Results 261 to 270 of about 634,895 (315)

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Modified diatom-based ocular suspension for sustained diclofenac sodium delivery: a novel drug carrier approach. [PDF]

BMC Pharmacol Toxicol
Ghasemi Shayan R, Jalaei D, Dobakhti F.
europepmc   +1 more source

Scaling Up Synthetic Cell Production Using Robotics and Machine Learning Toward Therapeutic Applications

Advanced Biology, EarlyView.
Synthetic cells (SCs) hold great promise for biomedical applications, but manual production limits scalability. This study presents an automated method for large‐scale SC synthesis, integrating robotic liquid handling and machine learning‐driven high‐throughput characterization.
Noga Sharf‐Pauker, Ido Galil, Omer Kfir, Gal Chen, Rotem Menachem, Jeny Shklover, Avi Schroeder, Shanny Ackerman   +7 more
wiley   +1 more source

Development of donepezil hydrochloride-loaded PLGA-based nanoparticles for Alzheimer's disease treatment. [PDF]

Sci Rep
Kömür M, Kıyan HT, Öztürk AA.
europepmc   +1 more source

Toward Design Principles for Biomolecular Condensates for Metabolic Pathways

Advanced Biology, EarlyView.
Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André, Nikita Rehnberg, Ankush Garg, Magnus Kjærgaard   +3 more
wiley   +1 more source

Employing Automated Machine Learning (AutoML) Methods to Facilitate the <i>In Silico</i> ADMET Properties Prediction. [PDF]

J Chem Inf Model
Han H, Shaker B, Lee JH, Choi S, Yoon S, Singh M, Basith S, Cui M, Ahn S, An J, Kang S, Yeom MS, Choi S.   +12 more
europepmc   +1 more source

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

Quantification of Methylene Blue and Evaluation of Its Pharmacokinetics in ICR Mice by Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry Using Difluoroacetic Acid. [PDF]

Biomed Chromatogr
Park SJ, Lee J, Hwang S, Lim JH, Cho H, Shin YG.   +5 more
europepmc   +1 more source

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source

Structure-guided screening identified bioactive phytoconstituents Hernandonine and Anolobine as potential inhibitors of dual specificity protein kinase CLK1. [PDF]

Sci Rep
Khan S, Choudhury A, Mohammad T, Shamsi A, Hassan MI, Islam A.   +5 more
europepmc   +1 more source