Results 51 to 60 of about 3,703,394 (160)

PTBP1 inhibition reprograms myogenesis to rescue impaired muscle regeneration in mdx mice through correcting E2A splicing

Nature Communications
Duchenne muscular dystrophy, caused by mutations in the DMD gene encoding dystrophin, is a severe progressive muscle-wasting disorder characterized by impaired muscle regeneration.
Shusheng Fan, Xiaoyun Liu, Qian Pan, Haowei Tong, Qiaoqiao Gui, Guangyao Guo, Huitao Hong, Wanting Hu, Xiaofei Huang, Lei Zhao, Xihua Li, Qinwei Yu, Luyong Zhang, Zhenzhou Jiang   +13 more
doaj   +1 more source

Inhibition of Kv1.3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation

Pharmacological Research
Macrophages play crucial roles in regulating both homeostatic and inflammatory responses, with classical activated (M1) and alternatively activated (M2) subsets defined by the surrounding micro-environment.
Yanshan Chen, Yuanxing Zhi, Hailin Zhong, Liang Ma, Xinpei Gu, Yijing Cai, Jingjing Huang, Xin Yi, Xiaoyan Wu, Ken Kin Lam Yung, Pingzheng Zhou   +10 more
doaj   +1 more source

PXR activation ameliorates hyperuricemic nephropathy via NRF2 signaling

Pharmacological Research
Long-term hyperuricemia (HUA) constitutes a major determinant of HUA-induced nephropathy (HN), yet current uricosuric drugs often exhibit limited efficacy and may pose a risk of kidney damage.
Ting Wu, Lu Li, Yongjun Chen, Wenjie Ye, Zitao Guo, Fengting Liang, Wenhong Zhou, Zichao Yang, Fengxin Zheng, Hui Liao, Guofang Bi, Xiao Yang, Shicheng Fan, Jian-Hong Fang, Jianxin Pang, Huichang Bi   +15 more
doaj   +1 more source

Tumor-associated Adipose Tissue Microenvironment Supports Tumor Progression

Zhongliu Fangzhi Yanjiu, 2018
The peritumoral adipose tissue makes an intricate crosstalk with tumor cells and also plays a key role in tumor proliferation, invasion and metastasis because it provides hormones, adipokines and fatty acids to tumor cells.
LI Sijing, WEI Xiaohui, HE Jinyong, YUAN Shengtao, SUN Li   +4 more
doaj   +1 more source

Bisarylureas Based on 1H-Pyrazolo[3,4-d]pyrimidine Scaffold as Novel Pan-RAF Inhibitors with Potent Anti-Proliferative Activities: Structure-Based Design, Synthesis, Biological Evaluation and Molecular Modelling Studies

Molecules, 2017
RAF (Ras activating factor) kinases are important and attractive targets for cancer therapy. With the aim of discovering RAF inhibitors that bind to DFG-out inactive conformation created by the movement of Asp-Phe-Gly (DFG), we conducted structure-based ...
Yu Fu, Yuanyuan Wang, Shanhe Wan, Zhonghuang Li, Guangfa Wang, Jiajie Zhang, Xiaoyun Wu   +6 more
doaj   +1 more source

Irish Cervical Screening Programme annual report 2005 [PDF]

, 2006
Irish Cervical Screening Programme ...
Irish Cervical Screening Programme (ICSP)
core  

Development of VP30-targeted nanoparticles using DPS4 fusion peptides for the inhibition of Ebola virus

Journal of Nanobiotechnology
Multiple outbreaks of Ebola virus in West Africa have posed significant threats to global public health owing to its high pathogenicity and fatality rates.
Fang Wu, Yuanwei Huang, Rui Li, Peixuan Gao, Pinpin Lv, Guanxian Wu, Yanhong Ma, Qiang Ding, Jin Zhong, Jiyan Su, Wei Xu   +10 more
doaj   +1 more source

Effect of adoptive transfer or depletion of regulatory T cells on triptolide-induced liver injury

Frontiers in Pharmacology, 2016
ObjectiveThe aim of this study is to clarify the role of regulatory T cell (Treg) in triptolide (TP)-induced hepatotoxicity. MethodsFemale C57BL/6 mice received either adoptive transfer of Tregs or depletion of Tregs, then underwent TP administration and
Xinzhi eWang, Lixin eSun, Luyong eZhang, Zhenzhou eJiang   +3 more
doaj   +1 more source

HLA-B*5701 screening for hypersensitivity to Abacavir [PDF]

, 2008
Background Hypersensitivity reaction to abacavir is strongly associated with the presence of the HLA-B*5701 allele. This study was designed to establish the effectiveness of prospective HLA-B*5701 screening to prevent the hypersensitivity reaction to ...
Jagel-Guedes, E., Kozyrev, O., Phillips, E., Fitch, N., Thorborn, D., Molina, J-M, Hughes, A., Cid, J.F., Rugina, S., Nolan, D., Carosi, G., Hay, P., Ryan, S., Tomazic, J., Hughes, S., Benbow, A., Mallal, S., Workman, C.   +17 more
core  

Estimating the cost-effectiveness of detecting cases of chronic hepatitis C infection on reception into prison [PDF]

, 2006
Background In England and Wales where less than 1% of the population are Injecting drug users (IDUs), 97% of HCV reports are attributed to injecting drug use. As over 60% of the IDU population will have been imprisoned by the age of 30 years, prison may
Sutton, AJ, Edmunds, W. John, Edmunds, WJ, Gill, ON, Andrew J Sutton, O Noel Gill, Gill, O. N., Edmunds W John, Sutton Andrew J, Gill, O Noel, Sutton, Andrew J, Edmunds, W John, Sutton, A. J., W John Edmunds, Gill O Noel   +14 more
core   +2 more sources