Results 241 to 250 of about 8,084,609 (393)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Barcoding chemical modifications into nucleic acids improves drug stability in vivo.

J Mater Chem B, 2018
Sago CD, Kalathoor S, Fitzgerald JP, Lando GN, Djeddar N, Bryksin AV, Dahlman JE.   +6 more
europepmc   +1 more source

Stability indicating hptlc method development and validation for the estimation of celecoxib in bulk drug and its pharmaceutical formulation

, 2020
Kalyani U. Shelar, Janhavi R Rao, Chaitali Dhale   +2 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

ASSESSMENT OF THE BIOCOMPATIBILTY, STABILITY, AND SUITABILITY OF NATURAL AND SYNTHETIC POLYMERS AND DRUGS IN THE FDA APPROVAL PROCESS

, 2019
Phuong Anh Hoang Nguyen
openalex   +1 more source

Polymeric Advancements in Transdermal Drug Delivery: A Comprehensive Review on Stability, Safety, and Biocompatibility [PDF]

Arvind Raghav, Vaibhav Rastogi, Phool Chandra, A. Elphine Prabahar, Amit Verma, Urvashi Rahul Saxena, Sumit Durgapal, Bhavana Singh, Anurag Verma   +8 more
openalex   +1 more source

Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery

Chem, 2017
Isabel Abánades Lázaro, Salame Haddad, Sabrina Sacca, Claudia Orellana-Tavra, D. Fairen-jimenez, Ross S. Forgan   +5 more
semanticscholar   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

An Overview of Liquid Chromatography-Mass Spectrometry (LC-MS) Methods for the Quantification of Antibody-Drug Conjugates. [PDF]

Biomed Chromatogr
Buitelaar PLM, Rosing H, Beijnen JH, Steeghs N, Huitema ADR.   +4 more
europepmc   +1 more source