Results 241 to 250 of about 1,947,705 (257)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Mechanistic Evaluation of LolA and <i>β</i>-Sliding Clamp Inhibition by Silybin and Diclofenac as Gentamicin Adjuvants Against Enteropathogenic <i>Escherichia coli</i>. [PDF]

Int J Microbiol
Rafi RH, Haque A, Tawfiq MJ, Barai C, Khan MRI, Faruqe MO, Shoily MSA, Al-Bari MAA.   +7 more
europepmc   +1 more source

Preclinical characterization of HEC116094, an oral inhibitor of the influenza A virus polymerase PB2 subunit. [PDF]

Emerg Microbes Infect
Nie L, Chen Y, Wang P, Xie Y, Zuo Y, Zhang Y, Gu B, Lin K, Li J, Zhang L.   +9 more
europepmc   +1 more source

A nickel N-heterocyclic biscarbene complex derived from caffeine enhances fluconazole efficacy against <i>Nakaseomyces glabratus</i>. [PDF]

Microbiol Spectr
Malta-Luís C, Romeo G, Francescato G, Mariano C, Mil-Homens D, Petronilho A, Pimentel C.   +6 more
europepmc   +1 more source

F2F-202, a Selective Histone Deacetylase 6 (HDAC6) Inhibitor, Behaves as an Arrow with Multiple Tips against Azole-Resistant <i>C. albicans</i>: Modulation of Yeast-to-Hyphae Transition, Trailing Effect, and Oxidative Stress. [PDF]

ACS Infect Dis
Barone S, Mateu B, Piccolo M, Guadagni A, Irace C, Lembo F, Summa V, Buommino E, Brindisi M.   +8 more
europepmc   +1 more source

From cell lines to PDXs: in vivo confirmation of synergistic drug responses identified in leukemia cell line models. [PDF]

Blood Neoplasia
Verbeek TCAI, Vrenken KS, Arentsen-Peters STCJM, van den Hoof E, Pieters R, Stam RW.   +5 more
europepmc   +1 more source

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Development and validation of a general approach to predict and quantify the synergism of anti-cancer drugs using experimental design and artificial neural networks

Talanta, 2013
Tiziana Pivetta, Alessandra Pani, Filippo Amato   +2 more
exaly