Results 91 to 100 of about 942,716 (313)

PXR activation ameliorates hyperuricemic nephropathy via NRF2 signaling

Pharmacological Research
Long-term hyperuricemia (HUA) constitutes a major determinant of HUA-induced nephropathy (HN), yet current uricosuric drugs often exhibit limited efficacy and may pose a risk of kidney damage.
Ting Wu, Lu Li, Yongjun Chen, Wenjie Ye, Zitao Guo, Fengting Liang, Wenhong Zhou, Zichao Yang, Fengxin Zheng, Hui Liao, Guofang Bi, Xiao Yang, Shicheng Fan, Jian-Hong Fang, Jianxin Pang, Huichang Bi   +15 more
doaj   +1 more source

Tumor-associated Adipose Tissue Microenvironment Supports Tumor Progression

Zhongliu Fangzhi Yanjiu, 2018
The peritumoral adipose tissue makes an intricate crosstalk with tumor cells and also plays a key role in tumor proliferation, invasion and metastasis because it provides hormones, adipokines and fatty acids to tumor cells.
LI Sijing, WEI Xiaohui, HE Jinyong, YUAN Shengtao, SUN Li   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Screening for alcohol and drug use disorders among adults in primary care: a review

, 2012
Daniel J Pilowsky1, Li-Tzy Wu21Departments of Epidemiology and Psychiatry, Columbia University, and the New York State Psychiatric Institute, New York City, NY, 2Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University ...
Pilowsky, Daniel J, Wu, Li-Tzy, Wu LT, Pilowsky DJ   +3 more
core   +1 more source

Supercomputer-aided Drug Repositioning at Scale: Virtual Screening for SARS-CoV-2 Protease Inhibitor

, 2020
Coronavirus diseases (COVID-19) outbreak has been labelled a pandemic. For the prioritization of treatments to cope with COVID-19, it is important to conduct rapid high-throughput screening of chemical compounds to repurposing the approved drugs, such ...
Jung Woo, Park, Hyojung, Paik, Junwon, Yoon, Sangjae, Seo, Soonwook, Hwang, Dosik, An   +5 more
core   +1 more source

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]

, 2015
Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Barroso, Vanessa, Drewry, David H., Kessler, Albane, Pilar Manzano, M., Cotillo, Ignacio, Roquero, Irene, Alonso-Padilla, Julio, Bardera, Ana I., Navarro, Miguel, Manzano, Pilar, Brown, James R., Sherstnev, Alexander, Alvarez, Emilio, Rodríguez López, Ana, Fiandor, Jose M., Julio Martin, J., Dios-Antón, Francisco de, Kumar, Vinod, Peña, Imanol, Martin, José Julio, Gray, David W., Gray, David W.; id_orcid, Rodriguez, Ana, Navarro, M., Cantizani, Juan, de Dios-Anton, Francisco, Colmenarejo, Gonzalo   +26 more
core   +1 more source

Facilitating Drug Discovery in Breast Cancer by Virtually Screening Patients Using In Vitro Drug Response Modeling

, 2021
(1) Background: Drug imputation methods often aim to translate in vitro drug response to in vivo drug efficacy predictions. While commonly used in retrospective analyses, our aim is to investigate the use of drug prediction methods for the generation of ...
Gladys Morrison, Geoffrey L. Greene, Alexander Ling, R. Stephanie Huang, Robert F. Gruener, Paul Geeleher, Ya-Fang Chang   +6 more
core   +1 more source

Bisarylureas Based on 1H-Pyrazolo[3,4-d]pyrimidine Scaffold as Novel Pan-RAF Inhibitors with Potent Anti-Proliferative Activities: Structure-Based Design, Synthesis, Biological Evaluation and Molecular Modelling Studies

Molecules, 2017
RAF (Ras activating factor) kinases are important and attractive targets for cancer therapy. With the aim of discovering RAF inhibitors that bind to DFG-out inactive conformation created by the movement of Asp-Phe-Gly (DFG), we conducted structure-based ...
Yu Fu, Yuanyuan Wang, Shanhe Wan, Zhonghuang Li, Guangfa Wang, Jiajie Zhang, Xiaoyun Wu   +6 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

"In vitro" models of the blood-brain barrier : applications and evaluation of a new human immortalized brain capillary endothelial cell line [PDF]

, 2006
An optimal in vitro permeability screening model for the evaluation of BBB drug permeability accounts for active and passive transport processes, as well as for nondefined drug-cell interactions.
Kusch-Poddar, Manisha
core   +1 more source