Results 221 to 230 of about 120,380 (317)

Isoliensinine exerts antitumor effects in lung adenocarcinoma by inhibiting APEX1-driven ROS production. [PDF]

Front Pharmacol
Chen C, Shu C, Shen D, Yan Z, Liu Z, Huang JA.   +5 more
europepmc   +1 more source

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

Metformin sensitizes triple-negative breast cancer to histone deacetylase inhibitors by targeting FGFR4. [PDF]

J Biomed Sci
Gu Z, Ye F, Luo H, Li X, Gong Y, Mao S, Jia X, Han X, Han B, Fu Y, Cheng X, Li J, Shao Z, Wen P, Hu X, Zhuang Z.   +15 more
europepmc   +1 more source

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Advanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

CAR-T therapy dilemma and innovative design strategies for next generation. [PDF]

Cell Death Dis
Wang Z, Li P, Zeng X, Guo J, Zhang C, Fan Z, Wang Z, Zhu P, Chen Z.   +8 more
europepmc   +1 more source

HIC1 suppresses Tumor Progression and Enhances CD8+ T Cells Infiltration Through Promoting GSDMD‐induced Pyroptosis in Gastric Cancer

Advanced Science, EarlyView.
These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang, Wenqi Du, Lina Ding, Mengdi Wu, Dongsheng Pei   +4 more
wiley   +1 more source

Atractylenolide I inhibits the growth, proliferation and migration of B16 melanoma cells via the PI3K/AKT/mTOR pathway. [PDF]

Oncol Lett
Xu X, Kang P, Che H.
europepmc   +1 more source

Microneedles at the Forefront of Next Generation Theranostics

Advanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang, Yuan Yang, Jiaqi Zhang, Hanrui Zhang, Qian Wang, Shengmei Ma, Pengfei Zhao, Zhou Li, Yuxin Liu   +8 more
wiley   +1 more source

A combinatorial screening protocol for identifying novel and highly potent dual-target inhibitor of BRD4 and STAT3 for kidney cancer therapy. [PDF]

Front Pharmacol
Zhang S, Wu N, Geng Y, Guan L, Niu MM, Li J, Zhu L.   +6 more
europepmc   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source