Results 81 to 90 of about 942,716 (313)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Parabacteroides distasonis promotes liver regeneration by increasing β-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals

Acta Pharmaceutica Sinica B
The liver regenerative capacity is crucial for patients with end-stage liver disease following partial hepatectomy (PHx). The specific bacteria and mechanisms regulating liver regeneration post-PHx remain unclear.
Manlan Guo, Xiaowen Jiang, Hui Ouyang, Xianglong Zhang, Shuaishuai Zhang, Peng Wang, Guofang Bi, Ting Wu, Wenhong Zhou, Fengting Liang, Xiao Yang, Shicheng Fan, Jian-hong Fang, Peng Chen, Huichang Bi   +14 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Multitarget Virtual Screening for Drug Repurposing in COVID19

, 2020
Therapeutic or preventive research for coronavirus SARS-CoV2 is an extremely active topic of research since its outbreak in January 2020. In this paper we report the results from a virtual drug screening analysis that, to the best of our knowledge, is ...
carlos oscar, Sorzano, rafael, leon, Jose Maria, Carazo, Enrique, Crisman   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Inhibition of Kv1.3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation

Pharmacological Research
Macrophages play crucial roles in regulating both homeostatic and inflammatory responses, with classical activated (M1) and alternatively activated (M2) subsets defined by the surrounding micro-environment.
Yanshan Chen, Yuanxing Zhi, Hailin Zhong, Liang Ma, Xinpei Gu, Yijing Cai, Jingjing Huang, Xin Yi, Xiaoyan Wu, Ken Kin Lam Yung, Pingzheng Zhou   +10 more
doaj   +1 more source

Effect of adoptive transfer or depletion of regulatory T cells on triptolide-induced liver injury

Frontiers in Pharmacology, 2016
ObjectiveThe aim of this study is to clarify the role of regulatory T cell (Treg) in triptolide (TP)-induced hepatotoxicity. MethodsFemale C57BL/6 mice received either adoptive transfer of Tregs or depletion of Tregs, then underwent TP administration and
Xinzhi eWang, Lixin eSun, Luyong eZhang, Zhenzhou eJiang   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Microfluidic-based Drug Screening at Cellular and Organism Level

, 2008
High content screening (HCS) and high throuhtput screening (HTS) are important trends for drug screening in ..
林炳承, 秦建华
core  

PTBP1 inhibition reprograms myogenesis to rescue impaired muscle regeneration in mdx mice through correcting E2A splicing

Nature Communications
Duchenne muscular dystrophy, caused by mutations in the DMD gene encoding dystrophin, is a severe progressive muscle-wasting disorder characterized by impaired muscle regeneration.
Shusheng Fan, Xiaoyun Liu, Qian Pan, Haowei Tong, Qiaoqiao Gui, Guangyao Guo, Huitao Hong, Wanting Hu, Xiaofei Huang, Lei Zhao, Xihua Li, Qinwei Yu, Luyong Zhang, Zhenzhou Jiang   +13 more
doaj   +1 more source