Results 61 to 70 of about 719,644 (307)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

PDST:Protein Drug Stability Tuner a web server to improve the stability of protein drug

, 2009
[[abstract]]The drug stability include half life and ADME are the important factors that influence the drug efficacy. However, the resource of a number of drugs are come from proteins or peptides, which can be modified and reconstituted for every purpose.
Yueh-Feng Wu
core  

Dextran and its potential use as tablet excipient [PDF]

, 2015
Dextrans are a class of carbohydrate polymers extensively applied in pharmaceutical applications, particularly as drug conjugate macromolecular carriers or drug delivery systems.
D. R. Perinelli, G. Bonacucina, G. F. Palmieri, Bonacucina, Giulia, Palmieri, Giovanni Filippo, Casettari, Luca, P. Lucaioli, PERINELLI, DIEGO ROMANO, Cespi, Marco, L. Casettari, Perinelli, Diego R., G. A. Morris, Morris, Gordon A., Lucaioli, Paolo, M. Cespi   +14 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Assessing the Impact of Mesoporous, Co-Amorphous, and Polymer-Based Systems on Cefdinir’s Dissolution and Stability Via Predictive Modeling

British Journal of Biomedical Science
The poor solubility and permeability of Biopharmaceutics Classification System (BCS) Class IV drugs pose major challenges to achieving sufficient oral bioavailability and therapeutic efficacy.
Raghad Al Nuss, Mohamad Anas Al Tahan, Hind El-Zein   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Development of a Novel Controlled Release Drug Delivery System

, 2007
The aim of this research was to formulate, characterise and assess the feasibility of a novel drug delivery system known as the in situ gelling matrix (ISGM) where a hydrophilic polymer is suspended in a non-aqueous solvent that converts into a gel when ...
Babu, Kavitha Mary Vadakkel
core  

Study to design stable lansoprazole pellets [PDF]

, 2008
Pharmaceutical product development is a complex and creative design process, that involves many factors, many unknowns, many disciplines and has a multiple iterations and a long lifecycle.
Pasic, Maja
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Remotely triggered scaffolds for controlled release of pharmaceuticals [PDF]

, 2013
Fe3O4-Au hybrid nanoparticles (HNPs) have shown increasing potential for biomedical applications such as image guided stimuli responsive drug delivery.
McGarvey, David J., David McGarvey, Martin Lees, Clare Hoskins, Hoskins, Clare, Roach, Paul, Ph.D., Lees, Martin R., Paul Roach   +7 more
core   +1 more source