Results 71 to 80 of about 719,644 (307)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Physicochemical stability of ternary admixtures of butorphanol, ketamine, and droperidol in polyolefin bags for patient-controlled analgesia use

Drug Design, Development and Therapy, 2016
Baoxia Fang,1 Linhai Wang,2 Junfeng Gu,3 Fuchao Chen,1 Xiao-ya Shi1 1Department of Pharmacy, Dongfeng Hospital, 2Department of Pharmacy, 3Department of Anesthesiology, Renmin Hospital, Hubei University of Medicine, Hubei, People’s Republic of
Fang BX, Wang LH, Gu JF, Chen FC, Shi XY
doaj  

Design of Experiment assisted development of stability-indicating LC method for fenticonazole cream analysis in presence of degradation product

Revista de Ciências Farmacêuticas Básica e Aplicada, 2020
Fenticonazole is an antifungal drug widely used in a cream formulation including as a generic medicine. Stability studies of fenticonazole in a cream formulation are very scarce.
Thais Araújo Silva, Josilene Correa, Hérida Regina Nunes Salgado   +2 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Physical Compatibility and Chemical Stability of Fentanyl and Naloxone Hydrochloride in 0.9% Sodium Chloride Injection Solution for Patient-Controlled Analgesia Administration

Drug Design, Development and Therapy, 2020
Peng Chen,1,* Fuchao Chen,2,* Jiexin Lei,3 Benhong Zhou1 1Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, People’s Republic of China; 2Department of Pharmacy, Dongfeng Hospital, Hubei University of Medicine, Shiyan,
Chen P, Chen F, Lei J, Zhou B
doaj  

Physicochemical and Microbiological Stability of a New Oral Clonidine Solution for Paediatric Use

Pharmaceutical Technology in Hospital Pharmacy, 2018
As many drugs are unavailable for paediatric use, hospital pharmacies are often required to develop suitable formulations themselves. Clonidine is commonly used in paediatrics (in severe hypertension, in opiate withdrawal syndrome, in tics and Gilles de ...
Verlhac Camille, Lannoy Damien, Bourdon Florence, Titecat Marie, Frealle Emilie, Nassar Carole, Berneron Christophe, Odou Pascal   +7 more
doaj   +1 more source

Effectivness Bank Bulletin [Drug policy: evidence for effective interventions]. [PDF]

, 2013
Drug policy and the public good: evidence for effective interventions. Strang J., Babor T., Caulkins J. et al. Lancet: 2012, 379(9810), p. 71–83. Review of relevant research by an international team of leading researchers offers policymakers guidance ...

core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Cyclodextrins and Their Derivatives as Drug Stability Modifiers. [PDF]

Pharmaceuticals (Basel), 2023
Aiassa V, Garnero C, Zoppi A, Longhi MR.
europepmc   +1 more source

Stability Studies of a Tetraethyl Orthosilicate-Based Thixotropic Drug Delivery System

Background/Objectives: This study assessed the effects of formulation components on the long-term stability of a previously described tetraethyl orthosilicate-based drug delivery system.
Kolton C. Sandau, Elizabeth M. Arrigali, Monica A. Serban, Bogdan A. Serban, Emma Barrett-Catton   +4 more
core   +1 more source