Results 11 to 20 of about 4,907,325 (259)

Cistracurium Besylate 10 mg/mL Solution Compounded in a Hospital Pharmacy to Prevent Drug Shortages: A Stability Study Involving Four Degradation Products

Pharmaceutics, 2023
Background: Stability study of a 10 mg/mL injectable cisatracurium solution stored refrigerated in amber glass ampoules for 18 months (M18). Methods: 4000 ampoules were aseptically compounded using European Pharmacopoeia (EP)-grade cisatracurium besylate,
Marine Roche, Cécile Danel, Nicolas Simon, Mostafa Kouach, Myriam Bouchfaa, Christophe Berneron, Pascal Odou, Damien Lannoy   +7 more
doaj   +1 more source

Challenges of Dissolution Methods Development for Soft Gelatin Capsules

Pharmaceutics, 2021
Recently, the development of soft gelatin capsules (SGCs) dosage forms has attracted a great deal of interest in the oral delivery of poorly water-soluble drugs.
Festo Damian, Mohammad Harati, Jeff Schwartzenhauer, Owen Van Cauwenberghe, Shawn D. Wettig   +4 more
doaj   +1 more source

Stability of Antimicrobial Drug Molecules in Different Gravitational and Radiation Conditions in View of Applications during Outer Space Missions

Molecules, 2021
The evolution of different antimicrobial drugs in terrestrial, microgravity and hypergravity conditions is presented within this review, in connection with their implementation during human space exploration.
Ágota Simon, Adriana Smarandache, Vicentiu Iancu, Mihail Lucian Pascu   +3 more
doaj   +1 more source

Potencial hidrogeniônico de soluções de cloridrato de dobutamina expostas a condições ambientais de unidades de cuidados intensivos neonatais Hydrogen-ion potential of dobutamine hydrochloride solutions exposed to environmental conditions of neonatal intensive care units

Jornal de Pediatria, 2009
OBJETIVO: Verificar o potencial hidrogeniônico (pH) de soluções de cloridrato de dobutamina sob condições ambientais que mimetizam unidades de cuidados intensivos neonatais.
Lidiane L. Reis, Maria Angélica S. Peterlini, Mavilde L. G. Pedreira   +2 more
doaj   +1 more source

Ileocolonic-Targeted JAK Inhibitor: A Safer and More Effective Treatment for Inflammatory Bowel Disease

Pharmaceutics, 2022
Janus kinase (JAK) inhibitors, such as tofacitinib (Xeljanz) and filgotinib (Jyseleca), have been approved for treatment of ulcerative colitis with several other JAK inhibitors in late-stage clinical trials for inflammatory bowel disease (IBD).
Vipul Yadav, Aileen House, Silvia Matiz, Laura E. McCoubrey, Kimberly A. Bettano, Leena Bhave, Meiyao Wang, Peter Fan, Siqun Zhou, Janice D. Woodhouse, Eirini Poimenidou, Liu Dou, Abdul W. Basit, Lily Y. Moy, Robert Saklatvala, Laxminarayan G. Hegde, Hongshi Yu   +16 more
doaj   +1 more source

Analytical Techniques for the Assessment of Drug Stability

, 2020
The expansion of the medications fetched an upheaval in the human healthcare system. These medicines would assist their role only when they do not have any contamination and being administered in the desired quantity.
Khan, Ajab, Muhammad Asim Farooq, Dickson Pius Wande, Wen-xia Tian, Baig, Mirza Muhammad Faran Ashraf, Aslam, Qurat-ul-ain, Qurat Ul Ain, Wande, Dickson Pius, Ain, Qurat Ul, Anam Ahsan, Tian, Wen Xia, Aslam, Qurat Ul Ain, Farooq, Muhammad Asim, Tian, Wen-xia, Qurat-ul-ain Aslam, Ajab Khan, Mirza Muhammad Faran Ashraf Baig, Ahsan, Anam   +17 more
core   +1 more source

Review of binary, ternary and quaternary mixtures for induction and maintenance of opioid free anesthesia [PDF]

Farmacia Hospitalaria, 2021
Objective: To describe and organize the current information available on binary, ternary and/or quaternary mixtures used in opioid-free anesthesia (OFA), as well as their physicochemical stability, in order to facilitate its correct administration ...
Beatriz Tauste-Hernández, Manuel Cortiñas-Sáenz, Francisco Dámaso Fernández-Ginés, Juan Miguel Expósito-López   +3 more
doaj   +1 more source

Challenges of Colistin Use in ICU and Therapeutic Drug Monitoring: A Literature Review

Antibiotics, 2023
The emerging resistance of Gram-negative bacteria is a growing problem worldwide. Together with the financial cost, limited efficacy, and local unavailability of newer antibiotics or their combinations, it has led to the reintroduction of colistin as a ...
Jitka Rychlíčková, Vendula Kubíčková, Pavel Suk, Karel Urbánek   +3 more
doaj   +1 more source

Rapid Study on Mefloquine Hydrochloride Complexation with Hydroxypropyl-β-Cyclodextrin and Randomly Methylated β-Cyclodextrin: Phase Diagrams, Nuclear Magnetic Resonance Analysis, and Stability Assessment

Pharmaceutics, 2023
This study investigates the complexation of mefloquine hydrochloride by cyclodextrins to improve its solubility in order to design an oral solution.
Amaury Durand, David Mathiron, Sébastien Rigaud, Florence Djedaini-Pilard, Frédéric Marçon   +4 more
doaj   +1 more source

Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery.

, 2020
Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues
Beloqui Garcia, Ana, Memvanga, Patrick, Aristote B. Buya, Véronique Préat, Buya, Aristote Banzenga, Ana Beloqui, Préat, Véronique, Patrick B. Memvanga   +7 more
core   +1 more source