Results 271 to 280 of about 112,008 (305)

Application of molecular dynamics-based pharmacophore and machine learning approaches to identify novel Mcl1 inhibitors through drug repurposing and mechanics research.

Physical Chemistry, Chemical Physics - PCCP
Myeloid cell leukemia 1 (Mcl1), a critical protein that regulates apoptosis, has been considered as a promising target for antitumor drugs. The conventional pharmacophore screening approach has limitations in conformation sampling and data mining.
Han-xun Wang, Zhuo Qi, Wenxiong Lian, Lanyan Ma, Shizun Wang, Haihan Liu, Yu-zhong Jin, Hua-Li Yang, Jian Wang, Maosheng Cheng   +9 more
semanticscholar   +1 more source

Ivosidenib enhances cisplatin sensitivity in ovarian cancer by reducing cancer cell stemness

Cancer Drug Resistance
Aim: Cancer stem cells (CSCs) are pivotal in mediating platinum resistance in ovarian cancer. This study aimed to screen compounds sensitizing CSCs to cisplatin by using a small molecule inhibitor library.
Mengqing Chen, Lin Huang, Simei Zhao, Mengna Zhu, Si Sun, Wenhan Li, Jing Cai, Minggang Peng, Yiping Wen, Zehua Wang   +9 more
semanticscholar   +1 more source

Identification of Novel HPK1 Hit Inhibitors: From In Silico Design to In Vitro Validation

International Journal of Molecular Sciences
Hematopoietic progenitor kinase 1 (HPK1), a negative regulator of T-cells, B-cells, and dendritic cells, has gained attention in antitumor immunotherapy research over the past decade.
Israa H. Isawi, Rayan M. Obeidat, Soraya Alnabulsi, Rufaida Al Zoubi   +3 more
semanticscholar   +1 more source

Thiazolidinones as Potential PGK1 Inhibitors for Treatment of Osteosarcoma Growth and Metastasis.

Journal of Medicinal Chemistry
Osteosarcoma is one of the malignant bone tumors in children and adolescents. Due to unclear pathogenesis and lack of identified drug targets, there has been limited progress in developing targeted therapies in the past 50 years.
Xuwen Chen, Meng Li, Zongjing Hu, Donghui Sun, Yikai Xu, Wenwen Dong, Tong Zhu, Weibin Zhang, Shunying Liu   +8 more
semanticscholar   +1 more source

Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies

Ca-A Cancer Journal for Clinicians, 2022
Paolo Tarantino, Roberto Carmagnani Pestana, Shanu Modi   +2 more
exaly  

A natural products approach to drug discovery: probing modes of action of antitumor agents by genome-scale cDNA library screening.

Methods in molecular biology, 2009
H. Luesch, P. Abreu
semanticscholar   +1 more source

Discovery of New E‐Selectin Inhibitors by Virtual Screening, Fluorescence Binding Assays, and STD NMR Experiments

ChemMedChem, 2016
Pabla A. Barra, V. Jiménez, J. Gavín, A. Daranas, J. Alderete   +4 more
semanticscholar   +1 more source

Apoptosis-based drug screening and detection of selective toxicity to cancer cells

Anti-Cancer Drugs, 2003
O. Frankfurt, A. Krishan
semanticscholar   +1 more source

Targeted drug delivery strategies for precision medicines

Nature Reviews Materials, 2021
Mandana T Manzari, Yosi Shamay, Hiroto Kiguchi   +2 more
exaly  

[Application of renal subcapsular assay to human malignant glioma--a new screening method in vivo for antitumoral drugs].

Gan to kagaku ryoho. Cancer & chemotherapy, 1985
H, Hamada, T, Asakura, K, Matsuda, W, Wechsler, K, Rathmer   +4 more
openaire   +1 more source