Results 21 to 30 of about 1,390,034 (354)

Challenges of Colistin Use in ICU and Therapeutic Drug Monitoring: A Literature Review

Antibiotics, 2023
The emerging resistance of Gram-negative bacteria is a growing problem worldwide. Together with the financial cost, limited efficacy, and local unavailability of newer antibiotics or their combinations, it has led to the reintroduction of colistin as a ...
Jitka Rychlíčková, Vendula Kubíčková, Pavel Suk, Karel Urbánek   +3 more
doaj   +1 more source

Adaptive HIV-1 evolutionary trajectories are constrained by protein stability [PDF]

, 2017
Despite the use of combination antiretroviral drugs for the treatment of HIV-1 infection, the emergence of drug resistance remains a problem. Resistance may be conferred either by a single mutation or a concerted set of mutations.
Kandathil, Shaun M., Lovell, Simon C., Olabode, Abayomi S., Robertson, David L.   +3 more
core   +2 more sources

Rapid Study on Mefloquine Hydrochloride Complexation with Hydroxypropyl-β-Cyclodextrin and Randomly Methylated β-Cyclodextrin: Phase Diagrams, Nuclear Magnetic Resonance Analysis, and Stability Assessment

Pharmaceutics, 2023
This study investigates the complexation of mefloquine hydrochloride by cyclodextrins to improve its solubility in order to design an oral solution.
Amaury Durand, David Mathiron, Sébastien Rigaud, Florence Djedaini-Pilard, Frédéric Marçon   +4 more
doaj   +1 more source

Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter pylori [PDF]

, 2015
Objectives: There are various obstacles in the eradication of Helicobacter.pylori (H. pylori) infections, including low antibiotic levels and poor accessibility of the drug at the site of the infection.
Adebisi, Adebisi, Adeola O. Adebisi, Ahuja, Akiyama, Bai, Bajpai, Barbara R. Conway, Batchelor, Bazzoli, Boddupalli, Cammarota, Castro, Chun, Desai, Dunn, Dupuy, Erah, Erah, Ernst, Gal, Georgopoulos, Gåserød, Higuchi, Hixson, Iijima, Ikeda, Ishak, Kawahara, Khanvilkar, Kohri, Korsmeyer, Lee, Lehmann, Malfertheiner, Miyazaki, Moore, Murata, Murray, Najib, Nakagawa, Nayak, Norris, Park, Pasparakis, Pereira, Peter R. Laity, Peterson, Rajinikanth, Romero, Rothenbacher, Singh, Smrdel, Stops, Suerbaum, Suzuki, Umamaheshwari, Varum, Whitehead, Østberg   +59 more
core   +1 more source

Depth of anesthesia control using internal model control techniques [PDF]

, 2010
The major difficulty in the design of closed-loop control during anaesthesia is the inherent patient variability due to differences in demographic and drug tolerance.
Anna, Shahab, Wen, Peng
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Lignin-Based Spherical Structures and Their Use for Improvement of Cilazapril Stability in Solid State

Molecules, 2020
Biopolymer-based spherical particles exhibit unique properties including narrow sizes and many functional groups on their surfaces. Therefore, they show great potential for application in many scientific and industrial processes.
Małgorzata Stanisz, Łukasz Klapiszewski, Dariusz T. Mlynarczyk, Beata J. Stanisz, Teofil Jesionowski   +4 more
doaj   +1 more source

A systematic approach to the formulation of anti-onychomycotic nail patches [PDF]

, 2018
Nail patches have a potential role as drug carriers for the topical treatment of nail diseases such as onychomycosis, a common condition. O ur aim was therefore to develop a systematic and novel appr oach to the formulat ion of a simple drug -in-adhesive
Charalambides, MN, Kinloch, AJ, Mohammed, IK, Murdan, K, Rizi, K, Xu, K   +5 more
core   +1 more source

Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release [PDF]

, 2011
Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug ...
A Al-Omar, A Latrofa, A Miro, A Trapani, A Vyas, AC Jain, AK Upadhyay, AL Nielsen, AS Hoffman, B Haeberlin, B Pose-Vilarnovo, BN Naidu, C Cannavà, C Rodriguez-Tenreiro, C Rupp, C-Y Chen, Catarina Carvalho, Claúdia Conduto, CM Buchanan, CM Fernandes, D Duchêne, D Duchêne, EA Zannou, EY Kim, F Frézard, F Hirayama, G Corti, G Gladys, G Pescitelli, G Trapani, G Wenz, G Zingone, GL Amidon, H Blode, H Hamada, H Matsuda, H Namazi, H Taira, H Yano, HA Archontaki, Helena M. Cabral Marques, HH Sigurdsson, HS Ganapathy, HS Woldum, Inês Sanches, IV Terekhova, J Cheng, J Králová, J Savolainen, J Szejtli, J Szejtli, J Xiong, JJ García-Rodriguez, João Arrais, JP Venter, JR Moyano, JS Smith, JW Wong, K Dua, K Minami, K Motoyama, K Nakanishi, K Okimoto, K Okimoto, K Okimoto, K Terao, K Udo, K Uekama, K Uekama, K Uekama, K-H Frӧmming, KP Chowdary, L Ribeiro, L Szente, L Trichard, M Agüeros, M Agüeros, M Charoenchaitrakool, M Cirri, M Echezarreta-López, M Fukuda, M Jug, M Jug, M Kamada, M Prabaharan, M Roux, M Sauceau, M Temtem, M Türk, M Usuda, M Yoshinari, M-J Zou, ME Zugasti, MT Esclusa-Díaz, MZI Khan, N Mourtzis, N Patel, N Zerrouk, N Zhang, N Özdemir, P Jansook, P Mura, P Mura, P Mura, P Mura, P Mura, Patrícia Pontes, Paulo José Salústio, PJ Salústio, R Cavalli, R Cavalli, R Challa, R Ficarra, R Garg, R Stancanelli, RL Carrier, S Petralito, S Péroche, S Sajeesh, S Sotthivirat, S Sotthivirat, S Szejtli, S Tommasini, S-Y Lee, Shishu, SM Badr-Eldin, T Endo, T Higashi, T Higashi, T Irie, T Loftsson, T Loftsson, T Loftsson, T Vasconcelos, T Yamanoi, V Burckbuchler, V Lemesle-Lamache, VM Rao, W Ling, W Sajomsang, X Lu, X Wen, X-M Liu, Y He, Y Ikeda, Y Ikeda, Y Liu, Y Liu, Y Lu, Y Tozuka, Y Zhou, Y-Z Du, Z Lu, Z Wang   +153 more
core   +1 more source

Anticancer Drugs: Recent Strategies to Improve Stability Profile, Pharmacokinetic and Pharmacodynamic Properties

Molecules, 2022
In past decades, anticancer research has led to remarkable results despite many of the approved drugs still being characterized by high systemic toxicity mainly due to the lack of tumor selectivity and present pharmacokinetic drawbacks, including low ...
Giuseppina Ioele, Martina Chieffallo, Maria Antonietta Occhiuzzi, Michele De Luca, Antonio Garofalo, Gaetano Ragno, Fedora Grande   +6 more
doaj   +1 more source

Drugs, Crime, Space, and Time: A Spatiotemporal Examination of Drug Activity and Crime Rates [PDF]

, 2020
To take stock of the “neighborhood effects” of drug activity, we combined theoretical insights from the drugs and crime and communities and place literatures in examining the longitudinal relationship between drug activity and crime rates at more ...
Contreras, C, Hipp, JR
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