Results 21 to 30 of about 719,644 (307)

Challenges of Dissolution Methods Development for Soft Gelatin Capsules

Pharmaceutics, 2021
Recently, the development of soft gelatin capsules (SGCs) dosage forms has attracted a great deal of interest in the oral delivery of poorly water-soluble drugs.
Festo Damian, Mohammad Harati, Jeff Schwartzenhauer, Owen Van Cauwenberghe, Shawn D. Wettig   +4 more
doaj   +1 more source

Stability of Antimicrobial Drug Molecules in Different Gravitational and Radiation Conditions in View of Applications during Outer Space Missions

Molecules, 2021
The evolution of different antimicrobial drugs in terrestrial, microgravity and hypergravity conditions is presented within this review, in connection with their implementation during human space exploration.
Ágota Simon, Adriana Smarandache, Vicentiu Iancu, Mihail Lucian Pascu   +3 more
doaj   +1 more source

Anticancer Drugs: Recent Strategies to Improve Stability Profile, Pharmacokinetic and Pharmacodynamic Properties

Molecules, 2022
In past decades, anticancer research has led to remarkable results despite many of the approved drugs still being characterized by high systemic toxicity mainly due to the lack of tumor selectivity and present pharmacokinetic drawbacks, including low ...
Giuseppina Ioele, Martina Chieffallo, Maria Antonietta Occhiuzzi, Michele De Luca, Antonio Garofalo, Gaetano Ragno, Fedora Grande   +6 more
doaj   +1 more source

Stability Studies of Vaccines

, 2020
Edward Jenner laid the foundation of vaccination as he was the first to introduce and use the procedure as well as pursued his scientific investigation against the deadly smallpox.
Khan, Ajab, Muhammad Asim Farooq, Anam Ahsan, Baig, Mirza Muhammad Faran Ashraf, Aslam, Qurat-ul-ain, Aslam, Qurat Ul Ain, Farooq, Muhammad Asim, Qurat-ul-ain Aslam, Ajab Khan, Mirza Muhammad Faran Ashraf Baig, Ahsan, Anam   +10 more
core   +1 more source

Relative Stability of Pyrazinamide Polymorphs Revisited: A Computational Study of Bending and Brittle Forms Phase Transitions in a Broad Temperature Range

Crystals, 2023
Pyrazinamide may exist in at least four known polymorphic forms, which were obtained experimentally. One of these polymorphs, (α), shows outstanding mechanical properties, demonstrating a significant anisotropic plasticity in a three-point bending test ...
Aleksandr S. Dubok, Denis A. Rychkov
doaj   +1 more source

Machine Learning Predicts Drug Metabolism and Bioaccumulation by Intestinal Microbiota

Pharmaceutics, 2021
Over 150 drugs are currently recognised as being susceptible to metabolism or bioaccumulation (together described as depletion) by gastrointestinal microorganisms; however, the true number is likely higher.
Laura E. McCoubrey, Stavriani Thomaidou, Moe Elbadawi, Simon Gaisford, Mine Orlu, Abdul W. Basit   +5 more
doaj   +1 more source

Forced degradation studies to identify organic impurities in pharmaceuticals: a Brazilian perspective

Revista de Ciências Farmacêuticas Básica e Aplicada, 2021
Objective: The aim of this study was to highlight and sediment the necessary steps to be followed while conducting forced degradation studies to identify degradation products and to describe the Brazilian and international regulations associated with ...
Fernanda Fernandes Farias, Valéria Adriana Pereira Martins, Helena Miyoco Yano, Luz Marina Trujillo, Ernani Pinto   +4 more
doaj  

Stability investigation of total parenteral nutrition admixture prepared in a hospital pharmacy [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. In the cases when nutrition of patients can not be orally nor enterally performed, parenteral nutrition is a method of the therapy that provides more successful and rapid recovery. In that way, hospitalization can be significantly shorter,
Mirković Dušica, Antunović Mirjana, Putić Vesna, Aleksić Dragana   +3 more
doaj   +1 more source

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Nature Communications
The Greatwall kinase inhibits PP2A-B55 phosphatase activity during mitosis to stabilise critical Cdk1-driven mitotic phosphorylation. Although Greatwall represents a potential oncogene and prospective therapeutic target, our understanding of the cellular
Róbert Zach, Michael Annis, Sandra M. Martin-Guerrero, Abdulrahman Alatawi, Kim Hou Chia, Megan Meredith, Kay Osborn, Nisha Peter, William Pearce, Jessica Booth, Mohan Rajasekaran, Samantha Dias, Lily Coleman-Evans, William R. Foster, Jon A. Harper, Alex D. Herbert, Catherine Tighe, Tristan Reuillon, Ryan West, Oliver Busby, Kamila Burdova, Damien Crepin, Sergi Ortoll, Kulthida Vaeteewoottacharn, Donniphat Dejsuphong, John Spencer, Hitesh Patel, Darren Le Grand, Thomas A. Hunt, David M. Andrews, Hiroyuki Yamano, Pedro R. Cutillas, Antony W. Oliver, Simon E. Ward, Helfrid Hochegger   +34 more
doaj   +1 more source

Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review

Molecules
The following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses.
Iwona Rykowska, Ola Michałkiewicz, Iwona Nowak, Rafał Nowak   +3 more
doaj   +1 more source