Results 271 to 280 of about 120,380 (317)

Discovery of highly potent and novel LSD1 inhibitors for the treatment of acute myeloid leukemia: structure-based virtual screening, molecular dynamics simulation, and biological evaluation. [PDF]

Front Pharmacol
Hong Y, Wang Y, Hao Z, Zhang X, Si Y, Lin G, Zhang S, Niu MM, Yang X, Zhang Y.   +9 more
europepmc   +1 more source

High‐Efficiency Carriers’ Separation Strategy Based Ultrasmall‐Bandgap CuWO4 Sono‐Enhances GSH Antagonism for Cuproptosis Cascade Immunotherapy

Advanced Science, EarlyView.
This study prepares copper tungstate (CuWO4, CWO) nanoparticles for synergistic sono‐enhanced cuproptosis‐based cancer therapy. With an ultrasmall bandgap (1.71 eV), CWO facilitates efficient charge carrier separation under ultrasound, enhancing the generation of reactive oxygen species and the controlled release of Cu2+ ions cascade amplify oxidative ...
Lichao Zhu, Zhisheng Guo, Yu Luo, Haiyan Huang, Kexin Zhang, Bingbing Duan, Renmiao Peng, Haochen Yao, Chao Liang, Kaiyang Wang   +9 more
wiley   +1 more source

Targeting phosphatidylserine in tumor cell membranes with a zinc-containing molecule to efficiently combat tumor metastasis. [PDF]

J Nanobiotechnology
Zhou XH, Wang JW, You W, Gao F, Wang Z, Gao HJ, Shen AZ, Ou YH, Zhan X, Nie X, Tang LQ, You YZ.   +11 more
europepmc   +1 more source

Discovery of a Novel and Potent Dual-Targeting Inhibitor of ATM and HDAC2 Through Structure-Based Virtual Screening for the Treatment of Testicular Cancer. [PDF]

Drug Des Devel Ther
Ruan Y, Guan L, Wang Y, Geng Y, Wang X, Niu MM, Yang L, Xu C, Xu Z.   +8 more
europepmc   +1 more source

Concurrent induction of pyroptosis and immunogenic cell death by capsaicin/graphene nanocomplex for enhanced breast cancer immunotherapy. [PDF]

J Nanobiotechnology
Li S, Jin X, Zhang Y, Huang J, Wang H, Meng H, Li J, Zhu L.   +7 more
europepmc   +1 more source

Advances in the Drug Development and Quality Evaluation Principles of Oncolytic Herpes Simplex Virus. [PDF]

Viruses
Ghorab BEA, Liu T, Ying M, Wang P, Qin M, Xing J, Wang H, Xu F.   +7 more
europepmc   +1 more source

Prospects and challenges of ovarian cancer organoids in chemotherapy research (Review). [PDF]

Oncol Lett
Zhang W, Ding Y, He H, Chen K, Zeng Q, Cao X, Xiang Y, Zeng H.   +7 more
europepmc   +1 more source

Investigation of Anticancer Peptides Derived from <i>Arca</i> Species Using In Silico Analysis. [PDF]

Molecules
Wu J, Zhang X, Jin Y, Zhang M, Yu R, Song L, Liu F, Zhu J.   +7 more
europepmc   +1 more source

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Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer

Science Translational Medicine, 2023
Lipid peroxidation–dependent ferroptosis has become an emerging strategy for tumor therapy. However, current strategies not only selectively induce ferroptosis in malignant cells but also trigger ferroptosis in immune cells simultaneously, which can ...
Jingbo Li, Jiao Liu, Zhuan Zhou, Runliu Wu, Xin Chen, Chunhua Yu, Brent R. Stockwell, Guido Kroemer, Rui Kang, D. Tang   +9 more
semanticscholar   +1 more source

Identification of Novel CD39 Inhibitors Based on Virtual Screening and Enzymatic Assays

Journal of Chemical Information and Modeling, 2021
The accumulation of adenosine in the tumor microenvironment mediates immunosuppression and promotes tumor growth and proliferation. Intervention of the adenosine pathway is an important direction of antitumor immunity research.
Yunshuo Zhao, Xiaotong Chen, Zhe Ding, Chuanjie He, Guan-Lun Gao, Sifan Lyu, Yanfeng Gao, Jiangfeng Du   +7 more
semanticscholar   +1 more source