Results 31 to 40 of about 634,895 (315)
Mathematical Modeling of Drug Use: The Dynamics of Monosubstance Dependence for Two Addictive Drugs [PDF]
The Pi Mu Epsilon Journal, Vol. 14, No. 7, pp. 449-462. 2017, 2022 Based on previous work done in this field, we build a dynamical system that describes changes in drug addiction in an isolated population when two addictive substances are available simultaneously. We then use our model to investigate whether the system captures the process of users switching drug habits.
arxiv
Mesoporous Silica as a Carrier for Amorphous Solid Dispersion [PDF]
British Journal of Pharmaceutical research,2017, Vol 16, Issue 6,
pages 1-19, 2017 In the past decade, the discovery of active pharmaceutical substances with high therapeutic value but poor aqueous solubility has increased, thus making it challenging to formulate these compounds as oral dosage forms. The bioavailability of these drugs can be increased by formulating these drugs as an amorphous drug delivery system.
arxiv +1 more source
Drugs Resistance Analysis from Scarce Health Records via Multi-task Graph Representation [PDF]
arXiv, 2023 Clinicians prescribe antibiotics by looking at the patient's health record with an experienced eye. However, the therapy might be rendered futile if the patient has drug resistance. Determining drug resistance requires time-consuming laboratory-level testing while applying clinicians' heuristics in an automated way is difficult due to the categorical ...
arxiv
Pharmaceutics, 2022 Janus kinase (JAK) inhibitors, such as tofacitinib (Xeljanz) and filgotinib (Jyseleca), have been approved for treatment of ulcerative colitis with several other JAK inhibitors in late-stage clinical trials for inflammatory bowel disease (IBD).
Vipul Yadav +16 more
doaj +1 more source
Pharmaceutics, 2023 This study investigates the complexation of mefloquine hydrochloride by cyclodextrins to improve its solubility in order to design an oral solution.
Amaury Durand +4 more
doaj +1 more source
Challenges of Colistin Use in ICU and Therapeutic Drug Monitoring: A Literature Review
Antibiotics, 2023 The emerging resistance of Gram-negative bacteria is a growing problem worldwide. Together with the financial cost, limited efficacy, and local unavailability of newer antibiotics or their combinations, it has led to the reintroduction of colistin as a ...
Jitka Rychlíčková +3 more
doaj +1 more source
MOF-Based Polymeric Nanocomposite Films as Potential Materials for Drug Delivery Devices in Ocular Therapeutics [PDF]
, 2021 Novel MOF-based polymer nanocomposite films were successfully prepared using Zr-based UiO-67 as a metal-organic framework (MOF) and polyurethane (PU) as a polymeric matrix. Synchrotron X-ray powder diffraction (SXRPD) analysis confirms the improved stability of the UiO-67 embedded nanocrystals and scanning electron microscopy images confirm their ...
arxiv +1 more source
MoleculesThe following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses.
Iwona Rykowska +3 more
doaj +1 more source
Extracellular stability of nanoparticulate drug carriers [PDF]
Archives of Pharmacal Research, 2013 Nanoparticulate (NP) drug carrier systems are attractive vehicles for selective drug delivery to solid tumors. Ideally, NPs should evade clearance by the reticuloendothelial system while maintaining the ability to interact with tumor cells and facilitate cellular uptake.
Karen C. Liu, Yoon Yeo, Yoon Yeo
openaire +3 more sources
Exploring kinase DFG loop conformational stability with AlphaFold2-RAVE [PDF]
arXiv, 2023 Kinases compose one of the largest fractions of the human proteome, and their misfunction is implicated in many diseases, in particular cancers. The ubiquitousness and structural similarities of kinases makes specific and effective drug design difficult. In particular, conformational variability due to the evolutionarily conserved DFG motif adopting in
arxiv