Results 61 to 70 of about 308,940 (263)

Дослідження стабільності м´якого препарату для нашкірного застосування «Пробіоскін» у процесі зберігання

open access: yesAnnals of Mechnikov's Institute, 2021
Introduction. Currently, there are no means for the treatment of dermatological diseases in the domestic pharmaceutical market with the simultaneous correction and maintenance of the skin microbiome.
Alina Solovyova, Olga Kaliuzhnaia
doaj  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Effect of Temperature on the Stability and Release Profile of Ibuprofen Microcapsules

open access: yesIraqi Journal of Pharmaceutical Sciences, 2017
The stability and releasing profile of 2:1 core: wall ratio ibuprofen microcapsules prepared by aqueous coacervation (gelatin and acacia polymers coat) and an organic coacervation methods (ethyl cellulose and sodium alginate polymers coat) in weight ...
Issraa R. Abed Al- Rahman
doaj   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Study on Drug Usage, Storage and Wastage among Households in Chengalpattu, Tamil Nadu, India - A Cross-Sectional Study

open access: yesNational Journal of Community Medicine
Background: Improper drug storage is immensely prevalent in households. A significant number of families do not follow prescribed practices for maintaining the safety and efficacy of medications.
Nancy L   +4 more
doaj   +1 more source

Drug storage, polypharmacy and frailty syndrome in older people: an observational study. [PDF]

open access: yesPan Afr Med J, 2023
Tabué-Téguo M   +8 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Awareness of home drug storage and utilization habits: Saudi study

open access: yesMedicine Science, 2018
The aim of the study was to investigate the awareness of residents in Saudi Arabia toward in-home drug storage and the using habits of their medications.
Marwa Ibrahim Koshok   +6 more
doaj   +1 more source

Review of Drug Storage Conditions, A Case Report. [PDF]

open access: yesHosp Pharm, 2023
Tejedor Tejada E   +2 more
europepmc   +1 more source

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