Results 71 to 80 of about 942,716 (313)

Piperlongumine Inhibits Akt Phosphorylation to Reverse Resistance to Cisplatin in Human Non-Small Cell Lung Cancer Cells via ROS Regulation

Frontiers in Pharmacology, 2019
Resistance is a major concern when administering chemotherapy to patients with non-small cell lung cancer (NSCLC). Chemosensitizer are agents that can reverse resistance to chemotherapeutic drugs, thereby enhancing the chemosensitivity of tumor cells ...
Chao Zhang, Chao Zhang, Lian-Jun He, Yi-Bao Zhu, Qing-Zhu Fan, Dong-Dong Miao, Sheng-Peng Zhang, Wen-Ying Zhao, Xiao-Ping Liu, Xiao-Ping Liu   +9 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cepharanthine inhibits influenza A virus replication by impairing viral polymerase activity and regulating influenza-induced immune response

Phytomedicine Plus
Background: Cepharanthine (CEP), a natural bis-benzylisoquinoline alkaloid extracted from the plant Stephania cephalantha Hayata, has been widely used to treat several acute and chronic diseases. However, its antiviral potential against influenza A virus
Yinyan Li, Huiting Sang, Qinxian Mo, Linrui Jiang, Zhixuan Chen, Jinlong Liang, Chunyu Zhang, Zhengyin Zhang, Chenglai Xia, Jie Yang   +9 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Indexed plasma drug concentrations for drug adherence screening in hypertensive patients.

, 2018
AIM: Due to its high sensitivity, qualitative plasma drug screening by liquid chromatography/tandem mass spectrometry may not be able to distinguish same-day drug intake from drug use on preceding days and cause misclassifications of drug adherence in ...
Haschke, Manuel Martin, F.A. Sandbaumhüter, J.M. Bohlender, Sandbaumhüter, Friederike Andrea, M. Haschke, Vogt, Bruno, Bohlender, Jürgen, B. Vogt   +7 more
core   +1 more source

Screening and brief interventions for hazardous alcohol use in accident and emergency departments: a randomised controlled trial protocol [PDF]

, 2009
There is a wealth of evidence regarding the detrimental impact of excessive alcohol consumption on the physical, psychological and social health of the population.
Myles, J., Deluca Paolo, Perryman, K., Bland, M., Drummond, Colin, Perryman Katherine, Shepherd, Jonathan, Gilvarry Eilish, Newbury-Birch, Dorothy, Deluca, P., Miles, Judy, Mike Crawford, Cassidy, P., Crawford, M., Phillips, T., Shenker Don, Godfrey, Christine, Deluca, Paolo; id_orcid, Myles, Judy, Jonathan Shepherd, Parrott Steve, Coulton, S., Christine Godfrey, Bland, Martin, Shepherd Jonathan, Perryman, Katherine, Phillips, Tom, Newbury-Birch Dorothy, Oyefeso Adenekan, Eileen Kaner, Oyefeso, A., Shenker, D., Myles Judy, Adenekan Oyefeso, Shepherd, Jonathan Paul, Judy Myles, Steve Parrott, Don Shenker, Heather, Nick, Oyefeso, Adenekan, Coulton, Simon, Deluca, Paolo, Parrott, Steve, Katherine Perryman, Colin Drummond, Coulton Simon, Kaner Eileen, Godfrey, C., Newbury-Birch, D., Newbury-Birch, Dorothy; id_orcid, Drummond, Colin; id_orcid, Paolo Deluca, Nick Heather, Cassidy, Paul, Phillips Tom, Tom Phillips, Godfrey Christine, Dorothy Newbury-Birch, Crawford Mike, Bland Martin, Gilvarry, Eilish, Kaner, Eileen, Kaner, E., Parrott, S., Cassidy Paul, Drummond, C., Heather, N., Simon Coulton, Shenker, Don, Martin Bland, Crawford, Mike, Philips, Tom, Eilish Gilvarry, Gilvarry, E., Drummond Colin, Heather Nick, Paul Cassidy   +76 more
core   +1 more source

Cilnidipine exerts antiviral effects in vitro and in vivo by inhibiting the internalization and fusion of influenza A virus

BMC Medicine
Background Influenza A virus (IAV) is a major cause of seasonal and global pandemics, posing serious health risks. Repositioning approved drugs offers an efficient antiviral strategy, particularly as calcium (Ca2⁺) is crucial for IAV infection, making ...
Yinyan Li, Sizu Yang, Feng Jiang, Siqi Luo, Jinlong Liang, Linrui Jiang, Zhixuan Chen, Xin Chen, Jie Yang   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Enhancing Multifunctional Drug Screening via Artificial Intelligence

Computational drug screening is of fundamental importance in early-stage drug discovery. The current computational methods predict compound affinities to their targets based on docking or pharmacophore (PH4) hypotheses.
Dong, Junlin, Hu, Zhenquan, Lu, Tianle, Wang, Shiyu, Zhan, Wenjin, Wu, Chenyang, Yuan, Shuguang, Wang, Bing, Vogel, Horst, Xu, Marc   +9 more
core   +1 more source

A screening method for vasodilator drugs

Journal of Pharmacy and Pharmacology, 1969
Abstract The use of the isolated perfused central artery of the rabbit ear for screening vasodilator drugs is described. The effects of these drugs are shown by reduction of vasoconstrictor responses to intermittent sympathetic stimulation or to injections of noradrenaline or histamine or by reduction of vascular spasms produced by ...
W S, Gay, M J, Rand, P, Ross
openaire   +2 more sources