Results 61 to 70 of about 3,703,394 (160)

The application of the fragment-based screening approach to RmlA protein and PA1645 structure [PDF]

open access: yes, 2014
P. aerguinosa is a serious human bacterial pathogen. This thesis describes attempts to use structural biology to identify new starting points for drugs against P.
Boulkeroua, Wassila Abdelli
core   +2 more sources

Codonopsis tangshen Oliv. Amelioration Effect on Diabetic Kidney Disease Rats Induced by High Fat Diet Feeding Combined with Streptozotocin

open access: yesNatural Products and Bioprospecting, 2018
Diabetic kidney disease (DKD) is the most serious microvascular complication during the development of diabetes with the characterizations of glomerular basement membrane thickening, mesangial expansion, and glomerular sclerosis, eventually leading to ...
Xian-Yuan Lu   +8 more
doaj   +1 more source

Evaluation of the Peer Support Program (Student Drug Prevention) 1986-1987

open access: yes, 2019
The Peer Support program is a school based program funded by the National Campaign Against Drug Abuse (NCADA) as a drug prevention strategy. Prior to the existence of the NCADA the program was funded through the NSW Drug and Alcohol Authority.
Directorate of the Drug Offensive
core   +1 more source

Investigating the CYP2E1 Potential Role in the Mechanisms Behind INH/LPS-Induced Hepatotoxicity

open access: yesFrontiers in Pharmacology, 2018
Tuberculosis (TB) is one of the oldest infectious diseases that affected humankind and remains one of the world’s deadliest communicable diseases that could be considered as global emergency, but the discovery and development of isoniazid (INH) in the ...
Hozeifa M. Hassan   +10 more
doaj   +1 more source

Microfluidic-based Drug Screening at Cellular and Organism Level

open access: yes, 2008
High content screening (HCS) and high throuhtput screening (HTS) are important trends for drug screening in ..
林炳承, 秦建华
core  

High content screening in neurodegenerative diseases [PDF]

open access: yes, 2012
The functional annotation of genomes, construction of molecular networks and novel drug target identification, are important challenges that need to be addressed as a matter of great urgency.
van Kesteren, R.E.   +3 more
core   +3 more sources

National Cancer Screening Service Annual Financial Statements 2007 [PDF]

open access: yes, 2008
Audited financial statements of the National Cancer Screening Service Board for the year ended 31 December ...
National Cancer Screening Service
core   +1 more source

In situ detection of piRNA‐651 in exosomes and cells for cancer diagnosis by a new gold nanoparticle nucleic acid probe

open access: yesInterdisciplinary Medicine
Increasing studies have demonstrated that PIWI‐interacting RNAs (piRNAs) in circulating exosomes can serve as novel molecular biomarkers for tumor liquid biopsy. However, methods for in situ detection of piRNAs encased in exosomes are limited.
Qin‐Xin Gao   +6 more
doaj   +1 more source

A novel ursodeoxycholic acid derivative exhibits broad-spectrum antiviral activity against influenza A virus and coronaviruses by multiphasic disruption of the viral life cycle

open access: yesAntimicrobial Agents and Chemotherapy
Seasonal influenza virus and human coronaviruses (HCoVs) represent persistent threats to global public health, with current antiviral agents limited by narrow-spectrum activity and the emergence of drug resistance.
Zheng Peng   +6 more
doaj   +1 more source

Structure‐based design of antibodies targeting the EBNA1 DNA‐binding domain to block Epstein–Barr virus latent infection and tumor growth

open access: yesMedComm
The Epstein–Barr virus (EBV) nuclear antigen 1 (EBNA1) is critically involved in maintaining episomes during latent infection and promoting tumorigenesis.
Yongyue Han   +8 more
doaj   +1 more source

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