Results 111 to 120 of about 4,907,325 (259)
Drug Design, Development and Therapy, 2020 Jingsheng Xia,1 Peng Chen2 1Department of Pharmacy, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, Hubei 430060, People’s Republic of China; 2Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060 ...
Xia J, Chen P
doaj
Prediction of Drug Stability Using Deep Learning Approach: Case Study of Esomeprazole 40 mg Freeze-Dried Powder for Solution. [PDF]
Pharmaceutics, 2021 Ajdarić J +4 more
europepmc +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Vesicular drug delivery systems: A novel approach for drug targeting [PDF]
, 2013 The objective of the study is to evaluate the potential of novel vesicular drug delivery systems for drug targeting. Novel vesicular drug delivery systems aim to deliver the drug at a rate directed by need of body during the period of treatment, and ...
Nancy Magon +4 more
core
Long-Term Stability of Glycopyrrolate Oral Solution Galenic Compound at Different Storage Conditions
PharmaceuticsGlycopyrrolate is a competitive muscarinic receptor antagonist used in the treatment of sialorrhea, especially in pediatrics. Degradation research was conducted to better understand the stability of the active pharmaceutical ingredient (API).
Barbara Bellich +11 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
National Campaign Against Drug Abuse Social Issues Survey, 1988
, 2018 Since 1985, as part of the National Campaign Against Drug Abuse, substantial survey research has been undertaken to assess the extent of drug problems, the effectiveness of interventions, and the impact of aspects of the campaign.
Drugs of Dependence Branch, National Drug Abuse Information Centre
core +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source