Results 21 to 30 of about 4,654,627 (208)

Ileocolonic-Targeted JAK Inhibitor: A Safer and More Effective Treatment for Inflammatory Bowel Disease

open access: yesPharmaceutics, 2022
Janus kinase (JAK) inhibitors, such as tofacitinib (Xeljanz) and filgotinib (Jyseleca), have been approved for treatment of ulcerative colitis with several other JAK inhibitors in late-stage clinical trials for inflammatory bowel disease (IBD).
Vipul Yadav   +16 more
doaj   +1 more source

Potencial hidrogeniônico de soluções de cloridrato de dobutamina expostas a condições ambientais de unidades de cuidados intensivos neonatais Hydrogen-ion potential of dobutamine hydrochloride solutions exposed to environmental conditions of neonatal intensive care units

open access: yesJornal de Pediatria, 2009
OBJETIVO: Verificar o potencial hidrogeniônico (pH) de soluções de cloridrato de dobutamina sob condições ambientais que mimetizam unidades de cuidados intensivos neonatais.
Lidiane L. Reis   +2 more
doaj   +1 more source

Review of binary, ternary and quaternary mixtures for induction and maintenance of opioid free anesthesia [PDF]

open access: yesFarmacia Hospitalaria, 2021
Objective: To describe and organize the current information available on binary, ternary and/or quaternary mixtures used in opioid-free anesthesia (OFA), as well as their physicochemical stability, in order to facilitate its correct administration ...
Beatriz Tauste-Hernández   +3 more
doaj   +1 more source

Challenges of Colistin Use in ICU and Therapeutic Drug Monitoring: A Literature Review

open access: yesAntibiotics, 2023
The emerging resistance of Gram-negative bacteria is a growing problem worldwide. Together with the financial cost, limited efficacy, and local unavailability of newer antibiotics or their combinations, it has led to the reintroduction of colistin as a ...
Jitka Rychlíčková   +3 more
doaj   +1 more source

Rapid Study on Mefloquine Hydrochloride Complexation with Hydroxypropyl-β-Cyclodextrin and Randomly Methylated β-Cyclodextrin: Phase Diagrams, Nuclear Magnetic Resonance Analysis, and Stability Assessment

open access: yesPharmaceutics, 2023
This study investigates the complexation of mefloquine hydrochloride by cyclodextrins to improve its solubility in order to design an oral solution.
Amaury Durand   +4 more
doaj   +1 more source

Analytical Techniques for the Assessment of Drug Stability

open access: yes, 2020
The expansion of the medications fetched an upheaval in the human healthcare system. These medicines would assist their role only when they do not have any contamination and being administered in the desired quantity.
Khan, Ajab   +17 more
core   +1 more source

Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery.

open access: yes, 2020
Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues
Beloqui Garcia, Ana   +7 more
core   +1 more source

Lignin-Based Spherical Structures and Their Use for Improvement of Cilazapril Stability in Solid State

open access: yesMolecules, 2020
Biopolymer-based spherical particles exhibit unique properties including narrow sizes and many functional groups on their surfaces. Therefore, they show great potential for application in many scientific and industrial processes.
Małgorzata Stanisz   +4 more
doaj   +1 more source

Drug-drug interactions in the hospital [PDF]

open access: yes, 2007
Introduction Drug interaction screening programs are an important tool to check prescriptions of multiple drugs for potential drug-drug interactions (pDDIs). Several programs are available on the market.
Vonbach, Priska
core   +1 more source

Anticancer Drugs: Recent Strategies to Improve Stability Profile, Pharmacokinetic and Pharmacodynamic Properties

open access: yesMolecules, 2022
In past decades, anticancer research has led to remarkable results despite many of the approved drugs still being characterized by high systemic toxicity mainly due to the lack of tumor selectivity and present pharmacokinetic drawbacks, including low ...
Giuseppina Ioele   +6 more
doaj   +1 more source

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