
NCSS Expert Advisory Group on Colorectal Cancer Screening
core   +1 more source