Results 31 to 40 of about 8,056,631 (393)

Challenges of Colistin Use in ICU and Therapeutic Drug Monitoring: A Literature Review

Antibiotics, 2023
The emerging resistance of Gram-negative bacteria is a growing problem worldwide. Together with the financial cost, limited efficacy, and local unavailability of newer antibiotics or their combinations, it has led to the reintroduction of colistin as a ...
Jitka Rychlíčková, Vendula Kubíčková, Pavel Suk, Karel Urbánek   +3 more
doaj   +1 more source

Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter pylori [PDF]

, 2015
Objectives: There are various obstacles in the eradication of Helicobacter.pylori (H. pylori) infections, including low antibiotic levels and poor accessibility of the drug at the site of the infection.
Adebisi, Adebisi, Adeola O. Adebisi, Ahuja, Akiyama, Bai, Bajpai, Barbara R. Conway, Batchelor, Bazzoli, Boddupalli, Cammarota, Castro, Chun, Desai, Dunn, Dupuy, Erah, Erah, Ernst, Gal, Georgopoulos, Gåserød, Higuchi, Hixson, Iijima, Ikeda, Ishak, Kawahara, Khanvilkar, Kohri, Korsmeyer, Lee, Lehmann, Malfertheiner, Miyazaki, Moore, Murata, Murray, Najib, Nakagawa, Nayak, Norris, Park, Pasparakis, Pereira, Peter R. Laity, Peterson, Rajinikanth, Romero, Rothenbacher, Singh, Smrdel, Stops, Suerbaum, Suzuki, Umamaheshwari, Varum, Whitehead, Østberg   +59 more
core   +1 more source

Rapid Study on Mefloquine Hydrochloride Complexation with Hydroxypropyl-β-Cyclodextrin and Randomly Methylated β-Cyclodextrin: Phase Diagrams, Nuclear Magnetic Resonance Analysis, and Stability Assessment

Pharmaceutics, 2023
This study investigates the complexation of mefloquine hydrochloride by cyclodextrins to improve its solubility in order to design an oral solution.
Amaury Durand, David Mathiron, Sébastien Rigaud, Florence Djedaini-Pilard, Frédéric Marçon   +4 more
doaj   +1 more source

Development of a predictive model for the long term stability assessment of drug-in-adhesive transdermal films using polar pressure sensitive adhesives as carrier/matrix. [PDF]

, 2017
Drug crystallization in transdermal drug delivery systems is a critical quality defect. The impact of drug load and hydration on the physical stability of polar (acrylic) drug-in-adhesive (DIA) films was investigated with the objective to identify ...
Ashton, Mark, Chenevas-Paule, Clemence, Dodou, Kalliopi, Schubert, Martin, Wolff, Hans   +4 more
core   +1 more source

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. [PDF]

, 2015
Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain.
Caddick, S, Chester, KA, Chudasama, V, Maruani, A, Miranda, E, Smith, ME   +5 more
core   +1 more source

Adaptive HIV-1 evolutionary trajectories are constrained by protein stability [PDF]

, 2017
Despite the use of combination antiretroviral drugs for the treatment of HIV-1 infection, the emergence of drug resistance remains a problem. Resistance may be conferred either by a single mutation or a concerted set of mutations.
Kandathil, Shaun M., Lovell, Simon C., Olabode, Abayomi S., Robertson, David L.   +3 more
core   +2 more sources

Lignin-Based Spherical Structures and Their Use for Improvement of Cilazapril Stability in Solid State

Molecules, 2020
Biopolymer-based spherical particles exhibit unique properties including narrow sizes and many functional groups on their surfaces. Therefore, they show great potential for application in many scientific and industrial processes.
Małgorzata Stanisz, Łukasz Klapiszewski, Dariusz T. Mlynarczyk, Beata J. Stanisz, Teofil Jesionowski   +4 more
doaj   +1 more source

EVALUATION OF THE STABILITY OF VIGABATRIN IN HOSPITALAR EXTEMPORANEOUS FORMULATIONS

Drug Analytical Research, 2019
The aim of this study was to analyze the chemical stability of the anticonvulsant vigabatrin extemporaneous formulation from tablets in storage conditions of different temperatures and types of packaging used.
Marcio Vinicius Ayres, Sarah Chagas Campanharo, Elfrides Schapoval, Nathalie Ribeiro Wingert, Martin Steppe   +4 more
doaj   +1 more source

An Approach to Drug Stability Studies and Shelf-life Determination

Archives of Current Research International, 2019
The main objective of carrying out stability studies of the drug product is to establish shelf life of drug during storage. Stability of drug is defined as “The capability of a particular formulation in a specific container/closed system, to remain ...
Ekta Tembhare, K. R. Gupta, M. Umekar
semanticscholar   +1 more source

Trisulfide bond–mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity

Science Advances, 2020
Trisulfide bond enhances the stability and GSH sensitivity of doxorubicin dimeric prodrug nanoassemblies. Rational design of nanoparticulate drug delivery systems (nano-DDS) for efficient cancer therapy is still a challenge, restricted by poor drug ...
Yinxian Yang, Bingjun Sun, Shiyi Zuo, Ximu Li, Shuang Zhou, Lingxiao Li, C. Luo, Hongzhuo Liu, M. Cheng, Yongjun Wang, Shujun Wang, Zhonggui He, Jin Sun   +12 more
semanticscholar   +1 more source