Results 231 to 240 of about 3,507,735 (293)

Cell-Based Assays on Microfluidics for Drug Screening

ACS Sensors, 2019
Microfluidics is an appealing platform for drug screening and discovery. Compared with the conventional drug screening methods based on Petri dishes and experimental animals, microfluidic devices have many advantages including miniaturized size, ease-to-use, high sensitivity, and high throughput.
Xingyu Jiang, Xingyu Jiang, Wenfu Zheng
exaly   +3 more sources

Screening for Drugs of Abuse with the Roche ONTRAK Assays

Journal of Analytical Toxicology, 1992
A family of manual, qualitative, latex agglutination inhibition immunoassay screening tests (ONTRAK, Roche) for amphetamines, barbiturates, cocaine, marijuana, morphine, and phencyclidine were evaluated. The assays are inexpensive, rapid, portable, and easy to perform, requiring little training to obtain proficiency.
D A, Armbruster, J M, Krolak
openaire   +2 more sources

Models and screening assays for drug discovery in osteoporosis

Expert Opinion on Drug Discovery, 2010
Osteoporosis affects nearly 100 million people in Europe, Japan and the US, and the number is increasing due to aging of the population. Preclinical efficacy studies performed according to regulatory guidelines are large, long and expensive, and there is a need for guidance and recommendations on how to perform preliminary studies prior to the ...
Jukka P, Rissanen, Jussi M, Halleen
openaire   +2 more sources

Zebrafish assays for drug toxicity screening

Expert Opinion on Drug Metabolism & Toxicology, 2006
Zebrafish are vertebrate organisms that are of growing interest for preclinical drug discovery applications. Zebrafish embryos develop most of the major organ systems present in mammals, including the cardiovascular, nervous and digestive systems, in < 1 week. Additional characteristics that make them advantageous for compound screening are their small
openaire   +2 more sources

Optimization of Cell Viability Assays for Drug Sensitivity Screens

2023
During the preclinical stages of the drug discovery process, cell viability assays are fundamental tools for studying the phenotypic properties and overall health of cells following in vitro drug sensitivity screens. Therefore, it is important to optimize your viability assay of choice to obtain reproducible and replicable results, as well as use ...
Peter, Larsson, Toshima Z, Parris
openaire   +2 more sources

Cell Based Assays for Drug Screening

1997
A CRE-alkaline Phosphatase reporter construct has been introduced into a mammalian cell line to investigate signal transduction pathways used by the calcitonin receptor. Calcitonin activated alkaline Phosphatase production in the CRE-reporter cell line.
Elizabeth Keenan, Helen Kruger, Balwinder Sambi, John S. McLean   +3 more
openaire   +1 more source

Application of a Membrane Fusion Assay for Rapid Drug Screening

Pharmaceutical Research, 1995
The purpose of this study is to develop an in vitro assay for screening drug and their effects on membrane fusion and lysis of intracellular organelles.A 96-well microtiter-dish turbidimetric assay using membrane components of the eggs of sea urchins, a marine invertebrate, was applied to monitor granule fusion and/or lysis.Of 18 drugs screened, 16 had
S S, Vogel, S, Beushausen, D S, Lester
openaire   +2 more sources