Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]
, 2003 The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Couet, William +5 more
core +3 more sources
Eudragit RS100 nanoparticles for sustained release of Cefpodoxime Proxetil: preparation, pharmaceutical characterization, and in-vitro drug release studies [PDF]
Nanomedicine JournalObjective(s): The primary objective of this study was to develop a sustained-release formulation of cefpodoxime proxetil (CP) using the polymer Eudragit RS 100 (ERS100).Materials and Methods: Pluronic F127 (PF127) was incorporated as an amphiphilic ...
Jaya Verma +6 more
doaj +1 more source
Chemical Analysis and Molecular Modelling of Cyclodextrin-Formulated Propofol and Its Sodium Salt to Improve Drug Solubility, Stability and Pharmacokinetics (Cytogenotoxicity) [PDF]
, 2023 Benedikt Wilhelms +2 more
openalex +1 more source
Drugs, Crime, Space, and Time: A Spatiotemporal Examination of Drug Activity and Crime Rates [PDF]
, 2020 To take stock of the “neighborhood effects” of drug activity, we combined theoretical insights from the drugs and crime and communities and place literatures in examining the longitudinal relationship between drug activity and crime rates at more ...
Contreras, C, Hipp, JR
core
Direct measurement of molecular mobility and crystallisation of amorphous pharmaceuticals using terahertz spectroscopy. [PDF]
, 2016 Despite much effort in the area, no comprehensive understanding of the formation and behaviour of amorphous solids has yet been achieved. This severely limits the industrial application of such materials, including drug delivery where, in principle ...
core +2 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Daptomycin: a comparison of two intravenous formulations
Drug Design, Development and Therapy, 2018 Celeste Frankenfeld, Sachin Mittal, Yanira Melendez, Luke Mendez-Vigo, Kenneth C Lamp, Kaitlin N Keller, Shellie R Bertolami Merck & Co., Inc., Kenilworth, NJ, USA Abstract: Daptomycin is a cyclic lipopeptide antibacterial agent with potent ...
Frankenfeld C +6 more
doaj
Compounded Apixaban Suspensions for Enteral Feeding Tubes [PDF]
, 2017 Objective: There is limited information on compounded apixaban formulations for administration via enteral feeding tubes. This study was designed to identify a suitable apixaban suspension formulation that is easy to prepare in a pharmacy setting, is ...
Caraballo, Maria +3 more
core +2 more sources
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Pharmaceutical Technology in Hospital Pharmacy, 2017 In hospitals, a major part of the drugs is administered via the intravenous route. When one wants to evaluate or know the stability of a drug in solution, it is necessary to know several physico-chemical parameters.
Hecq Jean-Daniel +3 more
doaj +1 more source