Results 121 to 130 of about 1,245,796 (337)

Mechanochemical Oxidative Degradation of Thienopyridine Containing Drugs: Toward a Simple Tool for the Prediction of Drug Stability. [PDF]

ACS Cent Sci, 2023
Krake EF, Backer L, Andres B, Baumann W, Handler N, Buschmann H, Holzgrabe U, Bolm C, Beweries T.   +8 more
europepmc   +1 more source

Development of a targeted and controlled nanoparticle delivery system for FoxO1 inhibitors [PDF]

, 2020
Background: Poly (lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) are polymers approved by the United States’ Food and Drug Administration.
Cheng, Zhiyong, Ferrer Vega, Andrea, Imondo, Michael, Lewinski, Nastassja, McInnes, Bridget T., Mulyar, Andriy   +5 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Entecavir: stability and drug-excipient compatibility [PDF]

Brazilian Journal of Pharmaceutical Sciences
Entecavir is an inhibitor of hepatitis B virus (HBV) DNA synthesis that has been widely prescribed in the treatment of chronic infections caused by the virus. Production of generic ETV drugs is an ongoing global endeavor, with particular significance for
Ariadne Botto Fiorot, Clayton Raynan dos Santos, Thiago Padovani Xavier, Taisa Shimosakai de Lira, Marcelo Antonio de Oliveira   +4 more
doaj   +1 more source

A Pilot Stability Study of Dehydroepiandrosterone Rapid-dissolving Tablets Prepared by Extemporaneous Compounding [PDF]

, 2017
Dehydroepiandrosterone supplementation is used to treat a variety of conditions. Rapid-dissolving tablets are a relatively novel choice for compounded dehydroepiandrosterone dosage forms. While rapid-dissolving tablets offer ease of administration, there
Rush, Steven D., Vernak, Charlene, Zhao, Fang   +2 more
core   +1 more source

Review On Drug Stability

This includes drug stability studies Important parameters for new drugs and new drug development pharmaceutical formulation. Durability prediction plays a big role All dosage forms and their drug development Helps determine and suggest storage conditions for each Label description.
openaire   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Replicates Number for Drug Stability Testing during Bioanalytical Method Validation-An Experimental and Retrospective Approach. [PDF]

Molecules, 2022
Gniazdowska E, Goch W, Giebułtowicz J, Rudzki PJ.   +3 more
europepmc   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Impact of Quantisal^® Oral Fluid Collection Device on Drug Stability. [PDF]

Front Toxicol, 2021
Riggio M, Dave KA, Koscak B, Blakey M, Appleton C.   +4 more
europepmc   +1 more source