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A Fatality Due to Drug Synergism
Medicine, Science and the Law, 1982Thioridazine is a phenothiazine tranquillizer with specificity for psychotherapeutic action. It is well tolerated but will induce changes in myocardial repolarization which are further aggravated in the presence of low blood potassium levels. Fatalities due to overdosage of thioridazine are rare and those associated with therapeutic dosage and cross ...
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Synergism between Histamine, Antihistamines, and Hypnotic Drugs†
Journal of the American Pharmaceutical Association (Scientific ed.), 1952The synergism between antihistamines and the barbiturate Evipal was studied in mice. Similar synergism was found between histamine and barbiturates and between antihistamines and ether. The possible clinical usefulness of these findings is discussed. Thephorin, in mice, shows a synergistic effect with barbiturates or ether similar to that of Benadryl ...
J L, AMBRUS +4 more
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Molecular Pharmaceutics, 2018
Cancer therapies based on the combinations of different drugs and/or treatment modalities are emerging as important strategies for increasing efficacy and cure, decreasing unwanted toxicity, and overcoming drug resistance, provided that optimized drug ...
Elisa Gaio +6 more
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Cancer therapies based on the combinations of different drugs and/or treatment modalities are emerging as important strategies for increasing efficacy and cure, decreasing unwanted toxicity, and overcoming drug resistance, provided that optimized drug ...
Elisa Gaio +6 more
semanticscholar +1 more source
A Test for Synergism Between Two Drugs
Applied Statistics, 1976A likelihood ratio test is devised to detect the presence of synergism between two drugs which have similar actions. An example is given.
S. C. Darby, M. J. Ellis
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Synergism in Drug Treatment of Familial Hypercholesterolemia
1980The monogenic disorder familial hypercholesterolemia (FH) is associated with a high risk of premature coronary arteriosclerosis, largely attributable to a 2-3 fold increase in levels of low density lipoproteins (LDL) in serum. Heretofore, no regimen of drug therapy or surgical intervention has been reported which is capable of lowering levels of low ...
J. P. Kane +3 more
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Studies on the synergism of some hypotensive drugs with ethanol.
Polish journal of pharmacology and pharmacy, 1976Synergism of some hypotensive drugs with ethanol was studied for its influence on the central nervous system. A very strong central action of the drugs and ethanol administered simultaneously in subthreshold doses was observed. Intensity of synergism was calculated by comparing the results with the effective doses of each drug administered seperately.
Wilimowski, Marian +4 more
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Quantitative Aspects of Drug Antagonism and of Drug Synergism
1937It was shown in the last chapter that, in populations of animals, changes in sensitivity to drugs can be produced by a wide variety of causes, and that in some cases variations in sensitivity occur for which the causes are unknown. It seems justifiable to assume that if the condition of organisms is altered by the administration of one drug, then this ...
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Search for a Synergism with Different Drugs in the Field of Antiviral Chemotherapy
Chemotherapy, 2009Additional findings about the synergism between Rec. 15/0209 and Amantadine are reported. While it is clearly demonstrable in embryonated and de-embryonated chicken eggs by measuring both virus titer and virus RNA synthesis of CAM suspensions, the results are much less constant in the embryonated eggs by measuring HA in the allantoic fluids and over ...
P, Altucci +4 more
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Synergism of Three Antimicrobial Drugs
Nature, 1966COMBINED therapy with two or more antibacterial drugs may be useful in the treatment of an individual case, and in discouraging the development of resistance1. A formula was previously presented which could be used in evaluating the combined effect of two drugs2.
D, Kaplan, W, Koch
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Synergizing drug repurposing and target identification for neurodegenerative diseases
Despite dedicated research efforts, the absence of disease-curing remedies for neurodegenerative diseases (NDDs) continues to jeopardize human society and stands as a challenge. Drug repurposing is an attempt to find new functionality of existing drugs and take it as an opportunity to discourse the clinically unmet need to treat neurodegeneration ...Mehar, Sahu +6 more
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