Results 31 to 40 of about 942,716 (313)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning [PDF]

, 2015
Neglected tropical diseases cause significant morbidity and mortality and are a source of poverty in endemic countries. Only a few drugs are available to treat diseases such as leishmaniasis, Chagas' disease, human African trypanosomiasis and malaria ...
Leela Pavan Tadoori, Leela Pavan Tadoori (782938), Marcel Kaiser, Pascal Mäser, Jean-Robert Ioset (115415), Tadoori, Leela Pavan, Marcel Kaiser (41510), Ioset, Jean-Robert, Mäser, Pascal, Kaiser, Marcel, Brun, Reto, Pascal Mäser (87895), Jean-Robert Ioset, Reto Brun, Reto Brun (41511)   +14 more
core   +1 more source

Anthelmintic drug discovery: target identification, screening methods and the role of open science [PDF]

, 2020
Helminths, including cestodes, nematodes and trematodes, are a huge global health burden, infecting hundreds of millions of people. In many cases, existing drugs such as benzimidazoles, diethylcarbamazine, ivermectin and praziquantel are insufficiently ...
Else, K.J., Bataille, C.J.R., Forman, R., Wynne, G.M., Partridge, F.A., Nick, M., Sattelle, D.B., Russell, A.J.   +7 more
core   +1 more source

The Influence of CTAB-Capped Seeds and Their Aging Time on the Morphologies of Silver Nanoparticles

Nanoscale Research Letters, 2019
Contrast to the polydisperse nanorods formed by common seed-mediated growth method without the presence of cetyltrimethylammonium bromide (CTAB) in seed solution, we successfully obtained silver nanoparticles with different morphologies in the same ...
Wenxiu Jin, Guorun Liang, Yuanzhi Zhong, Yongcong Yuan, Zhichao Jian, Zhixiong Wu, Wanzhong Zhang   +6 more
doaj   +1 more source

Effects of sulfometuron-methyl on zebrafish at early developmental stages

Ecotoxicology and Environmental Safety, 2021
Sulfometuron methyl (SM) is a widely used herbicide and thus leading to accumulation in the environment. The toxicity assessments of SM in model organisms are currently rare.
Wei Yuan, Zhaopeng Xu, You Wei, Wuting Lu, Kun Jia, Jing Guo, Yunlong Meng, Yuyang Peng, Zhanfeng Wu, Zulin Zhu, Fei Ma, Fenghua Wei, Guiyou Tian, Zhou Liu, Qiang Luo, Jinze Ma, Hao Zhang, Wenjin Liu, Huiqiang Lu   +18 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Estimating the cost-effectiveness of detecting cases of chronic hepatitis C infection on reception into prison [PDF]

, 2006
Background In England and Wales where less than 1% of the population are Injecting drug users (IDUs), 97% of HCV reports are attributed to injecting drug use. As over 60% of the IDU population will have been imprisoned by the age of 30 years, prison may
Sutton, AJ, Edmunds, W. John, Edmunds, WJ, Gill, ON, Andrew J Sutton, O Noel Gill, Gill, O. N., Edmunds W John, Sutton Andrew J, Gill, O Noel, Sutton, Andrew J, Edmunds, W John, Sutton, A. J., W John Edmunds, Gill O Noel   +14 more
core   +1 more source

Kinetically and thermodynamically controlled one-pot growth of gold nanoshells with NIR-II absorption for multimodal imaging-guided photothermal therapy

Journal of Nanobiotechnology, 2023
Since the successful clinical trial of AuroShell for photothermal therapy, there is currently intense interest in developing gold-based core-shell structures with near-infrared (NIR) absorption ranging from NIR-I (650–900 nm) to NIR-II (900–1700 nm ...
Ming Chen, Xiao-Tong Chen, Lian-Ying Zhang, Wei Meng, Yong-Jian Chen, Ying-Shan Zhang, Zhi-Cong Chen, Hui-Min Wang, Chun-Mei Luo, Xiu-Dong Shi, Wen-Hua Zhang, Mao-Sheng Wang, Jin-Xiang Chen   +12 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source