Results 111 to 120 of about 82,422 (345)

Experimental pharmacological research regarding the antidepressant effect of associating doxepin and selegiline in normal mice [PDF]

, 2019
The severity and complexity of depression can vary widely among individuals, thus making single drug therapy ineffective in some cases. Taking this fact into account and using a mouse model, we set on investigating the possibility of obtaining a ...
Chiriță, Cornel, Dănciulescu Miulescu, Rucsandra E, Limban, Carmen, Marineci, Cristina D, Mireșan, Horațiu, Negreș, Simona, Nuță, Diana C, Zbârcea, Cristina E, Ștefănescu, Emil   +8 more
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Broad synergistic antiviral efficacy between a novel elite controller-derived dipeptide and antiretrovirals against drug-resistant HIV-1

Frontiers in Cellular and Infection Microbiology
IntroductionThe naturally occurring dipeptide Tryptophylglycine (WG) is enhanced in human immunodeficiency virus (HIV-1) infected Elite Controllers (EC).
Federica Giammarino, Anders Sönnerborg, Anders Sönnerborg, Anders Sönnerborg, Rafael Ceña-Diez   +4 more
doaj   +1 more source

The synergistic effect between positivity, socio-demographic factors and smoking cessation: results of a cohort study [PDF]

, 2018
OBJECTIVE: To examine the extent to which a effect does exist between Positivity (POS), smoking and socio-demographic factors in determining quitting smoking in subjects participating in a Group Counselling Program (GCP) for smoking cessation.METHODS ...
Alessandri, G., Caprara, G. V., Ceccanti, M., Enea, D., Grassi, M. C., La Torre, G., Milioni, M., Pasquariello, S.   +7 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Drug Synergism of Anticancer Action in Combination with Favipiravir and Paclitaxel on Neuroblastoma Cells. [PDF]

Medicina (Kaunas), 2023
Turkez H, Arslan ME, Selvitopi H, Kadi A, Oner S, Mardinoglu A.   +5 more
europepmc   +1 more source

In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine. [PDF]

, 2005
Highly active antiretroviral therapy has substantially improved prognosis in human immunodeficiency virus (HIV). However, the integration of proviral DNA, development of viral resistance, and lack of permeability of drugs into sanctuary sites (e.g ...
Back, DJ, Bray, PG, Chandler, B, Hart, CA, Hartkoorn, RC, Janneh, O, Khoo, SH, Martin, P, Owen, A, Ward, SA   +9 more
core   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review

Frontiers in Toxicology
BackgroundWhile excessive oral intake of clozapine is known to cause severe complications, this case report highlights that even conventional doses of clozapine ingested after alcohol consumption–without reaching toxic concentrations–can lead to the rare
Wenzhen Zhou, Yuxin Sun, Mingcheng Dai, Senlin Ma, Qiuxin Lu, Junwei Qian, Zhaoming Shang, Kangshuai Zhou, Mingquan Chen, Mingquan Chen, Xiaofei Jiang   +10 more
doaj   +1 more source

Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test [PDF]

, 2012
The genotoxicity of quinolone and fluroquinolones was assessed using the micronucleus (MN) test on Viciafaba roots by direct contact exposure to a solid matrix.
Bousquet-Mélou, Alain, Guiresse, Agnès Maritchù, Hafidi, Mohamed, Hamdi, Hassan, Khadra, Ahmed, Lacroix, Marlene Z., Merlina, Georges, Pinelli, Eric   +7 more
core   +3 more sources