Results 91 to 100 of about 719,644 (307)

Sorbitol based proniosomes to improve the permeability and stability of an oral cephlosporin [PDF]

, 2012
In the present study, dry free-flowing proniosomes containing Cefuroxime axetil has been prepared with sorbitol. Span 40, 60 and 80 have been used in different molar ratios with cholesterol and stearylamine.
Singh, Bishambar; PHTI, SMS Medical Collage & Hospital Jaipur, Rajasthan 302017, Paliwal, Sarvesh; Department of Pharmacy Banasthali University Niwai, Tonk Rajasthan, Mishra, Prabhat Ranjan; CDRI, Lucknow, India, Sambhakar, Sharda; Department of Pharmacy Banasthali University Niwai, Tonk Rajasthan   +3 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

THE IMPORTANCE OF CHROMATOGRAPHICALLY PURIFIED EXCIPIENTS

Разработка и регистрация лекарственных средств, 2019
In the present work critical importance and benefits of Super Refined excipients for drug stability, integrity and safety are described. It was shown, that impurities can disrupt API and cause cell irritation.
G. J. Rizzo, K. H. Chen
doaj  

Superparamagnetic Iron Oxide Nanoparticles Encapsulated in Biodegradable Thermosensitive Polymeric Micelles: Toward a Targeted Nanomedicine Suitable for Image-Guided Drug Delivery

, 2009
Superparamagnetic iron oxide nanoparticles (SPIONs) have been receiving great attention lately due to their various biomedical applications, such as in MR imaging and image guided drug delivery.
Seevinck, P.R., Talelli, M., Dep Farmaceutische wetenschappen, van Nostrum, C.F., Rijcken, C.J.F., Lammers, T., Storm, G., Hennink, W.E., Advanced drug delivery systems/drug targeting   +8 more
core  

Combining Ultra-High Drug Loaded Micelles and Shear Thinning, Injectable Hydrogel Drug Depots for Prolonged Drug Release

, 2019
Hydrogel based drug depot formulations are of great interest for therapeutic applications. Here, the impact of incorporated drug, neat polymer micelles, and drug-loaded micelles on the viscoelastic properties of a cytocompatible hydrogel was ...
Michael M, Lübtow, Florian-Kai, Gröber-Becker, Thomas, Lorson, Robert, Luxenhofer, Tamara, Finger   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Nanoparticle-Based Strategy to Stabilize 5-Azacytidine and Preserve DNA Demethylation Activity in Human Cardiac Fibroblasts

Pharmaceutics
Background: 5-Azacytidine (5-Aza) is a clinically important DNMT inhibitor with the potential to modulate cardiac remodeling by epigenetically reprogramming human cardiac fibroblasts (HCFs).
Kantaporn Kheawfu, Chuda Chittasupho, Sudarshan Singh, Siriporn Okonogi, Narainrit Karuna   +4 more
doaj   +1 more source

Criteria for Judging the Quality of a Publication on Physicochemical Stability of Ready to Use Injectable Drugs

Pharmaceutical Technology in Hospital Pharmacy, 2017
In hospitals, a major part of the drugs is administered via the intravenous route. When one wants to evaluate or know the stability of a drug in solution, it is necessary to know several physico-chemical parameters.
Hecq Jean-Daniel, Bihin Benoit, Jamart Jacques, Galanti Laurence   +3 more
doaj   +1 more source

Dihydropyridines Allosterically Modulate Hsp90 Providing a Novel Mechanism for Heat Shock Protein Co-induction and Neuroprotection

Frontiers in Molecular Biosciences, 2018
Chaperones play a pivotal role in protein homeostasis, but with age their ability to clear aggregated and damaged protein from cells declines. Tau pathology is a driver of a variety of neurodegenerative disease and in Alzheimer's disease (AD) it appears ...
Mark S. Roe, Ben Wahab, Zsolt Török, Ibolya Horváth, László Vigh, Chrisostomos Prodromou   +5 more
doaj   +1 more source

Glycopeptide antibiotic drug stability in aqueous solution. [PDF]

AAPS Open, 2022
Jakaria SM, Budil DE, Murtagh J.
europepmc   +1 more source