Results 91 to 100 of about 4,907,325 (259)

Assessing the Impact of Mesoporous, Co-Amorphous, and Polymer-Based Systems on Cefdinir’s Dissolution and Stability Via Predictive Modeling

British Journal of Biomedical Science
The poor solubility and permeability of Biopharmaceutics Classification System (BCS) Class IV drugs pose major challenges to achieving sufficient oral bioavailability and therapeutic efficacy.
Raghad Al Nuss, Mohamad Anas Al Tahan, Hind El-Zein   +2 more
doaj   +1 more source

Dihydropyridines Allosterically Modulate Hsp90 Providing a Novel Mechanism for Heat Shock Protein Co-induction and Neuroprotection

Frontiers in Molecular Biosciences, 2018
Chaperones play a pivotal role in protein homeostasis, but with age their ability to clear aggregated and damaged protein from cells declines. Tau pathology is a driver of a variety of neurodegenerative disease and in Alzheimer's disease (AD) it appears ...
Mark S. Roe, Ben Wahab, Zsolt Török, Ibolya Horváth, László Vigh, Chrisostomos Prodromou   +5 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Drug Stability: ICH versus Accelerated Predictive Stability Studies. [PDF]

Pharmaceutics, 2022
González-González O, Ramirez IO, Ramirez BI, O'Connell P, Ballesteros MP, Torrado JJ, Serrano DR.   +6 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Co-Amorphization, Dissolution, and Stability of Quench-Cooled Drug–Drug Coamorphous Supersaturating Delivery Systems with RT-Unstable Amorphous Components

Background: Supersaturating drug delivery systems (SDDSs) have gained significant attention as a promising strategy to enhance the solubility and bioabsorption of Biopharmaceutics Classification System (BCS) II drugs.
Ying-Hui Ma, Nian-Qiu Shi, Yan-Fei Zhang, Cheng-Yi Hao, Yue Li, Li-Li Zuo, Li-Li Jin, Shang-Qiang Mu, Huan Yu, Di Wu, Qian Yao, Xiao-Ying Lin, Chuang Zhang, Hao Geng, Hui-Feng Zhang   +14 more
core   +1 more source

Perspectives on drugs: Drug consumption rooms: an overview of provision and evidence. [PDF]

, 2016
Supervised drug consumption facilities, where illicit drugs can be used under the supervision of trained staff, have been operating in Europe for the last three decades.

core  

Diluted Etilefrine for Neonatal Chylothorax: A 96-Hour Physicochemical Stability Study

Pharmaceutics
Background/Objectives: Etilefrine is a sympathomimetic agent increasingly used off-label as a rescue therapy for refractory neonatal chylothorax. For continuous intravenous administration in neonates, the commercially available 10 mg/mL formulation ...
Louisa Bourel, Sixtine Gilliot, Zeina Boulos, Yousra Alouadni, Kévin Le Duc, Mohamed Riadh Boukhris, Laurent Storme, Anthony Martin Mena, Pascal Odou   +8 more
doaj   +1 more source

Mechanochemical Oxidative Degradation of Thienopyridine Containing Drugs: Toward a Simple Tool for the Prediction of Drug Stability. [PDF]

ACS Cent Sci, 2023
Krake EF, Backer L, Andres B, Baumann W, Handler N, Buschmann H, Holzgrabe U, Bolm C, Beweries T.   +8 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source