Results 71 to 80 of about 7,888,866 (398)

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Nature Communications
The Greatwall kinase inhibits PP2A-B55 phosphatase activity during mitosis to stabilise critical Cdk1-driven mitotic phosphorylation. Although Greatwall represents a potential oncogene and prospective therapeutic target, our understanding of the cellular
Róbert Zach, Michael Annis, Sandra M. Martin-Guerrero, Abdulrahman Alatawi, Kim Hou Chia, Megan Meredith, Kay Osborn, Nisha Peter, William Pearce, Jessica Booth, Mohan Rajasekaran, Samantha Dias, Lily Coleman-Evans, William R. Foster, Jon A. Harper, Alex D. Herbert, Catherine Tighe, Tristan Reuillon, Ryan West, Oliver Busby, Kamila Burdova, Damien Crepin, Sergi Ortoll, Kulthida Vaeteewoottacharn, Donniphat Dejsuphong, John Spencer, Hitesh Patel, Darren Le Grand, Thomas A. Hunt, David M. Andrews, Hiroyuki Yamano, Pedro R. Cutillas, Antony W. Oliver, Simon E. Ward, Helfrid Hochegger   +34 more
doaj   +1 more source

The Effectiveness of Intravenous Admixture Training in a Private Hospital in Surabaya [PDF]

, 2012
In this hospital, the nurses face intravenous (iv) admixture problems in preparing and delivering iv injection and/or infusion to patients due to their limited background knowledge of drug stability and incompatibility.
Herawati, Fauna
core  

Solid lipid dispersion of calcitriol with enhanced dissolution and stability [PDF]

, 2011
Solid dispersion of calcitriol with lipophilic surfactants and triglycerides was developed by melt-mixing method to modify the release and enhance stability of the drug. The solid dispersions were characterized by differential scanning calorimetry (DSC),
Yuan, Ting, Qin, Lingzhen, Wang, Zhouhua, Nie, Jinyuan, Guo, Zhefei, Li, Ge, Wu, Chuanbin   +6 more
core   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review

Molecules
The following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses.
Iwona Rykowska, Ola Michałkiewicz, Iwona Nowak, Rafał Nowak   +3 more
doaj   +1 more source

Rapid Study on Mefloquine Hydrochloride Complexation with Hydroxypropyl-β-Cyclodextrin and Randomly Methylated β-Cyclodextrin: Phase Diagrams, Nuclear Magnetic Resonance Analysis, and Stability Assessment

Pharmaceutics, 2023
This study investigates the complexation of mefloquine hydrochloride by cyclodextrins to improve its solubility in order to design an oral solution.
Amaury Durand, David Mathiron, Sébastien Rigaud, Florence Djedaini-Pilard, Frédéric Marçon   +4 more
doaj   +1 more source

Sol–gel synthesis and thermal behavior of bioactive ferrous citrate–silica hybrid materials [PDF]

, 2018
Imbalance of the iron level in the body causes several diseases. In particular, the low level of iron, during pregnancy, is responsible for the iron deficiency anemia, and even of neurodegenerative diseases.
Catauro, M., Naviglio, D., Risoluti, R., Vecchio, Ciprioti   +3 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Albumin nanoparticles for glutathione-responsive release of cisplatin: new opportunities for medulloblastoma treatment [PDF]

, 2016
Redox-responsive nanoparticles were synthesized by desolvation of bovine serum albumin followed by disulfide-bond crosslinking with N, Nʹ-Bis (acryloyl) cystamine. Dynamic light scattering and transmission electron microscopy studies revealed spherical
Abballe, Luana, Besharat, ZEIN MERSINI, Catanzaro, Giuseppina, Cirillo, Giuseppe, Curcio, Manuela, Ferretti, Elisabetta, Iemma, Francesca, Picci, Nevio, Spizzirri, Umile Gianfranco, Vacca, Alessandra   +9 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source