Results 71 to 80 of about 1,390,034 (354)

Influence of variability in starting materials quality on stability of finished drug products: a quality-by-design factor and response [PDF]

, 2012
The use of ill selected excipients in drug formulations can have a significant influence on the overall stability. Therefore, evaluation of chemical and physical excipient compatibility with the API has become a major part in the development of new drug ...
Bauters, Tieneke, D'Hondt, Matthias, De Spiegeleer, Bart, Robays, Hugo, Vandenbroucke, Johan, Wynendaele, Evelien   +5 more
core   +1 more source

Nuclear DNA and protein content evaluation in Taxus plant cell cultures using multiparameter flow cytometry [PDF]

, 2009
Plant cell cultures of Taxus provide the most reliable production methods for the anti-cancer drug paclitaxel. In order to comprehend the inherent culture heterogeneity and production variability in cell cultures, it is essential that the cellular ...
Amit Shavit, Susan C. Roberts, Vishal Gaurav   +2 more
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizadores e cortadores de comprimidos: riscos e restrições ao uso Organizadores y cortadores de comprimidos: riesgos y restricciones del uso Pill organizers and pill cutters: risks and limitations

Revista de Saúde Pública, 2013
Com base em análise documental, foram discutidas e problematizadas as limitações associadas à utilização de organizadores e cortadores de comprimidos, como questão de saúde pública. Os organizadores destinados ao armazenamento e transporte de comprimidos
Caroline Ribeiro de Borja-Oliveira
doaj  

Long-term stability of liposomal mycobacteriophage D29: A comprehensive in vitro assessment

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. The spread of antibiotic-resistant mycobacteria necessitates new therapeutic approaches for tuberculosis, phage therapy being one of them.
V. V. Avdeev, M. B. Lapenkova, M. A. Vladimirsky   +2 more
doaj   +1 more source

The Use of Poly(vinyl alcohol)-based Hydrogels in Biomedical Applications [PDF]

, 2018
Polymers have found increasing favor in biomedical applications due to the greater control that researchers can exert over their properties. Researchers have focused on the development of therapies using biologically compatible polymers due to their ...
Subramanian, Deepak
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Generation and characterisation of Friedreich ataxia YG8R mouse fibroblast and neural stem cell models [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Background: Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by GAA repeat expansion in the first intron of the FXN gene, which encodes
A Durr, A Filla, A Halabi, A Hick, A Rotig, A Wong, AH Koeppen, AL Bulteau, AM Khalil, Annalisa Pastore, BL Sopher, C Gellera, C Sandi, CH Zuhlke, Chiranjeevi Sandi, D Marmolino, D Marmolino, D Waldvogel, DH Cho, DW Chung, E Greene, F Foury, G Coppola, G Tan, GS Chandok, H Holemon, H Puccio, H Puccio, H Van Remmen, Harvinder Jassal, I Castaldo, I De Biase, I De Biase, J Du, J Liu, J St-Pierre, JB Schulz, JH Willis, JL Bradley, JL García-Giménez, JP Sarsero, L Grant, L Montermini, L Pianese, L Schols, M Anheim, M Cossee, M Pandolfo, M Perdomini, MA Pook, Madhavi Sandi, Mark A. Pook, ML Moseley, MM Heidari, MM Lufino, MV Evans-Galea, MV Evans-Galea, N Calmels, N Sakamoto, PD Ladd, R Sharma, RA Vaubel, RL Bourn, RM Clark, S Al-Mahdawi, S Al-Mahdawi, S Al-Mahdawi, S Al-Mahdawi, S Ku, Sahar Al-Mahdawi, Sara Anjomani-Virmouni, SW Levison, T Geng, V Campuzano, V Campuzano, V Ezzatizadeh, Vahid Ezzatizadeh, Y Shan   +77 more
core   +2 more sources