Results 31 to 40 of about 7,888,866 (398)
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
eLife, 2021 BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA damage ...
Xiangrong Chen +13 more
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Review of binary, ternary and quaternary mixtures for induction and maintenance of opioid free anesthesia [PDF]
Farmacia Hospitalaria, 2021 Objective: To describe and organize the current information available on binary, ternary and/or quaternary mixtures used in opioid-free anesthesia (OFA), as well as their physicochemical stability, in order to facilitate its correct administration ...
Beatriz Tauste-Hernández +3 more
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Pharmaceutics, 2023 Background: Stability study of a 10 mg/mL injectable cisatracurium solution stored refrigerated in amber glass ampoules for 18 months (M18). Methods: 4000 ampoules were aseptically compounded using European Pharmacopoeia (EP)-grade cisatracurium besylate,
Marine Roche +7 more
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Challenges of Dissolution Methods Development for Soft Gelatin Capsules
Pharmaceutics, 2021 Recently, the development of soft gelatin capsules (SGCs) dosage forms has attracted a great deal of interest in the oral delivery of poorly water-soluble drugs.
Festo Damian +4 more
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Molecules, 2021 The evolution of different antimicrobial drugs in terrestrial, microgravity and hypergravity conditions is presented within this review, in connection with their implementation during human space exploration.
Ágota Simon +3 more
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Molecules, 2022 In past decades, anticancer research has led to remarkable results despite many of the approved drugs still being characterized by high systemic toxicity mainly due to the lack of tumor selectivity and present pharmacokinetic drawbacks, including low ...
Giuseppina Ioele +6 more
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Crystals, 2023 Pyrazinamide may exist in at least four known polymorphic forms, which were obtained experimentally. One of these polymorphs, (α), shows outstanding mechanical properties, demonstrating a significant anisotropic plasticity in a three-point bending test ...
Aleksandr S. Dubok, Denis A. Rychkov
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Molecular Pharmaceutics, 2021 Amorphous solid dispersions (ASDs) are of great interest due to their ability to enhance the delivery of poorly soluble drugs. Recent studies have shown that, in addition to acting as a crystallization inhibitor, the polymer in an ASD plays a role in ...
Tze Ning Hiew, D. Zemlyanov, L. Taylor
semanticscholar +1 more source
Machine Learning Predicts Drug Metabolism and Bioaccumulation by Intestinal Microbiota
Pharmaceutics, 2021 Over 150 drugs are currently recognised as being susceptible to metabolism or bioaccumulation (together described as depletion) by gastrointestinal microorganisms; however, the true number is likely higher.
Laura E. McCoubrey +5 more
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In vitro and in vivo screening for novel essential cell-envelope proteins in Pseudomonas aeruginosa [PDF]
, 2015 The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required.
Bragonzi, Alessandra +5 more
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