Results 91 to 100 of about 1,947,705 (257)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Obstruction of Synergism

, 2019
Working Paper on Synergism and One-Size-Fits-All ...
David C. Norris
core   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Ohio BWC Drug-Free EZ Program : technical assistance manual : reference/resource guide

, 2002
Title from title screen (viewed Sept. 24, 2004).; "BWC-7648 (Rev. 7/18/2002)"--Screen 87 (i.e. p. 1 of form: Progress report, Drug-Free Workplace/Drug-Free EZ Program).; Electronic text (pdf, 89 p.).; Harvested from the web on 9/24 ...
Drug-Free EZ Program (Ohio. Bureau of Workers' Compensation)
core  

Additional file 14: Figure S7. of Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells

, 2017
Drug combination effect reanalyzed using delta score for the combination matrix data shown in Fig. 7 and Fig. S5. Values less than zero represent antagonism (green color) and greater than zero represent synergism (red color).
Sawan Kumar Jha (3763693), Bhagwan Yadav (458005), Prson Gautam (1545520), Tero Aittokallio (61010), Leena Karhinen (458003), Krister Wennerberg (458006), Agnieszka Szwajda (458004)   +6 more
core   +1 more source

Broad synergistic antiviral efficacy between a novel elite controller-derived dipeptide and antiretrovirals against drug-resistant HIV-1

Frontiers in Cellular and Infection Microbiology
IntroductionThe naturally occurring dipeptide Tryptophylglycine (WG) is enhanced in human immunodeficiency virus (HIV-1) infected Elite Controllers (EC).
Federica Giammarino, Anders Sönnerborg, Anders Sönnerborg, Anders Sönnerborg, Rafael Ceña-Diez   +4 more
doaj   +1 more source

Drug Synergism of Anticancer Action in Combination with Favipiravir and Paclitaxel on Neuroblastoma Cells. [PDF]

Medicina (Kaunas), 2023
Turkez H, Arslan ME, Selvitopi H, Kadi A, Oner S, Mardinoglu A.   +5 more
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

, 2018
International audiencePotentiation of hostile monoclonal antibodies (mAb) by chemotherapeutic agents constitutes a valuable strategy for designing effective and safer therapy against cancer.
Ben Mostefa Daho, Mohamed, Bahri, Meriem, Fleurence, Julien, Fougeray, Sophie, Birklé, Stéphane, Faraj, Sébastien   +5 more
core   +1 more source