Results 261 to 270 of about 82,521 (353)

Host niche-specific challenges hindering the treatment of polymicrobial infections. [PDF]

J Bacteriol
Black C, Wakeman CA.
europepmc   +1 more source

A Novel Microfluidic System for 3D Epidermis and Full‐Thickness Skin Growth for Nanoparticle Safety Assessment

Advanced Healthcare Materials, EarlyView.
This work presents a novel, dynamically perfused, configurable microfluidic system for epidermis‐only (E and full‐thickness skin (FT SoC) growth, emulating human skin structure and barrier function. Upon TiO2 nanoparticle exposure, the system reveals compromised barrier integrity, reduced metabolic activity, increased permeability, and chemokine‐driven
Samantha Costa, Ana B. Carneiro, Filipa Lebre, João Meneses, Alar Ainla, Cacilda Moura, Ernesto Alfaro‐Moreno, Ana R. Ribeiro   +7 more
wiley   +1 more source

Preclinical Investigation of PLGA Nanocapsules and Nanostructured Lipid Carriers for Organoselenium Delivery: Comparative In Vitro Toxicological Profile and Anticancer Insights. [PDF]

Pharmaceutics
Maia-do-Amaral BC, Pieta TB, Zanon LF, Carneosso GC, Nascimento LP, Rocha NS, do Nascimento BF, Macedo LB, de Almeida TM, Rodrigues OED, Schaffazick SR, Rolim CMB, Nogueira-Librelotto DR.   +12 more
europepmc   +1 more source

Beyond Nanoparticle‐Based Intracellular Drug Delivery: Cytosol/Organelle‐Targeted Drug Release and Therapeutic Synergism [PDF]

Hana Cho, Kang Moo Huh, Min Suk Shim, Yong‐Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang   +6 more
openalex   +1 more source

Metallofullerenol Sc3N@C80(OH)18: A New Generation Radioprotector Protecting Human Erythrocytes Against Multiple Biochemical Damage Modes Upon Gamma Irradiation, Identifying It as a Scavenger of Short‐ and Long‐Lived Radicals

Advanced Healthcare Materials, EarlyView.
Metallofullerenol Sc3N@C80(OH)18 demonstrates strong radioprotective properties as a scavenger of both short‐ and long‐lived radicals. The study reveals protection of human erythrocytes from γ‐radiation–induced biochemical damage via post‐irradiation removal of primary and secondary reactive oxidants, supported by pulse radiolysis kinetics.
Jacek Grebowski, Maciej Studzian, Szymon Lekki‐Porebski, Anna Konarska, Marian Wolszczak, Grzegorz Litwinienko, Lukasz Pulaski   +6 more
wiley   +1 more source

Phytochemical composition and synergistic antimicrobial effects of <i>Rosmarinus officinalis</i> essential oils during flowering in an arid mediterranean region. [PDF]

AIMS Microbiol
Abbad I, Soulaimani B, El Hakioui I, El Baz S, Varoni EM, Iriti M.   +5 more
europepmc   +1 more source

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

Advanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin, Wenbing Jiang, Kai Xin Thong, Zeynep Ulker, Brihitejas Patel, Cynthia Yu‐Wai‐Man   +5 more
wiley   +1 more source

TEST FOR SYNERGISM BETWEEN 2-DRUGS

, 2016
Darby, S, Ellis, M
openaire   +1 more source

Inhibitory effects of FK506 in combination with CsA on human lymphocyte alloproliferative responses [PDF]

, 1989
Duquesnoy, RJ, Eiras, G, Makowka, L, Starzl, TE, Todo, S, Zeevi, A   +5 more
core  

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source