Results 241 to 250 of about 634,895 (315)

Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open‐Label, Phase 1 Trial

Arthritis Care &Research, EarlyView.
Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner, Anna Shmagel, Gerd Horneff, Ivan Foeldvari, Jordi Antón, Athimalaipet V. Ramanan, Yuli Qian, Kristina Unnebrink, Shuai Hao, Heidi S. Camp, Nasser Khan, Wei Liu, Mohamed‐Eslam F. Mohamed   +12 more
wiley   +1 more source

A DFT investigation of the adsorption mechanism of paclitaxel on functionalized graphene oxide for enhanced drug delivery. [PDF]

Sci Rep
Huwaimel B, Alqarni S.
europepmc   +1 more source

Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink

Arthritis Care &Research, EarlyView.
Objective The main objective of this study is to examine the safety of oral acetaminophen at its therapeutic dose in adults aged ≥65 years. Methods This population‐based cohort study used the Clinical Practice Research Datalink‐Gold data. Participants were aged ≥65 years registered with a UK general practice for at least 12 months between 1998 and 2018.
Jaspreet Kaur, Georgina Nakafero, Abhishek Abhishek, Christian Mallen, Michael Doherty, Weiya Zhang   +5 more
wiley   +1 more source

Targeting Oncoprotein Stability Overcomes Drug Resistance Caused by FLT3 Kinase Domain Mutations

, 2014
Chuanjiang Yu, Rama Krishna Kancha, Justus Duyster   +2 more
openalex   +2 more sources

Association of Changes in Hand Pain With BMI, Employment, and Mental Well‐Being Over Four Years in Patients With Hand Osteoarthritis

Arthritis Care &Research, EarlyView.
Objective We aimed to characterize patients with hand osteoarthritis (OA) with deteriorating or improving hand pain and to investigate patients achieving good clinical outcome after four years. Methods We used four‐year annual Australian/Canadian Hand Osteoarthritis Index (AUSCAN) pain subscale (range 0–20) measurements from the Hand OSTeoArthritis in ...
Coen van der Meulen, Lotte A. van de Stadt, Saskia J. Buck, Frits R. Rosendaal, Sietse E. S. Terpstra, Margreet Kloppenburg   +5 more
wiley   +1 more source

Microfluidic synthesis of stable and uniform curcumin-loaded solid lipid nanoparticles with high encapsulation efficiency. [PDF]

RSC Adv
Kim ST, Lee HM, Jung JH, Kook JW.
europepmc   +1 more source

Rapid Stability Indicating RP-HPLC Method for Simultaneous Quantification of Related Impurities of Antiretroviral Drugs

, 2015
J. Kalpana, M. Himaja, C. Anbarasu
openalex   +1 more source

Global Trends in Risk Factors for Low Back Pain: An Analysis of the Global Burden of Disease Study Data From 1990 to 2021

Arthritis Care &Research, EarlyView.
Objective The increasing burden associated with low back pain (LBP) is a critical issue. This is a novel analysis of trends in risk factors for LBP aiming to identify risk factors that require further attention or consideration in global policies to reduce the burden of LBP.
Katharine E. Roberts, Manuela L. Ferreira, Paula R. Beckenkamp, Sneha Nicholson, Lyn March, Paulo H. Ferreira   +5 more
wiley   +1 more source

Glassy Drug Microneedle Array Design: Drug Glass-Forming Ability and Stability. [PDF]

Mol Pharm
Elkhashab M, Sartawi Z, Faisal W, Crean A.   +3 more
europepmc   +1 more source

Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

, 2015
Amjad Alhalaweh, Ahmad Alzghoul, Denny Mahlin, Christel A. S. Bergström   +3 more
openalex   +1 more source