A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. [PDF]
, 2015 Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain.
Caddick, S +5 more
core +1 more source
EVALUATION OF THE STABILITY OF VIGABATRIN IN HOSPITALAR EXTEMPORANEOUS FORMULATIONS
Drug Analytical Research, 2019 The aim of this study was to analyze the chemical stability of the anticonvulsant vigabatrin extemporaneous formulation from tablets in storage conditions of different temperatures and types of packaging used.
Marcio Vinicius Ayres +4 more
doaj +1 more source
Molecular Dynamics Studies on HIV-1 Protease: Drug Resistance and Folding Pathways [PDF]
, 2001 Drug resistance to HIV-1 Protease involves accumulation of multiple mutations in the protein. Here we investigate the role of these mutations by using molecular dynamics simulations which exploit the influence of the native-state topology in the folding ...
Carloni, Paolo +3 more
core +2 more sources
Crystals, 2023 Pyrazinamide may exist in at least four known polymorphic forms, which were obtained experimentally. One of these polymorphs, (α), shows outstanding mechanical properties, demonstrating a significant anisotropic plasticity in a three-point bending test ...
Aleksandr S. Dubok, Denis A. Rychkov
doaj +1 more source
The stability analyses of the mathematical models of hepatitis C virus infection [PDF]
, 2015 There are two mathematical models of Hepatitis C virus (HCV) being discussed; the original model of HCV viral dynamics (Neumann et al., 1998) and its extended model (Dahari et al., 2007). The key aspects of the mathematical models have provided resources
Chong, Maureen Siew Fang +3 more
core +1 more source
Machine Learning Predicts Drug Metabolism and Bioaccumulation by Intestinal Microbiota
Pharmaceutics, 2021 Over 150 drugs are currently recognised as being susceptible to metabolism or bioaccumulation (together described as depletion) by gastrointestinal microorganisms; however, the true number is likely higher.
Laura E. McCoubrey +5 more
doaj +1 more source
Development of a predictive model for the long term stability assessment of drug-in-adhesive transdermal films using polar pressure sensitive adhesives as carrier/matrix. [PDF]
, 2017 Drug crystallization in transdermal drug delivery systems is a critical quality defect. The impact of drug load and hydration on the physical stability of polar (acrylic) drug-in-adhesive (DIA) films was investigated with the objective to identify ...
Ashton, Mark +4 more
core +1 more source
Stability investigation of total parenteral nutrition admixture prepared in a hospital pharmacy [PDF]
Vojnosanitetski Pregled, 2008 Background/Aim. In the cases when nutrition of patients can not be orally nor enterally performed, parenteral nutrition is a method of the therapy that provides more successful and rapid recovery. In that way, hospitalization can be significantly shorter,
Mirković Dušica +3 more
doaj +1 more source
Nature CommunicationsThe Greatwall kinase inhibits PP2A-B55 phosphatase activity during mitosis to stabilise critical Cdk1-driven mitotic phosphorylation. Although Greatwall represents a potential oncogene and prospective therapeutic target, our understanding of the cellular
Róbert Zach +34 more
doaj +1 more source
The Effectiveness of Intravenous Admixture Training in a Private Hospital in Surabaya [PDF]
, 2012 In this hospital, the nurses face intravenous (iv) admixture problems in preparing and delivering iv injection and/or infusion to patients due to their limited background knowledge of drug stability and incompatibility.
Herawati, Fauna
core