Results 61 to 70 of about 1,390,034 (354)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Stability of diluted chlorhexidine for skin testing in drug allergy evaluations

Journal of Allergy and Clinical Immunology: Global
Background: Chlorhexidine gluconate (CHX), a common cause of perioperative anaphylaxis, is frequently used for skin testing in allergy evaluations. Although CHX’s maximal nonirritating concentrations are known, the stability of its dilutions for skin ...
Divya Shah, MD, Gabriel Cojuc-Konigsberg, BS, Stacy D. Brown, PhD, Sergio E. Chiarella, MD, Gerald W. Volcheck, MD, Hirohito Kita, MD, Lene H. Garvey, MD, PhD, Alexei Gonzalez-Estrada, MD   +7 more
doaj   +1 more source

Forced degradation studies to identify organic impurities in pharmaceuticals: a Brazilian perspective

Revista de Ciências Farmacêuticas Básica e Aplicada, 2021
Objective: The aim of this study was to highlight and sediment the necessary steps to be followed while conducting forced degradation studies to identify degradation products and to describe the Brazilian and international regulations associated with ...
Fernanda Fernandes Farias, Valéria Adriana Pereira Martins, Helena Miyoco Yano, Luz Marina Trujillo, Ernani Pinto   +4 more
doaj  

Solid lipid dispersion of calcitriol with enhanced dissolution and stability [PDF]

, 2011
Solid dispersion of calcitriol with lipophilic surfactants and triglycerides was developed by melt-mixing method to modify the release and enhance stability of the drug. The solid dispersions were characterized by differential scanning calorimetry (DSC),
Yuan, Ting, Qin, Lingzhen, Wang, Zhouhua, Nie, Jinyuan, Guo, Zhefei, Li, Ge, Wu, Chuanbin   +6 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microdevices for extensional rheometry of low viscosity elastic liquids : a review [PDF]

, 2013
Extensional flows and the underlying stability/instability mechanisms are of extreme relevance to the efficient operation of inkjet printing, coating processes and drug delivery systems, as well as for the generation of micro droplets. The development of
A Bazilevsky, AG Balducci, AG Banpurkar, AM Ardekani, B Berge, C Pipe, C Pipe, CG Hermansky, CJS Petrie, CJS Petrie, CW Macosko, DR Link, E Bänsch, ESG Shaqfeh, F Mugele, F. J. Galindo-Rosales, FR Phelan Jr, FT Trouton, G Beni, GG Fuller, GH McKinley, GH McKinley, GH McKinley, GI Taylor, GM Whitesides, H Münsted, HA Barnes, HCH Bandalusena, HP Babcock, J Husny, J Meissner, J Meissner, J Remmelgas, J Soulages, J Wang, JA Odell, JA Pathak, JE Matta, JH Song, JM Maia, JP Rothstein, JP Rothstein, JS Lee, K Niedzwiedz, K Niedzwiedz, K Nijenhuis, L Campo-Deaño, L Campo-Deaño, LE Rodd, LE Rodd, LE Rodd, M Padmanabhan, M Padmanabhan, M Roche, M Sentmanat, M Tanyeri, M Tanyeri, M. A. Alves, M. S. N. Oliveira, MA Alves, MG Pollack, MK Tan, MSN Oliveira, MSN Oliveira, MSN Oliveira, MSN Oliveira, MSN Oliveira, MSN Oliveira, MSN Oliveira, MSN Oliveira, N Kojic, N Kumari, P Becherer, P Dontula, P Erni, P Guillot, P Guillot, PC Sousa, PE Arratia, PE Arratia, PK Bhattacharjee, R Dylla-Spears, R Sattler, R Zheng, RB Bird, RI Tanner, RJ Poole, RR Lagnado, S Gaudet, S Ríos, SD Hudson, SJ Haward, SJ Haward, SJ Haward, SL Anna, SL Anna, SL Anna, SL Ng, SS Hsieh, T Cubaud, T Funami, T Schweizer, T Sridhar, TM Squires, TM Squires, TT Perkins, W Lee, WC Nelson, WW Schultz, YY Lin   +109 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Pharmaceutical compounding of orphan active ingredients in Belgium : how community and hospital pharmacists can address the needs of patients with rare diseases [PDF]

, 2019
Background: Pharmaceutical compounding of orphan active ingredients can offer cost-effective treatment to patients when no other drug product is available for a rare disease or during periods of drug product shortages.
Boussery, Koen, De Spiegeleer, Bart, Peeters, E, Remon, Jean Paul, Van Tongelen, Inge, Vanhoorne, Valérie, Vervaet, Chris, Wynendaele, Evelien   +7 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Nanoparticle-Based Strategy to Stabilize 5-Azacytidine and Preserve DNA Demethylation Activity in Human Cardiac Fibroblasts

Pharmaceutics
Background: 5-Azacytidine (5-Aza) is a clinically important DNMT inhibitor with the potential to modulate cardiac remodeling by epigenetically reprogramming human cardiac fibroblasts (HCFs).
Kantaporn Kheawfu, Chuda Chittasupho, Sudarshan Singh, Siriporn Okonogi, Narainrit Karuna   +4 more
doaj   +1 more source